作者：Leitner, Helga
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
作者：Rana, Vipin S.; Kitsou, Chrysoula; Dutta, Shraboni; Ronzetti, Michael H.; Zhang, Min; Bernard, Quentin; Smith, Alexis A.; Tomas-Cortazar, Julen; Yang, Xiuli; Wu, Ming-Jie; Kepple, Oleksandra; Li, Weizhong; Dwyer, Jennifer E.; Matias, Jaqueline; Baljinnyam, Bolormaa; Oliver, Jonathan D.; Rajeevan, Nallakkandi; Pedra, Joao H. F.; Narasimhan, Sukanya; Wang, Yan; Munderloh, Ulrike; Fikrig, Erol; Simeonov, Anton; Anguita, Juan; Pal, Utpal
作者单位：University System of Maryland; University of Maryland College Park; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); Yale University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Minnesota System; University of Minnesota Twin Cities; Yale University; University System of Maryland; University of Maryland Baltimore; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); Howard Hughes Medical Institute; Basque Foundation for Science; University College Dublin
摘要：Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-g). Host-derived IFN-g facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregula...
作者：Jaleh, Babak; Eslamipanah, Mahtab
作者单位：Bu Ali Sina University
作者：van Huis, Arnold; Gasco, Laura
作者单位：Wageningen University & Research; University of Turin
