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作者：Service, Robert F.
摘要：Automated labs spread across the globe create, test, and assemble materials-no humans required
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作者：Strieth-Kalthoff, Felix; Hao, Han; Rathore, Vandana; Derasp, Joshua; Gaudin, Theophile; Angello, Nicholas H.; Seifrid, Martin; Trushina, Ekaterina; Guy, Mason; Liu, Junliang; Tang, Xun; Mamada, Masashi; Wang, Wesley; Tsagaantsooj, Tuul; Lavigne, Cyrille; Pollice, Robert; Wu, Tony C.; Hotta, Kazuhiro; Bodo, Leticia; Li, Shangyu; Haddadnia, Mohammad; Wolos, Agnieszka; Roszak, Rafal; Ser, Cher Tian; Bozal-Ginesta, Carlota; Hickman, Riley J.; Vestfrid, Jenya; Aguilar-Granda, Andres; Klimareva, Elena L.; Sigerson, Ralph C.; Hou, Wenduan; Gahler, Daniel; Lach, Slawomir; Warzybok, Adrian; Borodin, Oleg; Rohrbach, Simon; Sanchez-Lengeling, Benjamin; Adachi, Chihaya; Grzybowski, Bartosz A.; Cronin, Leroy; Hein, Jason E.; Burke, Martin D.; Aspuru-Guzik, Alan
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of British Columbia; University of Illinois System; University of Illinois Urbana-Champaign; North Carolina State University; University of Glasgow; Kyushu University; Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Vector Institute for Artificial Intelligence; Polish Academy of Sciences; Institute of Organic Chemistry of the Polish Academy of Sciences; Institut de Recerca en Energia de Catalunya (IREC); Jagiellonian University; Alphabet Inc.; Google Incorporated; Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST); University of Bergen; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR)
摘要：Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based strategy that enabled delocalized and asynchronous design-make-test-analyze cycles. We showcased this approach through the exploration of molecular gain materials for organic solid-state lasers as a frontier application in molecular optoelectronics. ...
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作者：Alford, C. Fred
作者单位：University System of Maryland; University of Maryland College Park
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作者：Sanders, Rogier W.; Moore, John P.
作者单位：University of Amsterdam; Cornell University; Weill Cornell Medicine
摘要：Four new studies inform on the multistep path to generate broadly active HIV-1 antibodies
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作者：Warren, Matthew
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作者：Zhang, Tao; Zhang, Zi-Yu; Kang, Guowei; Sheng, Tao; Yan, Jie-Lun; Yang, Yuan-Bin; Ouyang, Yuxin; Yu, Jin-Quan
作者单位：Scripps Research Institute
摘要：Stereoselective construction of gamma- and delta-stereocenters in carbonyl compounds is a pivotal objective in asymmetric synthesis. Here, we report chiral bifunctional oxazoline-pyridone ligands that enable enantioselective palladium-catalyzed remote gamma-C-H (hetero)arylations of free cycloalkane carboxylic acids, which are essential carbocyclic building blocks in organic synthesis. The reaction establishes gamma-tertiary and alpha-quaternary stereocenters simultaneously in up to >99% enant...
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作者：Wadman, Meredith
摘要：Heroic network forges ahead as gang violence dominates life and landscape
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作者：Li, Yueyue; Hou, Yanjie; Sun, Qi; Zeng, Huan; Meng, Fanyi; Tian, Xiang; He, Qun; Shao, Feng; Ding, Jingjin
作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National Institute of Biological Sciences, Beijing; China Agricultural University; National Institute of Biological Sciences, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Changping Laboratory; Tsinghua University
摘要：Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory domain. In this work, we report two types of cleavage-independent GSDM activation. First, TrichoGSDM, a pore-forming domain-only protein from the basal metazoan Trichoplax adhaerens, is a disulfides-linked autoinhibited dimer activated by reduction of the disulfides. The cryo-electron microscopy (cryo-EM) structure illustrates...
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作者：Grant, Phillip S.; Vavrik, Milos; Porte, Vincent; Meyrelles, Ricardo; Maulide, Nuno
作者单位：University of Vienna; University of Vienna
摘要：Generally, the acidity of carbon-hydrogen bonds is most sensitive to functionality just one or two bonds away. Here, we present an approach to the formation of carbon-carbon sigma bonds by remote proton elimination, a distinct mode of carbon-hydrogen activation enabled by distal acidification through five carbon-carbon bonds. Application of remote proton elimination to cyclodecyl cations unveiled an appealing method for the synthesis of decalins. The transformation is regioconvergent, proceeds...
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作者：Boon, Nicolaas J.; Oliveira, Rafaela A.; Koerner, Pierre-Rene; Kochavi, Adva; Mertens, Sander; Malka, Yuval; Voogd, Rhianne; van der Horst, Suzanne E. M.; Huismans, Maarten A.; Smabers, Lidwien P.; Draper, Jonne M.; Wessels, Lodewyk F. A.; Haahr, Peter; Roodhart, Jeanine M. L.; Schumacher, Ton N. M.; Snippert, Hugo J.; Agami, Reuven; Brummelkamp, Thijn R.
作者单位：Netherlands Cancer Institute; Netherlands Cancer Institute; Utrecht University; Utrecht University Medical Center; Netherlands Cancer Institute; Utrecht University; Utrecht University Medical Center; Netherlands Cancer Institute; University of Copenhagen
摘要：In response to excessive DNA damage, human cells can activate p53 to induce apoptosis. Cells lacking p53 can still undergo apoptosis upon DNA damage, yet the responsible pathways are unknown. We observed that p53-independent apoptosis in response to DNA damage coincided with translation inhibition, which was characterized by ribosome stalling on rare leucine-encoding UUA codons and globally curtailed translation initiation. A genetic screen identified the transfer RNAse SLFN11 and the kinase G...
