作者：Szeto, Aydan C. H.; Clark, Paula A.; Ferreira, Ana C. F.; Heycock, Morgan; Griffiths, Emma L.; Jou, Eric; Mannion, Jonathan; Luan, Shi-Lu; Storrar, Sophie; Knolle, Martin D.; Kozik, Patrycja; Jolin, Helen E.; Fallon, Padraic G.; Mckenzie, Andrew N. J.
作者单位：MRC Laboratory Molecular Biology; University of Cambridge; Trinity College Dublin; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of Cambridge
摘要：Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s and T helper 2 cells to drive type-2 immunity during tissue repair, allergic disorders, and anti-helminth immunity. The control of this crucial up-regulation is poorly understood. Using CRISPR screens in ILCs we identified previously unappreciated myocyte-specific enhancer ...
作者：Zyla, Dawid S.; Della Marca, Roberta; Niemeyer, Gele; Zipursky, Gillian; Stearns, Kyle; Leedale, Cameron; Sobolik, Elizabeth B.; Callaway, Heather M.; Hariharan, Chitra; Peng, Weiwei; Parekh, Diptiben; Marcink, Tara C.; Diaz Avalos, Ruben; Horvat, Branka; Mathieu, Cyrille; Snijder, Joost; Greninger, Alexander L.; Hastie, Kathryn M.; Niewiesk, Stefan; Moscona, Anne; Porotto, Matteo; Saphire, Erica Ollmann
作者单位：La Jolla Institute for Immunology; Columbia University; Columbia University; Universita della Campania Vanvitelli; University of Lubeck; University System of Ohio; Ohio State University; University of Washington; University of Washington Seattle; Utrecht University; Utrecht University; Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Columbia University; Columbia University; University of California System; University of California San Diego; Montana State University System; Montana State University Bozeman
摘要：Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the generalpopulation declines and as populations of immunocompromised individuals, who cannot be vaccinated,increase. There are no approved therapeutics for MeV. Neutralizing antibodies targeting viral fusionare one potential therapeutic approach but have not yet been structurally characterized or advanced toclinical use. We present cryo-electron microscopy (cryo-EM) structures of prefusion F alone [...
