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作者：Mamassian, Pascal
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS)
摘要：Late development of color vision improves object recognition
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作者：Zeng, Biao; Bendl, Jaroslav; Deng, Chengyu; Lee, Donghoon; Misir, Ruth; Reach, Sarah M.; Kleopoulos, Steven P.; Auluck, Pavan; Marenco, Stefano; Lewis, David A.; Haroutunian, Vahram; Ahituv, Nadav; Fullard, John F.; Hoffman, Gabriel E.; Roussos, Panos
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount Sinai; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center
摘要：Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons from 616 human postmortem brains and identified 34,539 open chromatin regions with chromatin accessibility quantitative trait loci (caQTLs). Only 10.4% of caQTLs are shared between neurons and non-neurons, which supports cell type-specific genetic regulation of the brain regulome. Incorpo...
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作者：Rafiq, Kasim; Jordan, Neil R.; McNutt, J. Weldon; Neelo, John; Attias, Nina; Boersma, Dee; Palmer, Meredith S.; Ruesink, Jennifer; Abrahms, Briana
作者单位：University of Washington; University of Washington Seattle; University of New South Wales Sydney; Taronga Conservation Society Australia; University of Washington; University of Washington Seattle
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作者：Leslie, Mitch
摘要：Faulty messaging between organs could make us old
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作者：Zhang, Jianping; Jiang, Leping; Yu, Lupeng; Huan, Xiujia; Zhou, Liping; Wang, Changsheng; Jin, Jianhui; Zuo, Xinxin; Wu, Naiqin; Zhao, Zhijun; Sun, Hanlong; Yu, Zhaoyuan; Zhang, Guoping; Zhu, Jiangping; Wu, Zhenlei; Dong, Yajie; Fan, Baoshuo; Shen, Caiming; Lu, Houyuan
作者单位：Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; Linyi University; Peking University; Fujian Normal University; Shandong University; Hebei Normal University; Yunnan Normal University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Rice (Oryza sativa) serves as a staple food for more than one-third of the global population. However, its journey from a wild gathered food to domestication remains enigmatic, sparking ongoing debates in the biological and anthropological fields. Here, we present evidence of rice phytoliths sampled from two archaeological sites in China, Shangshan and Hehuashan, near the lower reaches of the Yangtze River. We demonstrate the growth of wild rice at least 100,000 years before present, its initi...
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作者：Daskalakis, Nikolaos P.; Iatrou, Artemis; Chatzinakos, Chris; Jajoo, Aarti; Snijders, Clara; Wylie, Dennis; Dipietro, Christopher P.; Tsatsani, Ioulia; Chen, Chia-Yen; Pernia, Cameron D.; Soliva-Estruch, Marina; Arasappan, Dhivya; Bharadwaj, Rahul A.; Collado-Torres, Leonardo; Wuchty, Stefan; Alvarez, Victor E.; Dammer, Eric B.; Deep-Soboslay, Amy; Duong, Duc M.; Eagles, Nick; Huber, Bertrand R.; Huuki, Louise; Holstein, Vincent L.; Logue, Mark W.; Lugenbuhl, Justina F.; Maihofer, Adam X.; Miller, Mark W.; Nievergelt, Caroline M.; Pertea, Geo; Ross, Deanna; Sendi, Mohammad S. E.; Sun, Benjamin B.; Tao, Ran; Tooke, James; Wolf, Erika J.; Zeier, Zane; Berretta, Sabina; Champagne, Frances A.; Hyde, Thomas; Seyfried, Nicholas T.; Shin, Joo Heon; Weinberger, Daniel R.; Nemeroff, Charles B.; Kleinman, Joel E.; Ressler, Kerry J.
作者单位：Harvard University; Harvard University Medical Affiliates; McLean Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; State University of New York (SUNY) System; SUNY Downstate Health Sciences University; University of Texas System; University of Texas Austin; Maastricht University; Biogen; Johns Hopkins University; Johns Hopkins Medicine; University of Miami; University of Miami; Boston University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Emory University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Boston University; Boston University; Boston University; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of Texas System; University of Texas Austin; University of Miami; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of Texas System; University of Texas Austin
摘要：The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) included the central nucleus of the amygdala, hippocampal dentate gyrus, and medial prefrontal cortex (mPFC). Genes and exons within the mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal and synaptic regulation, and stress hormones. Multiomi...
