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作者：Lynteris, Christos
作者单位：University of St Andrews
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作者：Aso, Yoichi
作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ)
摘要：The detection of ripples in spacetime, which are known as gravitational waves (GWs), has emerged as a critical frontier in modern astrophysics. Indeed, kilometer-scale detectors, such as the Laser Interferometer Gravitational-Wave Observatory (LIGO), have provided insights into energetic astronomical events, including the mergers of black holes and neutron stars. It is remarkable that the sensitivity of such large detectors is limited by quantum-mechanical fluctuations, which usually become re...
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作者：Keesing, Felicia; Ostfeld, Richard S.
作者单位：Cary Institute of Ecosystem Studies
摘要：Rodents are ubiquitous and typically unwelcome dwellers in human habitats worldwide, infesting homes, farm fields, and agricultural stores and potentially shedding disease-causing microbes into the most human-occupied of spaces. Of the vertebrate animal taxa that share pathogens with us, rodents are the most abundant and diverse, with hundreds of species of confirmed zoonotic hosts, some of which have nearly global distributions. However, only 12% of rodent species are known to be sources of p...
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作者：Popow, Johannes; Farnaby, William; Gollner, Andreas; Kofink, Christiane; Fischer, Gerhard; Wurm, Melanie; Zollman, David; Wijaya, Andre; Mischerikow, Nikolai; Hasenoehrl, Carina; Prokofeva, Polina; Arnhof, Heribert; Arce-Solano, Silvia; Bell, Sammy; Boeck, Georg; Diers, Emelyne; Frost, Aileen B.; Goodwin-Tindall, Jake; Karolyi-Oezguer, Jale; Khan, Shakil; Klawatsch, Theresa; Koegl, Manfred; Kousek, Roland; Kratochvil, Barbara; Kropatsch, Katrin; Lauber, Arnel A.; Mclennan, Ross; Olt, Sabine; Peter, Daniel; Petermann, Oliver; Roessler, Vanessa; Stolt-Bergner, Peggy; Strack, Patrick; Strauss, Eva; Trainor, Nicole; Vetma, Vesna; Whitworth, Claire; Zhong, Siying; Quant, Jens; Weinstabl, Harald; Kuster, Bernhard; Ettmayer, Peter; Ciulli, Alessio
作者单位：Boehringer Ingelheim; University of Dundee; University of Dundee; Technical University of Munich; Boehringer Ingelheim
摘要：Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein are highly prevalent in cancer. However, small-molecule concepts that address oncogenic KRAS alleles remain elusive beyond replacing glycine at position 12 with cysteine (G12C), which is clinically drugged through covalent inhibitors. Guided by biophysical and structural studies of ternary complexes, we designed a heterobifunctional small molecule that potently degrades 13 out of 17 of the most prevalent oncogenic KRAS ...
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作者：Brainard, Jeffrey; Servick, Kelly
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作者：Ash, Caroline; Lopez, Bianca; Vignieri, Sacha; Wible, Brad
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作者：Simkovic IV, Fedor; Rossi, Riccardo; Georges, Antoine; Ferrero, Michel
作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Universite PSL; College de France; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Simons Foundation; Flatiron Institute; University of Geneva
摘要：The relationship between the pseudogap and underlying ground-state phases has not yet been rigorously established. We investigated the doped two-dimensional Hubbard model at finite temperature using controlled diagrammatic Monte Carlo calculations, allowing for the computation of spectral properties in the infinite-size limit and with arbitrary momentum resolution. We found three distinct regimes as a function of doping and interaction strength: a weakly correlated metal, a correlated metal wi...
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作者：Munshi-South, Jason; Garcia, Joseph A.; Orton, David; Phifer-Rixey, Megan
作者单位：Drexel University; NewYork-Presbyterian Hospital; Columbia University; University of York - UK; Drexel University
摘要：The brown rat (Rattus norvegicus) occupies nearly every terrestrial habitat with a human presence and is one of our most important model organisms. Despite this prevalence, gaps remain in understanding the evolution of brown rat commensalism, their global dispersal, and mechanisms underlying contemporary adaptations to diverse environments. In this Review, we explore recent advances in the evolutionary history of brown rats and discuss key challenges, including finding and accurately dating hi...
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作者：Brainard, Jeffrey; Servick, Kelly
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作者：Brainard, Jeffrey; Servick, Kelly
