6715期

最新文章

• Artificial kinetochore beads establish a biorientation-like state in the spindle AI翻译
  作者：Asai, Kohei; Zhou, Yuanzhuo; Takenouchi, Osamu; Kitajima, Tomoya S.
  作者单位：RIKEN; Kyoto University
  摘要：Faithful chromosome segregation requires biorientation, where the pair of kinetochores on the chromosome establish bipolar microtubule attachment. The integrity of the kinetochore, a macromolecular complex built on centromeric DNA, is required for biorientation, but components sufficient for biorientation remain unknown. Here, we show that tethering the outer kinetochore heterodimer NDC80-NUF2 to the surface of apolar microbeads establishes their biorientation-like state in mouse cells. NDC80-...
• Suit against data sleuths nixed AI翻译
  作者：Brainard, Jeffrey; Servick, Kelly
• The global war on island rats AI翻译
  作者：Pennisi, Elizabeth
  摘要：Invasive rodents wreak havoc on island wildlife. How we learned to fight back
• New neutrino detector turns on AI翻译
  作者：Brainard, Jeffrey; Servick, Kelly
• KRAS takes the road to destruction AI翻译
  作者：Cox, Adrienne D.; Der, Channing J.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：A single small molecule degrades numerous KRAS variants involved in cancer
• Who cares about lab rodents? AI翻译
  作者：Davies, Gail; Kirk, Robert G. W.; Greenhough, Beth; Hobson-West, Pru; Myelnikov, Dmitriy; Roe, Emma
  作者单位：University of Exeter; University of Manchester; University of Oxford; University of Nottingham; University of Cambridge; University of Southampton
  摘要：Rodents are widely seen as a commensal pest species and an unwelcome addition to human society. Consequently, caring about mice and rats-relative to more charismatic species, such as cats or dogs-is less commonly a focus of public concern. Yet, in discussions around rodents in research, questions of care are prominent. This prompts the question, who cares about rodents in research? To answer this, we draw on recent research from across the humanities and social sciences that seeks to better un...
• A 485-million-year history of Earth's surface temperature AI翻译
  作者：Judd, Emily J.; Tierney, Jessica E.; Lunt, Daniel J.; Montanez, Isabel P.; Huber, Brian T.; Wing, Scott L.; Valdes, Paul J.
  作者单位：Smithsonian Institution; Smithsonian National Museum of Natural History; University of Arizona; University of Bristol; University of California System; University of California Davis; Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS
  摘要：A long-term record of global mean surface temperature (GMST) provides critical insight into the dynamical limits of Earth's climate and the complex feedbacks between temperature and the broader Earth system. Here, we present PhanDA, a reconstruction of GMST over the past 485 million years, generated by statistically integrating proxy data with climate model simulations. PhanDA exhibits a large range of GMST, spanning 11 degrees to 36 degrees C. Partitioning the reconstruction into climate stat...
• Hot and cold Earth through time AI翻译
  作者：Mills, Benjamin J. W.
  作者单位：University of Leeds
  摘要：Reconstructing ancient Earth's temperature reveals a global climate regulation system
• Postdocs on visas get less pay AI翻译
  作者：Brainard, Jeffrey; Servick, Kelly
• Early education's long-term benefits AI翻译
  作者：Garcia, Jorge Luis
  作者单位：Texas A&M University System; Texas A&M University College Station