Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

• 成果类型: Article
• 署名作者: Klapper, Martin; Huebner, Alexander; Ibrahim, Anan; Wasmuth, Ina; Borry, Maxime; Haensch, Veit G.; Zhang, Shuaibing; Al-Jammal, Walid K.; Suma, Harikumar; Yates, James A. Fellows; Frangenberg, Jasmin; Velsko, Irina M.; Chowdhury, Somak; Herbst, Rosa; Bratovanov, Evgeni, V; Dahse, Hans-Martin; Horch, Therese; Hertweck, Christian; Morales, Manuel Ramon Gonzalez; Straus, Lawrence Guy; Vilotijevic, Ivan; Warinner, Christina; Stallforth, Pierre
• 署名单位: Leibniz Association; Hans Knoll Institute (HKI); Max Planck Society; Leibniz Association; Hans Knoll Institute (HKI); Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller University of Jena; Universidad de Cantabria; Instituto Internacional de Investigaciones Prehistoricas de Cantabria (IIIPC); University of New Mexico; Universidad de Cantabria; Harvard University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13918
• DOI: 10.1126/science.adf5300
• 发表日期: 2023-05-11
• 页码: 619-624
• 关键词: dental calculus; EVOLUTION

摘要

Major advances over the past decade in the field of ancient DNA are providing access to past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this growing paleome remain largely elusive. We investigated the dental calculus of 12 Neanderthals and 52 anatomically modern humans ranging from 100,000 years ago to the present and reconstructed 459 bacterial metagenome-assembled genomes. We identified a biosynthetic gene cluster shared by seven Middle and Upper Paleolithic individuals that allows for the heterologous production of a class of previously unknown metabolites that we name paleofurans. This paleobiotechnological approach demonstrates that viable biosynthetic machinery can be produced from the preserved genetic material of ancient organisms, allowing access to natural products from the Pleistocene and providing a promising area for natural product exploration.