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作者：Zeller, Elke; Timmermann, Axel; Yun, Kyung-Sook; Raia, Pasquale; Stein, Karl; Ruan, Jiaoyang
作者单位：Institute for Basic Science - Korea (IBS); Pusan National University; Pusan National University
摘要：To investigate the role of vegetation and ecosystem diversity on hominin adaptation and migration, we identify past human habitat preferences over time using a transient 3-million-year earth system-biome model simulation and an extensive hominin fossil and archaeological database. Our analysis shows that early African hominins predominantly lived in open environments such as grassland and dry shrubland. Migrating into Eurasia, hominins adapted to a broader range of biomes over time. By linking...
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作者：Yang, Ji-Min; Lin, Yu-Kun; Sheng, Tao; Hu, Liang; Cai, Xin-Pei; Yu, Jin-Quan
作者单位：Scripps Research Institute
摘要：Regiocontrol in traditional cycloaddition reactions between unsaturated carbon compounds is often challenging. The increasing focus in modern medicinal chemistry on benzocyclobutene (BCB) scaffolds indicates the need for alternative, more selective routes to diverse rigid carbocycles rich in C(sp(3)) character. Here, we report a palladium-catalyzed double C-H activation of two adjacent methylene units in carboxylic acids, enabled by bidentate amide-pyridone ligands, to achieve a regio-controll...
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作者：Anna-Thomas, Reshma; Connor, Liam; Dai, Shi; Feng, Yi; Burke-Spolaor, Sarah; Beniamini, Paz; Yang, Yuan -Pei; Zhang, Yong-Kun; Aggarwal, Kshitij; Law, Casey J.; Li, Di; Niu, Chenhui; Chatterjee, Shami; Cruces, Marilyn; Duan, Ran; Filipovic, Miroslav D.; Hobbs, George; Lynch, Ryan S.; Miao, Chenchen; Niu, Jiarui; Ocker, Stella K.; Tsai, Chao-Wei; Wang, Pei; Xue, Mengyao; Yao, Ju-Mei; Yu, Wenfei; Zhang, Bing; Zhang, Lei; Zhu, Shiqiang; Zhu, Weiwei
作者单位：West Virginia University; West Virginia University; California Institute of Technology; California Institute of Technology; Western Sydney University; Chinese Academy of Sciences; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Australia Telescope National Facility; Zhejiang Laboratory; Open University Israel; Open University Israel; Yunnan University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Kwazulu Natal; Cornell University; Cornell University; Max Planck Society; National Radio Astronomy Observatory (NRAO); Green Bank Observatory; Beijing Normal University; Chinese Academy of Sciences; Xinjiang Astronomy Observatory, CAS; Chinese Academy of Sciences; Shanghai Astronomical Observatory, CAS; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
摘要：Fast radio bursts (FRBs) are brief, intense flashes of radio waves from unidentified extragalactic sources. Polarized FRBs originate in highly magnetized environments. We report observations of the repeating FRB 20190520B spanning 17 months, which show that the FRB's Faraday rotation is highly variable and twice changes sign. The FRB also depolarizes below radio frequencies of about 1 to 3 gigahertz. We interpret these properties as being due to changes in the parallel component of the magneti...
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作者：Weaver, K. J.; Holt, R. A.; Henry, E.; Lyu, Y.; Pletcher, S. D.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Rutgers University System; Rutgers University New Brunswick
摘要：Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they modulate physiology are unknown. We find that hunger modulates aging in Drosophila. Limitation of branched -chain amino acids (BCAAs) or activation of hunger-promoting neurons induced a hunger state that extended life span despite increased feeding. Alteration of the neuronal histone acetylome was associated with BCAA limitation, and preventing these alterations abrogated the effect of BCAA limitation t...
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作者：Hubert, Alex
作者单位：University of Warwick
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作者：Liodakis, I.; Koljonen, K. I. I.; Blinov, D.; Lindfors, E.; Alexander, K. D.; Hovatta, T.; Berton, M.; Hajela, A.; Jormanainen, J.; Kouroumpatzakis, K.; Mandarakas, N.; Nilsson, K.
作者单位：University of Turku; Aalto University; Norwegian University of Science & Technology (NTNU); Foundation for Research & Technology - Hellas (FORTH); University of Crete; Northwestern University; University of Arizona; European Southern Observatory; University of Copenhagen; Niels Bohr Institute; University of Turku; Czech Academy of Sciences; Astronomical Institute of the Czech Academy of Sciences
摘要：A tidal disruption event (TDE) occurs when a supermassive black hole rips apart a passing star. Part of the stellar material falls toward the black hole, forming an accretion disk that in some cases launches a relativistic jet. We performed optical polarimetry observations of a TDE, AT 2020mot. We find a peak linear polarization degree of 25 +/- 4%, consistent with highly polarized synchrotron radiation, as is typically observed from relativistic jets. However, our radio observations, taken up...
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作者：Chong, Lina; Gao, Guoping; Wen, Jianguo; Li, Haixia; Xu, Haiping; Green, Zach; Sugar, Joshua D.; Kropf, A. Jeremy; Xu, Wenqian; Lin, Xiao-Min; Xu, Hui; Wang, Lin-Wang; Liu, Di-Jia
作者单位：United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago
摘要：Discovery of earth-abundant electrocatalysts to replace iridium for the oxygen evolution reaction (OER) in a proton exchange membrane water electrolyzer (PEMWE) represents a critical step in reducing the cost for green hydrogen production. We report a nanofibrous cobalt spinel catalyst codoped with lanthanum (La) and manganese (Mn) prepared from a zeolitic imidazolate framework embedded in electrospun polymer fiber. The catalyst demonstrated a low overpotential of 353 millivolts at 10 milliamp...
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作者：Klapper, Martin; Huebner, Alexander; Ibrahim, Anan; Wasmuth, Ina; Borry, Maxime; Haensch, Veit G.; Zhang, Shuaibing; Al-Jammal, Walid K.; Suma, Harikumar; Yates, James A. Fellows; Frangenberg, Jasmin; Velsko, Irina M.; Chowdhury, Somak; Herbst, Rosa; Bratovanov, Evgeni, V; Dahse, Hans-Martin; Horch, Therese; Hertweck, Christian; Morales, Manuel Ramon Gonzalez; Straus, Lawrence Guy; Vilotijevic, Ivan; Warinner, Christina; Stallforth, Pierre
作者单位：Leibniz Association; Hans Knoll Institute (HKI); Max Planck Society; Leibniz Association; Hans Knoll Institute (HKI); Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Universidad de Cantabria; Instituto Internacional de Investigaciones Prehistoricas de Cantabria (IIIPC); University of New Mexico; Universidad de Cantabria; Harvard University
摘要：Major advances over the past decade in the field of ancient DNA are providing access to past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this growing paleome remain largely elusive. We investigated the dental calculus of 12 Neanderthals and 52 anatomically modern humans ranging from 100,000 years ago to the present and reconstructed 459 bacterial metagenome-assembled genomes. We identified a biosynthetic gene cluster shared by seven Middle and Upper Paleo...
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作者：Harroud, Adil; Hafler, David A.
作者单位：McGill University; McGill University; McGill University; Yale University; Yale University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Autoimmune diseases display a high degree of comorbidity within individuals and families, suggesting shared risk factors. Over the past 15 years, genome-wide association studies have established the polygenic basis of these common conditions and revealed widespread sharing of genetic effects, indicative of a shared immunopathology. Despite ongoing challenges in determining the precise genes and molecular consequences of these risk variants, functional experiments and integration with multimoda...
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作者：Wadman, Meredith
