2023

最新文章

• Atmospheric goals for sustainable development AI翻译
  作者：Keywood, Melita; Paton-Walsh, Clare; Lawrence, Mark; George, Christian; Formenti, Paola; Schofield, Roybn; Cleugh, Helen; Borgford-Parnell, Nathan; Capon, Anthony
  作者单位：Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Wollongong; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Centre National de la Recherche Scientifique (CNRS); University of Melbourne; Australian National University; Monash University
• Total synthesis of lissodendoric acid A via stereospecific trapping of a strained cyclic allene AI翻译
  作者：Ippoliti, Francesca M.; Adamson, Nathan J.; Wonilowicz, Laura G.; Nasrallah, Daniel J.; Darzi, Evan R.; Donaldson, Joyann S.; Garg, Neil K.
  作者单位：University of California System; University of California Los Angeles; Pfizer; Pfizer USA
  摘要：Small rings that contain allenes are unconventional transient compounds that have been known since the 1960s. Despite being discovered around the same time as benzyne and offering a number of synthetically advantageous features, strained cyclic allenes have seen relatively little use in chemical synthesis. We report a concise total synthesis of the manzamine alkaloid lissodendoric acid A, which hinges on the development of a regioselective, diastereoselective, and stereospecific trapping of a ...
• Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis AI翻译
  作者：Rubsam, Henriette; Kronauer, Christina; Abel, Nikolaj B.; Ji, Hongtao; Lironi, Damiano; Hansen, Simon B.; Nadzieja, Marcin; Kolte, Marie, V; Abel, Dorte; de Jong, Noor; Madsen, Lene H.; Liu, Huijun; Stougaard, Jens; Radutoiu, Simona; Andersen, Kasper R.
  作者单位：Aarhus University; Huazhong Agricultural University
  摘要：Understanding the composition and activation of multicomponent receptor complexes is a challenge in biology. To address this, we developed a synthetic approach based on nanobodies to drive assembly and activation of cell surface receptors and apply the concept by manipulating receptors that govern plant symbiosis with nitrogen-fixing bacteria. We show that the Lotus japonicus Nod factor receptors NFR1 and NFR5 constitute the core receptor complex initiating the cortical root nodule organogenes...
• China's population starts to fall AI翻译
  作者：[Anonymous]
• In 2022, Earth set new records for warming AI翻译
  作者：Enserink, Martin; Brainard, Jeffrey
• Citizen scientists report global rapid reductions in the visibility of stars from 2011 to 2022 AI翻译
  作者：Kyba, Christopher C. M.; Altintas, Yigit Oner; Walker, Constance E.; Newhouse, Mark
  作者单位：Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; Ruhr University Bochum; European Organisation for the Exploitation of Meteorological Satellites
  摘要：The artificial glow of the night sky is a form of light pollution; its global change over time is not well known. Developments in lighting technology complicate any measurement because of changes in lighting practice and emission spectra. We investigated the change in global sky brightness from 2011 to 2022 using 51,351 citizen scientist observations of naked-eye stellar visibility. The number of visible stars decreased by an amount that can be explained by an increase in sky brightness of 7 t...
• Now in charge, House Republicans ramp up probes AI翻译
  作者：Mervis, Jeffrey; Cohen, Jon
• Reef sharks face extinction AI翻译
  作者：[Anonymous]
• CRISPR technology: A decade of genome editing is only the beginning AI翻译
  作者：Wang, Joy Y.; Doudna, Jennifer A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Francisco; The J David Gladstone Institutes
  摘要：The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome editing, coupled with advances in computing and imaging capabilities, has initiated a new era in which genetic diseases and individual disease susceptibilities are both predictable and actionable. Likewise, genes responsible for plant traits can be identified and altered quickly, transforming the pace of agricultural research and plant breeding. In this Review, we discuss the current state of CRISPR-mediated...
• A funding mosaic for loss and damage AI翻译
  作者：Warner, Koko; Weisberg, Michael
  作者单位：University of Pennsylvania; International Organization for Migration; University of Pennsylvania; University of Pennsylvania