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作者：Ruzicka, W. Brad; Mohammadi, Shahin; Fullard, John F.; Davila-Velderrain, Jose; Subburaju, Sivan; Tso, Daniel Reed; Hourihan, Makayla; Jiang, Shan; Lee, Hao-Chih; Bendl, Jaroslav; Voloudakis, Georgios; Haroutunian, Vahram; Hoffman, Gabriel E.; Roussos, Panos; Kellis, Manolis
作者单位：Harvard University; Harvard University Medical Affiliates; McLean Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Human Technopole; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center
摘要：The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal cortex across 140 individuals in two independent cohorts. Excitatory neurons were the most affected cell group, with transcriptional changes converging on neurodevelopment and synapse-related molecular pathways. Transcriptional alterations incl...
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作者：Vogelsang, Marin; Vogelsang, Lukas; Gupta, Priti; Gandhi, Tapan K.; Shah, Pragya; Swami, Piyush; Gilad-Gutnick, Sharon; Ben-Ami, Shlomit; Diamond, Sidney; Ganesh, Suma; Sinha, Pawan
作者单位：Massachusetts Institute of Technology (MIT); University Osnabruck; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi; Dayalbagh Educational Institute (DEI); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi; Technical University of Denmark; University of Copenhagen
摘要：Human visual recognition is remarkably robust to chromatic changes. In this work, we provide a potential account of the roots of this resilience based on observations with 10 congenitally blind children who gained sight late in life. Several months or years following their sight-restoring surgeries, the removal of color cues markedly reduced their recognition performance, whereas age-matched normally sighted children showed no such decrement. This finding may be explained by the greater-than-n...
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作者：Baker, Rachel E.
作者单位：Brown University
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作者：Lubchenco, Jane; Galvin, Kathleen A.
作者单位：Oregon State University; Colorado State University System; Colorado State University Fort Collins
摘要：Pioneering Antarctic ecologist and ambassador for soil health
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作者：Ku, Angela F.; Sharma, Kiran L.; Ta, Hai Minh; Sutton, Courtney M.; Bohren, Kurt M.; Wang, Yong; Chamakuri, Srinivas; Chen, Ruihong; Hakenjos, John M.; Jimmidi, Ravikumar; Kent, Katarzyna; Li, Feng; Li, Jian-Yuan; Ma, Lang; Madasu, Chandrashekhar; Palaniappan, Murugesan; Palmer, Stephen S.; Qin, Xuan; Robers, Matthew B.; Sankaran, Banumathi; Tan, Zhi; Vasquez, Yasmin M.; Wang, Jian; Wilkinson, Jennifer; Yu, Zhifeng; Ye, Qiuji; Young, Damian W.; Teng, Mingxing; Kim, Choel; Matzuk, Martin M.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Promega Corporation; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Men or mice with homozygous serine/threonine kinase 33 (STK33) mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33 for male contraception with STK33-specific inhibitors, we screened our multibillion-compound collection of DNA-encoded chemical libraries, uncovered potent STK33-specific inhibitors, determined the STK33 kinase domain structure bound with a truncated hit CDD-2211, and generated an optimized hit CDD-2807 that demonstrates nanomolar c...
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作者：Qie, Boyu; Wang, Ziyi; Jiang, Jingwei; Zhang, Zisheng; Jacobse, Peter H.; Lu, Jiaming; Li, Xinheng; Liu, Fujia; Alexandrova, Anastassia N.; Louie, Steven G.; Crommie, Michael F.; Fischer, Felix R.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Berkeley
摘要：The covalent interaction of N-heterocyclic carbenes (NHCs) with transition metal atoms gives rise to distinctive frontier molecular orbitals (FMOs). These emergent electronic states have spurred the widespread adoption of NHC ligands in chemical catalysis and functional materials. Although formation of carbene-metal complexes in self-assembled monolayers on surfaces has been explored, design and electronic structure characterization of extended low-dimensional NHC-metal lattices remains elusiv...
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作者：Novarino, Gaia; Bock, Christoph
作者单位：Institute of Science & Technology - Austria; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Medical University of Vienna
摘要：DNA sequences are connected to genes and functions in the developing and adult brain
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作者：Enserink, Martin
摘要：Couple at Leiden University broke norms for 3 decades, investigators say
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作者：Holdaway, Jerrett; Georg, Gunda I.
作者单位：University of Minnesota System; University of Minnesota Twin Cities
摘要：An inhibitor of a nonhormonal target is identified using a DNA-encoded chemical library
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作者：Cornwall, Warren
摘要：After $50 million upgrade, U.S. research sub can reach 99% of the ocean floor
