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作者：Harvey, Judson W.; Kampf, Stephanie K.
作者单位：United States Department of the Interior; United States Geological Survey; Colorado State University System; Colorado State University Fort Collins
摘要：A river's journey typically starts in temporary streams that flow sporadically when wet conditions prevail. During dry periods, streamflow slows and then stops as the waters recede below ground. When streamflow resumes over recently dry streambeds, it mobilizes and transports energy-rich materials and nutrients that stimulate aquatic ecosystem productivity downstream ( 1 ). Temporary streams are present in all climate zones ( 1 - 3 ), and most of the world's streams and rivers do not flow cont...
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作者：Neumann, Edwin N.; Bertozzi, Tessa M.; Wu, Elaine; Serack, Fiona; Harvey, John W.; Brauer, Pamela P.; Pirtle, Catherine P.; Coffey, Alissa; Howard, Michael; Kamath, Nikita; Lenz, Kenney; Guzman, Kenia; Raymond, Michael H.; Khalil, Ahmad S.; Deverman, Benjamin E.; Minikel, Eric Vallabh; Vallabh, Sonia M.; Weissman, Jonathan S.
作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Boston University; Boston University; Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression. In this study, we describe Coupled Histone tail for Autoinhibition Release of Methyltransferase (CHARM), a compact, enzyme-free epigenetic editor capable of silencing transcription through programmable DNA methylation. Using a histone H3 tail-Dnmt3l fusion, CHARM recrui...
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作者：Winnikoff, Jacob R.; Milshteyn, Daniel; Vargas-Urbano, Sasiri J.; Pedraza-Joya, Miguel A.; Armando, Aaron M.; Quehenberger, Oswald; Sodt, Alexander; Gillilan, Richard E.; Dennis, Edward A.; Lyman, Edward; Haddock, Steven H. D.; Budin, Itay
作者单位：University of California System; University of California San Diego; Harvard University; Monterey Bay Aquarium Research Institute; University of California System; University of California Santa Cruz; University of Delaware; University of California System; University of California San Diego; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
摘要：Hydrostatic pressure increases with depth in the ocean, but little is known about the molecular bases of biological pressure tolerance. We describe a mode of pressure adaptation in comb jellies (ctenophores) that also constrains these animals' depth range. Structural analysis of deep-sea ctenophore lipids shows that they form a nonbilayer phase at pressures under which the phase is not typically stable. Lipidomics and all-atom simulations identified phospholipids with strong negative spontaneo...
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作者：Zhao, Xiaoli; Wu, Xiaowei; Yu, Dandan; Lundquist, Carolyn; Li, Chengjun; Zhong, Huan
作者单位：Chinese Research Academy of Environmental Sciences; Nanjing University of Information Science & Technology; Nanjing Institute of Environmental Sciences, Ministry of Ecology & Environment; University of Auckland; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Guangzhou University; Nanjing University; Trent University
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作者：Hu, Yiming; Sengupta, Bratin; Long, Hai; Wayment, Lacey J.; Ciora, Richard; Jin, Yinghua; Wu, Jingyi; Lei, Zepeng; Friedman, Kaleb; Chen, Hongxuan; Yu, Miao; Zhang, Wei
作者单位：University of Colorado System; University of Colorado Boulder; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA
摘要：Crystalline materials with uniform molecular-sized pores are desirable for a broad range of applications, such as sensors, catalysis, and separations. However, it is challenging to tune the pore size of a single material continuously and to reversibly distinguish small molecules (below 4 angstroms). We synthesized a series of ionic covalent organic frameworks using a tetraphenoxyborate linkage that maintains meticulous synergy between structural rigidity and local flexibility to achieve contin...
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作者：Fujii, Michiko S.; Wang, Long; Tanikawa, Ataru; Hirai, Yutaka; Saitoh, Takayuki R.
作者单位：University of Tokyo; Sun Yat Sen University; Fukui Prefectural University; University of Notre Dame; Tohoku University; Kobe University
摘要：The formation process of intermediate-mass black holes (IMBHs), defined as those between 100 and 10(5) solar masses (M (circle dot)), is debated. One potential origin is the growth of less-massive black holes merging with stars and compact objects within globular clusters (GCs). However, previous simulations have indicated that this process only produces IMBHs under 500 M (circle dot) before gravitational wave recoil ejects them from the GC. We performed star-by-star simulations of GC formatio...
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作者：Goebel, Luan Gabriel Araujo; Pfeil, Cello Latini; Gois, Isis; Rodrigues, Felipe Behrends; Pagan, Alice Alexandre; de Souza, Lucy Gomes
作者单位：Universidade do Estado de Mato Grosso; Universidade Federal do Rio de Janeiro; Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Mato Grosso; Universidade Federal de Amazonas
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作者：Luo, Lubin; Younker, Jarod M.; Zabula, Alexander V.
摘要：Methylaluminoxane (MAO) is used as a precatalyst activator for million ton-scale production of commercial polyolefins, but its precise structure and associated activation mechanisms have been a fundamental research puzzle for more than 40 years. We report here the crystallographic characterization of an active MAO component, which reveals a discrete two-dimensional sheet cluster [Al33O26(CH3)(47)][Al(CH3)(3)](2) featuring two trimethylaluminum units, Al(CH3)(3), coordinated to two unsaturated ...
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作者：Wang, Yidong; Qiu, Liang; Wang, Bing; Guan, Zeyuan; Dong, Zhi; Zhang, Jie; Cao, Song; Yang, Lulu; Wang, Bo; Gong, Zhou; Zhang, Liwei; Ma, Weihua; Liu, Zhu; Zhang, Delin; Wang, Guirong; Yin, Ping
作者单位：Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Hubei Hongshan Laboratory; Huazhong Agricultural University; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; China Agricultural University
摘要：Insects detect and discriminate a diverse array of chemicals using odorant receptors (ORs), which are ligand-gated ion channels comprising a divergent odorant-sensing OR and a conserved odorant receptor co-receptor (Orco). In this work, we report structures of the ApOR5-Orco heterocomplex from the pea aphid Acyrthosiphon pisum alone and bound to its known activating ligand, geranyl acetate. In these structures, three ApOrco subunits serve as scaffold components that cannot bind the ligand and ...
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作者：Brainard, Jeffrey
