6690期

最新文章

• Domestic US postdocs drop AI翻译
  作者：Brainard, Jeffrey
• Black hole pic hints at Milky Way jet AI翻译
  作者：Brainard, Jeffrey
• Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis AI翻译
  作者：Sahu, Umakant; Villa, Elodie; Reczek, Colleen R.; Zhao, Zibo; O'Hara, Brendan P.; Torno, Michael D.; Mishra, Rohan; Shannon, William D.; Asara, John M.; Gao, Peng; Shilatifard, Ali; Chandel, Navdeep S.; Ben-Sahra, Issam
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University; Feinberg School of Medicine; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Northwestern University; Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago
  摘要：Cellular purines, particularly adenosine 5 '-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, but not purines, maintain pyruvate oxidation and the tricarboxylic citric acid (TCA) cycle by regulating pyruvate dehydrogenase (PDH) activity. PDH activity requires sufficient substrates and cofactors, including thiamine pyrophosphate (TPP). Depletion of cellular pyrimidines decreased TPP sy...
• A hyperelastic hydrogel with an ultralarge reversible biaxial strain AI翻译
  作者：Chen, Lili; Jin, Zhekai; Feng, Wenwen; Sun, Lin; Xu, Hao; Wang, Chao
  作者单位：Tsinghua University
  摘要：Hyperelastic materials exhibit a nonlinear elastic response to large strains, whereas hydrogels typically possess a low elastic range due to the nonuniform cross-linking and limited chain segments among cross-links. We developed a hyperelastic hydrogel that possesses a broader elastic range by introducing a reversible pearl-necklace structure, in which beads are connected by strings. The subnanometric beads can efficiently unfold and refold under cyclic mechanical strains; thus, the hydrogel c...
• Shaken up by a shaker AI翻译
  作者：Eberhardt, Emily L.
  作者单位：University of Michigan System; University of Michigan
• China's plan to combat antimicrobial resistance AI翻译
  作者：Li, Xinyang; Wu, Yuye; Jiang, Tian; Chen, Bin; Feng, Rui; Zhang, Jun; Xie, Xinyou; Ruan, Zhi
  作者单位：Zhejiang University; Wenzhou Medical University; Zhejiang University; Zhejiang University
• Mandating indoor air quality for public buildings AI翻译
  作者：Morawska, Lidia; Allen, Joseph; Bahnfleth, William; Bennett, Belinda; Bluyssen, Philomena M.; Boerstra, Atze; Buonanno, Giorgio; Cao, Junji; Dancer, Stephanie J.; Floto, Andres; Franchimon, Francesco; Greenhalgh, Trish; Haworth, Charles; Hogeling, Jaap; Isaxon, Christina; Jimenez, Jose L.; Kennedy, Amanda; Kumar, Prashant; Kurnitski, Jarek; Li, Yuguo; Loomans, Marcel; Marks, Guy; Marr, Linsey C.; Mazzarella, Livio; Melikov, Arsen Krikor; Miller, Shelly L.; Milton, Donald K.; Monty, Jason; Nielsen, Peter V.; Noakes, Catherine; Peccia, Jordan; Prather, Kimberly A.; Querol, Xavier; Salthammer, Tunga; Sekhar, Chandra; Seppaenen, Olli; Tanabe, Shin-ichi; Tang, Julian W.; Tellier, Raymond; Tham, Kwok Wai; Wargocki, Pawel; Wierzbicka, Aneta; Yao, Maosheng
  作者单位：University of Queensland; University of Surrey; Harvard University; Harvard T.H. Chan School of Public Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Queensland University of Technology (QUT); Delft University of Technology; University of Cassino; Chinese Academy of Sciences; Edinburgh Napier University; University of Cambridge; University of Oxford; Papworth Hospital; University of Cambridge; Lund University; University of Colorado System; University of Colorado Boulder; Tallinn University of Technology; University of Hong Kong; Eindhoven University of Technology; University of New South Wales Sydney; Virginia Polytechnic Institute & State University; Polytechnic University of Milan; Technical University of Denmark; University of Colorado System; University of Colorado Boulder; University System of Maryland; University of Maryland Baltimore; University of Melbourne; Aalborg University; University of Leeds; Yale University; University of California System; University of California San Diego; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de Diagnostico Ambiental y Estudios del Agua (IDAEA); National University of Singapore; Aalto University; Waseda University; University of Leicester; McGill University; Lund University; Peking University
  摘要：If some countries lead by example, standards may increasingly become normalized People living in urban and industrialized societies, which are expanding globally, spend more than 90% of their time in the indoor environment, breathing indoor air (IA). Despite decades of research and advocacy, most countries do not have legislated indoor air quality (IAQ) performance standards for public spaces that address concentration levels of IA pollutants ( 1 ). Few building codes address operation, mainte...
• A more biofriendly piezoelectric material AI翻译
  作者：Wang, Linping; Li, Run-Wei
  作者单位：Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS; Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Devices implanted in the human body for sensing conditions and delivering treatments must be biosafe, biocompatible, and biodegradable. These requirements make piezoelectric materials attractive for their design because they convert mechanical force into electricity and vice versa (1). However, traditional piezoelectrics such as lead zirconate titanate are permanent, rather than transient, in nature (2, 3). Although biodegradable piezoelectrics-such as those including amino acids, collagen, an...
• West Virginia OKs intelligent design in schools AI翻译
  作者：Mervis, Jeffrey
  摘要：Governor signs bill allowing teachers to discuss antievolutionary theories
• Oxygen imaging of hypoxic pockets in the mouse cerebral cortex AI翻译
  作者：Beinlich, Felix R. M.; Asiminas, Antonios; Untiet, Verena; Bojarowska, Zuzanna; Pla, Virginia; Sigurdsson, Bjoern; Timmel, Vincenzo; Gehrig, Lukas; Graber, Michael H.; Hirase, Hajime; Nedergaard, Maiken
  作者单位：University of Copenhagen; University of Rochester
  摘要：Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (Po-2) dynamics under physiological conditions. Here we introduce Green enhanced Nano-lantern (GeNL), a genetically encoded bioluminescent oxygen indicator for Po-2 imaging. In awake behaving mice, we uncover the existence of spontaneous, s...