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作者：Huang, Weiyuan; Liu, Tongchao; Yu, Lei; Wang, Jing; Zhou, Tao; Liu, Junxiang; Li, Tianyi; Amine, Rachid; Xiao, Xianghui; Ge, Mingyuan; Ma, Lu; Ehrlich, Steven N.; Holt, Martin V.; Wen, Jianguo; Amine, Khalil
作者单位：United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
摘要：Transitioning from polycrystalline to single-crystalline nickel-rich cathodes has garnered considerable attention in both academia and industry, driven by advantages of high tap density and enhanced mechanical properties. However, cathodes with high nickel content (>70%) suffer from substantial capacity degradation, which poses a challenge to their commercial viability. Leveraging multiscale spatial resolution diffraction and imaging techniques, we observe that lattice rotations occur universa...
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作者：Nusinovich, Yevgeniya
摘要：A cell-by-cell look at neuropsychiatric diseases
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作者：Fan, Penglai; Lawes, Michael J.; Liu, Ruoshuang; Zhou, Qihai
作者单位：Guangxi Normal University; Guangxi Normal University; University of Kwazulu Natal; University of Malaysia Sarawak
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作者：Emani, Prashant S.; Liu, Jason J.; Clarke, Declan; Jensen, Matthew; Warrell, Jonathan; Gupta, Chirag; Meng, Ran; Lee, Che Yu; Xu, Siwei; Dursun, Cagatay; Lou, Shaoke; Chen, Yuhang; Chu, Zhiyuan; Galeev, Timur; Hwang, Ahyeon; Li, Yunyang; Ni, Pengyu; Zhou, Xiao; Bakken, Trygve E.; Bendl, Jaroslav; Bicks, Lucy; Chatterjee, Tanima; Cheng, Lijun; Cheng, Yuyan; Dai, Yi; Duan, Ziheng; Flaherty, Mary; Fullard, John F.; Gancz, Michael; Garrido-Martin, Diego; Gaynor-Gillett, Sophia; Grundman, Jennifer; Hawken, Natalie; Henry, Ella; Hoffman, Gabriel E.; Huang, Ao; Jiang, Yunzhe; Jin, Ting; Jorstad, Nikolas L.; Kawaguchi, Riki; Khullar, Saniya; Liu, Jianyin; Liu, Junhao; Liu, Shuang; Ma, Shaojie; Margolis, Michael; Mazariegos, Samantha; Moore, Jill; Moran, Jennifer R.; Nguyen, Eric; Phalke, Nishigandha; Pjanic, Milos; Pratt, Henry; Quintero, Diana; Rajagopalan, Ananya S.; Riesenmy, Tiernon R.; Shedd, Nicole; Shi, Manman; Spector, Megan; Terwilliger, Rosemarie; Travaglini, Kyle J.; Wamsley, Brie; Wang, Gaoyuan; Xia, Yan; Xiao, Shaohua; Yang, Andrew C.; Zheng, Suchen; Gandal, Michael J.; Lee, Donghoon; Lein, Ed S.; Roussos, Panos; Sestan, Nenad; Weng, Zhiping; White, Kevin P.; Won, Hyejung; Girgenti, Matthew J.; Zhang, Jing; Wang, Daifeng; Geschwind, Daniel; Gerstein, Mark
作者单位：Yale University; Yale University; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Irvine; University of California System; University of California Irvine; Yale University; Allen Institute for Brain Science; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Barcelona; Cornell University; Weill Cornell Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; University of California System; University of California Los Angeles; Yale University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Yale University; Yale University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; National University of Singapore; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Yale University
摘要：Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics datasets into a resource comprising >2.8 million nuclei from the prefrontal cortex across 388 individuals. For 28 cell types, we assessed population-level variation in expression and chromatin across gene families and drug targets. We identified >5...
