作者：Ward, Adam S.; Wade, Jeffrey; Kelleher, Christa; Schewe, Rebecca L.
作者单位：Oregon State University; Syracuse University; Lafayette College; Syracuse University
作者：Hardeman, Keisha
作者单位：University of Texas System; University of Texas Southwestern Medical Center
作者：Tan, Bryce W. Q.
作者单位：National University of Singapore
作者：Salloum-Asfar, Salam
作者单位：Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar Biomedical Research Institute (QBRI)
作者：Cohen, Jon
摘要：Ropes, drones, insects, and dust cloths could make monitoring faster, safer, and cheaper
作者：Peng, Qi; Xie, Yufeng; Kuai, Lu; Wang, Han; Qi, Jianxun; Gao, George F.; Shi, Yi
作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Tsinghua University; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Chinese Academy of Medical Sciences - Peking Union Medical College
摘要：The World Health Organization declared mpox (or monkeypox) a public health emergency of international concern in July 2022, and prophylactic and therapeutic measures are in urgent need. The monkeypox virus (MPXV) has its own DNA polymerase F8, together with the processive cofactors A22 and E4, constituting the polymerase holoenzyme for genome replication. Here, we determined the holoenzyme structure in complex with DNA using cryo-electron microscopy at the global resolution of similar to 2.8 a...
