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作者：Shen, Xiangjin; Jiang, Ming; Lu, Xianguo; Thompson, Julian R.
作者单位：Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; University of London; University College London
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作者：Mahadevan, Krishnan K.; Dyevoich, Allison M.; Chen, Yang; Li, Bingrui; Sugimoto, Hikaru; Sockwell, Amari M.; McAndrews, Kathleen M.; Sthanam, Lakshmi Kavitha; Wang, Huamin; Shalapour, Shabnam; Watowich, Stephanie S.; Kalluri, Raghu
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Rice University; Baylor College of Medicine
摘要：Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled with pancreatitis (ptPDAC), antigen-presenting type I conventional dendritic cells (cDC1s) are specifically activated. Immune checkpoint blockade therapy (iCBT) leads to cytotoxic CD8(+) T cell activation and elimination of ptPDAC with restoration of life span even upon PDAC rechallenge. Using PDAC antigen-loaded cDC1s a...
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作者：Aguilar, Hector C.
作者单位：Cornell University
摘要：Virus-cell membrane fusion is a critical process by which enveloped viruses enter host cells. For the paramyxoviruses, the viral family that measles virus (MeV) belongs to, the concerted efforts of two glycoproteins on the viral surface accomplish this goal. The first protein (G, H, or HN, depending on the virus) binds the host cell receptor. The second protein (the fusion protein F) is triggered by the first upon host receptor binding and executes fusion of the viral and cell membranes. Param...
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作者：Brainard, Jeffrey
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作者：Brinkerhoff, Craig B.; Gleason, Colin J.; Kotchen, Matthew J.; Kysar, Douglas A.; Raymond, Peter A.
作者单位：University of Massachusetts System; University of Massachusetts Amherst; Yale University; Yale University
摘要：Ephemeral streams flow only in direct response to precipitation and are ubiquitous landscape features. However, little is known about their influence on downstream rivers. Here, we modeled ephemeral stream water contributions to the contiguous United States network of more than 20 million rivers, lakes, and reservoirs, finding that ephemeral streams contribute, on average, 55% of the discharge exported from regional river systems, as defined by the United States Geological Survey. Our results ...
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作者：Whittaker, Madelynn N.; Musunuru, Kiran
作者单位：University of Pennsylvania
摘要：A new class of editor has improved delivery, durability, tunability, and safety
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作者：Herdy, Joseph R.; Mertens, Jerome; Gage, Fred H.
作者单位：Salk Institute; University of California System; University of California San Diego
摘要：Senescence of postmitotic neurons presents challenges and opportunities to modify brain aging
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作者：Voosen, Paul
摘要：Constellations of cheaper, more varied probes will track the atmosphere moment by moment, boosting forecasts
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作者：Xie, Fan; Tikhonov, Denis S.; Schnell, Melanie
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Kiel
摘要：Investigating the dissociation of acids in the presence of a limited number of water molecules is crucial for understanding various elementary chemical processes. In our study, focusing on HCl(H2O)(n) clusters (where HCl is hydrogen chloride and H2O is water) formed in a cold and isolated jet expansion, we used the nuclear quadrupole coupling tensor obtained through rotational spectroscopy to decipher the nature of the hydrogen-chlorine (H-Cl) chemical bond in a microaqueous environment. For n...
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作者：Stokstad, Erik
摘要：First synthetic gene drive for plants could help tame weeds-or transform them
