Antibody inhibition of measles virus entry

• 成果类型: Editorial Material
• 署名作者: Aguilar, Hector C.
• 署名单位: Cornell University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8748
• DOI: 10.1126/science.adq3348
• 发表日期: 2024-06-28
• 页码: 1406-1407
• 关键词: fusion protein

摘要

Virus-cell membrane fusion is a critical process by which enveloped viruses enter host cells. For the paramyxoviruses, the viral family that measles virus (MeV) belongs to, the concerted efforts of two glycoproteins on the viral surface accomplish this goal. The first protein (G, H, or HN, depending on the virus) binds the host cell receptor. The second protein (the fusion protein F) is triggered by the first upon host receptor binding and executes fusion of the viral and cell membranes. Paramyxoviral infection also results in cellcell fusion (syncytia formation) mediated by the expression of the two viral glycoproteins on the cell surface and host cell receptors on adjacent cells ( 1 ). On page 1423 of this issue, Zyla et al. ( 2 ) used an antibody that binds MeV F to reveal a new intermediate step in the paramyxovirus fusion cascade during viral entry, simultaneously giving rise to a potential therapeutic.