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作者：Wamsley, Brie; Bicks, Lucy; Cheng, Yuyan; Kawaguchi, Riki; Quintero, Diana; Margolis, Michael; Grundman, Jennifer; Liu, Jianyin; Xiao, Shaohua; Hawken, Natalie; Mazariegos, Samantha; Geschwind, Daniel H.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood. We performed deep single-nucleus RNA sequencing (snRNA-seq) to examine cell composition and transcriptomics, identifying dysregulation of cell type-specific gene regulatory networks (GRNs) in autism spectrum disorder (ASD), which we corroborated using sin...
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作者：Zhu, Shihan; Shen, Zeyu; Wu, Xiandeng; Han, Wenyan; Jia, Bowen; Lu, Wei; Zhang, Mingjie
作者单位：Hong Kong University of Science & Technology; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Southern University of Science & Technology
摘要：Excitatory and inhibitory synapses do not overlap even when formed on one submicron-sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or densities (e/iPSDs) are segregated is not understood. Broadly, why membraneless organelles are naturally segregated in cellular subcompartments is unclear. Using biochemical reconstitutions in vitro and in cells, we demonstrate that ePSDs and iPSDs spontaneously segregate into distinct condensed molecular assemblies through p...
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作者：Duan, Tianwei; You, Shuai; Chen, Min; Yu, Wenjian; Li, Yanyan; Guo, Peijun; Berry, Joseph J.; Luther, Joseph M.; Zhu, Kai; Zhou, Yuanyuan
作者单位：Hong Kong Baptist University; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; Yale University; Yale University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Hong Kong University of Science & Technology
摘要：Mechanical failure and chemical degradation of device heterointerfaces can strongly influence the long-term stability of perovskite solar cells (PSCs) under thermal cycling and damp heat conditions. We report chirality-mediated interfaces based on R-/S-methylbenzyl-ammonium between the perovskite absorber and electron-transport layer to create an elastic yet strong heterointerface with increased mechanical reliability. This interface harnesses enantiomer-controlled entropy to enhance tolerance...
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作者：Zaluar, Marina T.; Vale, Mariana M.; Alves, Maria Alice S.
作者单位：Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de Janeiro; Universidade do Estado do Rio de Janeiro
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作者：Liao, Diana A.; Brecht, Katharina F.; Veit, Lena; Nieder, Andreas
作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen
摘要：Producing a specific number of vocalizations with purpose requires a sophisticated combination of numerical abilities and vocal control. Whether this capacity exists in animals other than humans is yet unknown. We show that crows can flexibly produce variable numbers of one to four vocalizations in response to arbitrary cues associated with numerical values. The acoustic features of the first vocalization of a sequence were predictive of the total number of vocalizations, indicating a planning...
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作者：Deng, Chengyu; Whalen, Sean; Steyert, Marilyn; Ziffra, Ryan; Przytycki, Pawel F.; Inoue, Fumitaka; Pereira, Daniela A.; Capauto, Davide; Norton, Scott; Vaccarino, Flora M.; Pollen, Alex A.; Nowakowski, Tomasz J.; Ahituv, Nadav; Pollard, Katherine S.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco; Kyoto University; Universidade Federal de Minas Gerais; Yale University; Yale University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 open chromatin regions, including thousands of sequences with cell type-specific accessibility and variants associated with brain gene regulation. In primary cells, we identified 46,802 active enhancer sequences and 1...
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作者：O'Callaghan, Jonathan
摘要：Apparent overabundance means theories of how galaxies took shape in the early universe may need adjusting
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作者：Patowary, Ashok; Zhang, Pan; Jops, Connor; Vuong, Celine K.; Ge, Xinzhou; Hou, Kangcheng; Kim, Minsoo; Gong, Naihua; Margolis, Michael; Vo, Daniel; Wang, Xusheng; Liu, Chunyu; Pasaniuc, Bogdan; Li, Jingyi Jessica; Gandal, Michael J.; de la Torre-Ubieta, Luis
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; State University of New York (SUNY) System; SUNY Upstate Medical University; Central South University; Central South University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
摘要：RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type-specific splicing and transcript-isoform diversity during human brain development has not been systematically investigated. In this work, we leveraged single-molecule long-read sequencing to deeply profile the full-length transcriptome of the germinal zone and cortical plate regions of the developing human neocortex at tissue and single-cell resolution. We identified 214...
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作者：Brainard, Jeffrey
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作者：Kaiser, Jocelyn
摘要：EcoHealth Alliance mishandled grant that helped fund virus studies in China, officials say
