Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

• 成果类型: Article
• 署名作者: Rana, Vipin S.; Kitsou, Chrysoula; Dutta, Shraboni; Ronzetti, Michael H.; Zhang, Min; Bernard, Quentin; Smith, Alexis A.; Tomas-Cortazar, Julen; Yang, Xiuli; Wu, Ming-Jie; Kepple, Oleksandra; Li, Weizhong; Dwyer, Jennifer E.; Matias, Jaqueline; Baljinnyam, Bolormaa; Oliver, Jonathan D.; Rajeevan, Nallakkandi; Pedra, Joao H. F.; Narasimhan, Sukanya; Wang, Yan; Munderloh, Ulrike; Fikrig, Erol; Simeonov, Anton; Anguita, Juan; Pal, Utpal
• 署名单位: University System of Maryland; University of Maryland College Park; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); Yale University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Minnesota System; University of Minnesota Twin Cities; Yale University; University System of Maryland; University of Maryland Baltimore; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); Howard Hughes Medical Institute; Basque Foundation for Science; University College Dublin
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9092
• DOI: 10.1126/science.abl3837
• 发表日期: 2023-01-12
• 页码: 154-+
• 关键词: borrelia-burgdorferi; virulence determinant; gene-expression; outer-membrane; identification; diversity; complexes; EVOLUTION; infection; pathways

摘要

Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-g). Host-derived IFN-g facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.