6697期

最新文章

• Tool use promotes dental health AI翻译
  作者：Klump, Barbara C.
  作者单位：University of Vienna; University of Vienna; Max Planck Society
  摘要：Using tools increases foraging success in sea otters and protects their teeth from damage
• The complexity of physician power AI翻译
  作者：Nimmon, Laura
  作者单位：University of British Columbia; University of British Columbia
  摘要：Inequitable variation in physician effort and resource use is revealed
• Cancer risk in Black women AI翻译
  作者：Warren, Matthew
• mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies AI翻译
  作者：Xie, Zhenfei; Lin, Ying-Cing; Steichen, Jon M.; Ozorowski, Gabriel; Kratochvil, Sven; Ray, Rashmi; Torres, Jonathan L.; Liguori, Alessia; Kalyuzhniy, Oleksandr; Wang, Xuesong; Warner, John E.; Weldon, Stephanie R.; Dale, Gordon A.; Kirsch, Kathrin H.; Nair, Usha; Baboo, Sabyasachi; Georgeson, Erik; Adachi, Yumiko; Kubitz, Michael; Jackson, Abigail M.; Richey, Sara T.; Volk, Reid M.; Lee, Jeong Hyun; Diedrich, Jolene K.; Prum, Thavaleak; Falcone, Samantha; Himansu, Sunny; Carfi, Andrea; Yates III, John R.; Paulson, James C.; Sok, Devin; Ward, Andrew B.; Schief, William R.; Batista, Facundo D.
  作者单位：Scripps Research Institute; International AIDS Vaccine Initiative; Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Massachusetts Institute of Technology (MIT)
  摘要：INTRODUCTION Broadly neutralizing antibodies (bnAbs) isolated from HIV-1-infected patients demonstrate that the humoral immune system can develop effective antibody responses to HIV, even if those antibodies are rare and the result of a somewhat winding journey. Germline-targeting (GT) vaccination seeks to induce bnAbs through sequential immunization. To overcome the relatively low affinity of many germline precursors to bnAbs to the HIV-1 envelope protein (Env), precursors to bnAbs are identi...
• Building on NIH's data sharing policy AI翻译
  作者：Contaxis, Nicole; Badger, Kelsey; Bohman, Lena; Gonzales, Sara; Kim, Seonyoung; Koshoffer, Amy; Milliken, Genevieve; Newman, Jess; Otsuji, Reid; Renirie, Rebecca; Smith, Katy; Urmi, Ummea; Yarnell, Amy; Ye, Hao; Yee, Michelle
  作者单位：New York University; University System of Ohio; Ohio State University; Hofstra University; Northwell Health; Northwell Health; Northwestern University; Feinberg School of Medicine; Washington University (WUSTL); Saint Louis University; University System of Ohio; University of Cincinnati; University of Tennessee System; University of Tennessee Health Science Center; University of California System; University of California San Diego; Central Michigan University; Saint Louis University; University System of Maryland; University of Maryland Baltimore; University of Pennsylvania
• Why are elite athletes prone to heart arrhythmias? AI翻译
  作者：Couzin-Frankel, Jennifer
  摘要：Studying cardiac effects of extreme exercise could yield clues to atrial fibrillation
• Repair of CRISPR-guided RNA breaks enables site-specific RNA excision in human cells AI翻译
  作者：Nemudraia, Anna; Nemudryi, Artem; Wiedenheft, Blake
  作者单位：Montana State University System; Montana State University Bozeman
  摘要：Genome editing with CRISPR RNA-guided endonucleases generates DNA breaks that are resolved by cellular DNA repair machinery. However, analogous methods to manipulate RNA remain unavailable. We show that site-specific RNA breaks generated with type-III CRISPR complexes are repaired in human cells and that this repair can be used for programmable deletions in human transcripts to restore gene function. Collectively, this work establishes a technology for precise RNA manipulation with potential t...
• How power shapes behavior: Evidence from physicians AI翻译
  作者：Schwab, Stephen D.; Singh, Manasvini
  作者单位：University of Texas System; University of Texas at San Antonio; Carnegie Mellon University
  摘要：Power-the asymmetric control of valued resources-affects most human interactions. Although power is challenging to study with real-world data, a distinctive dataset allowed us to do so within the critical context of doctor-patient relationships. Using 1.5 million quasi-random assignments in US military emergency departments, we examined how power differentials between doctor and patient (measured by using differences in military ranks) affect physician behavior. Our findings indicate that powe...
• Plan to alter access to health data draws ire AI翻译
  作者：Wadman, Meredith
  摘要：Universities could no longer store Medicare and Medicaid data, and costs would rise
• NSF halts South Pole probe of cosmic inflation AI翻译
  作者：Cho, Adrian
  摘要：Aging infrastructure there cannot support suite of new telescopes, agency says