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作者：Smith, Keith T.
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作者：Christou, Nina-Eleni; Apostolopoulou, Virginia; Melo, Diogo V. M.; Ruppert, Matthias; Fadini, Alisia; Henkel, Alessandra; Sprenger, Janina; Oberthuer, Dominik; Guenther, Sebastian; Pateras, Anastasios; Mashhour, Aida Rahmani; Yefanov, Oleksandr M.; Galchenkova, Marina; Reinke, Patrick Y. A.; Kremling, Viviane; Scheer, T. Emilie S.; Lange, Esther R.; Middendorf, Philipp; Schubert, Robin; De Zitter, Elke; Lumbao-Conradson, Koya; Herrmann, Jonathan; Rahighi, Simin; Kunavar, Ajda; Beale, Emma V.; Beale, John H.; Cirelli, Claudio; Johnson, Philip J. M.; Dworkowski, Florian; Ozerov, Dmitry; Bertrand, Quentin; Wranik, Maximilian; Bacellar, Camila; Bajt, Sasa; Wakatsuki, Soichi; Sellberg, Jonas A.; Huse, Nils; Turk, Dusan; Chapman, Henry N.; Lane, Thomas J.
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); European XFEL; University of Hamburg; Imperial College London; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; University of Ljubljana; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Royal Institute of Technology; Slovenian Academy of Sciences & Arts (SASA); Jozef Stefan Institute; University of Hamburg; Horiba Ltd.; University of Cambridge; University of Colorado System; University of Colorado Anschutz Medical Campus; Chapman University System; Chapman University; National Institute of Chemistry - Slovenia
摘要：Photolyase is an enzyme that uses light to catalyze DNA repair. To capture the reaction intermediates involved in the enzyme's catalytic cycle, we conducted a time-resolved crystallography experiment. We found that photolyase traps the excited state of the active cofactor, flavin adenine dinucleotide (FAD), in a highly bent geometry. This excited state performs electron transfer to damaged DNA, inducing repair. We show that the repair reaction, which involves the lysis of two covalent bonds, o...
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作者：Ash, Caroline
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作者：Voosen, Paul
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作者：Maestre-Reyna, Manuel; Wang, Po-Hsun; Nango, Eriko; Hosokawa, Yuhei; Saft, Martin; Furrer, Antonia; Yang, Cheng-Han; Putu, Eka Putra Gusti Ngurah; Wu, Wen-Jin; Emmerich, Hans-Joachim; Caramello, Nicolas; Franz-Badur, Sophie; Yang, Chao; Engilberge, Sylvain; Wranik, Maximilian; Glover, Hannah Louise; Weinert, Tobias; Wu, Hsiang-Yi; Lee, Cheng-Chung; Huang, Wei-Cheng; Huang, Kai-Fa; Chang, Yao-Kai; Liao, Jiahn-Haur; Weng, Jui-Hung; Gad, Wael; Chang, Chiung-Wen; Pang, Allan H.; Yang, Kai-Chun; Lin, Wei-Ting; Chang, Yu-Chen; Gashi, Dardan; Beale, Emma; Ozerov, Dmitry; Nass, Karol; Knopp, Gregor; Johnson, Philip J. M.; Cirelli, Claudio; Milne, Chris; Bacellar, Camila; Sugahara, Michihiro; Owada, Shigeki; Joti, Yasumasa; Yamashita, Ayumi; Tanaka, Rie; Tanaka, Tomoyuki; Luo, Fangjia; Tono, Kensuke; Zarzycka, Wiktoria; Mueller, Pavel; Alahmad, Maisa Alkheder; Bezold, Filipp; Fuchs, Valerie; Gnau, Petra; Kiontke, Stephan; Korf, Lukas; Reithofer, Viktoria; Rosner, Christian Joshua; Seiler, Elisa Marie; Watad, Mohamed; Werel, Laura; Spadaccini, Roberta; Yamamoto, Junpei; Iwata, So; Zhong, Dongping; Standfuss, Joerg; Royant, Antoine; Bessho, Yoshitaka; Essen, Lars-Oliver; Tsai, Ming-Daw
作者单位：Academia Sinica - Taiwan; National Taiwan University; RIKEN; Tohoku University; University of Osaka; Philipps University Marburg; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; European Synchrotron Radiation Facility (ESRF); University of Hamburg; University System of Ohio; Ohio State University; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Japan Synchrotron Radiation Research Institute; Kyoto University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; University of Sannio; University System of Ohio; Ohio State University; Shanghai Jiao Tong University; National Taiwan University; University of California System; University of California San Diego
摘要：Photolyases, a ubiquitous class of flavoproteins, use blue light to repair DNA photolesions. In this work, we determined the structural mechanism of the photolyase-catalyzed repair of a cyclobutane pyrimidine dimer (CPD) lesion using time-resolved serial femtosecond crystallography (TR-SFX). We obtained 18 snapshots that show time-dependent changes in four reaction loci. We used these results to create a movie that depicts the repair of CPD lesions in the picosecond-to-nanosecond range, follow...
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作者：Roman, Joe
作者单位：University of Vermont
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作者：Brainard, Jeffrey
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作者：[Anonymous]
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作者：Zheng, Shanyu; Du, Feihong; Zheng, Lirong; Han, Donglin; Li, Qiang; Shi, Junye; Chen, Jiangping; Shi, Xiaoming; Huang, Houbing; Luo, Yaorong; Yang, Yurong; O'Reilly, Padraic; Wei, Linlin; de Souza, Nicolas; Hong, Liang; Qian, Xiaoshi
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Beijing Institute of Technology; Beijing Institute of Technology; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Australian Nuclear Science & Technology Organisation; Shanghai Jiao Tong University
摘要：The electrocaloric effect demands the maximized degree of freedom (DOF) of polar domains and the lowest energy barrier to facilitate the transition of polarization. However, optimization of the DOF and energy barrier-including domain size, crystallinity, multiconformation coexistence, polar correlation, and other factors in bulk ferroelectrics-has reached a limit. We used organic crystal dimethylhexynediol (DMHD) as a three-dimensional sacrificial master to assemble polar conformations at the ...
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作者：He, Haozhe; Kramer, Ryan J.; Soden, Brian J.; Jeevanjee, Nadir
作者单位：University of Miami; University System of Maryland; University of Maryland Baltimore; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Oceanic Atmospheric Admin (NOAA) - USA; Princeton University; National Oceanic Atmospheric Admin (NOAA) - USA
摘要：When evaluating the effect of carbon dioxide (CO2) changes on Earth's climate, it is widely assumed that instantaneous radiative forcing from a doubling of a given CO2 concentration (IRF2xCO2) is constant and that variances in climate sensitivity arise from differences in radiative feedbacks or dependence of these feedbacks on the climatological base state. Here, we show that the IRF2xCO2 is not constant, but rather depends on the climatological base state, increasing by about 25% for every do...
