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作者：Jia, Wenxuan; Xu, Victoria; Kuns, Kevin; Nakano, Masayuki; Barsotti, Lisa; Evans, Matthew; Mavalvala, Nergis
作者单位：Massachusetts Institute of Technology (MIT)
摘要：The Heisenberg uncertainty principle dictates that the position and momentum of an object cannot be simultaneously measured with arbitrary precision, giving rise to an apparent limitation known as the standard quantum limit (SQL). Gravitational-wave detectors use photons to continuously measure the positions of freely falling mirrors and so are affected by the SQL. We investigated the performance of the Laser Interferometer Gravitational-Wave Observatory (LIGO) after the experimental realizati...
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作者：Andrews, Robin George
摘要：Beneath Europa's icy crust is a salty ocean, perhaps the best place in the Solar System to look for life. A NASA spacecraft will soon set off to probe the jovian moon
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作者：Liu, Fangyu; Wu, Cheng-Guo; Tu, Chia-Ling; Glenn, Isabella; Meyerowitz, Justin; Kaplan, Anat Levit; Lyu, Jiankun; Cheng, Zhiqiang; Tarkhanova, Olga O.; Moroz, Yurii S.; Irwin, John J.; Chang, Wenhan; Shoichet, Brian K.; Skiniotis, Georgios
作者单位：University of California System; University of California San Francisco; Stanford University; University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA); San Francisco VA Medical Center; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv; Enamine Ltd; Stanford University; Rockefeller University
摘要：Positive allosteric modulator (PAM) drugs enhance the activation of the calcium-sensing receptor (CaSR) and suppress parathyroid hormone (PTH) secretion. Unfortunately, these hyperparathyroidism-treating drugs can induce hypocalcemia and arrhythmias. Seeking improved modulators, we docked libraries of 2.7 million and 1.2 billion molecules against the CaSR structure. The billion-molecule docking found PAMs with a 2.7-fold higher hit rate than the million-molecule library, with hits up to 37-fol...
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作者：Huang, Zhidao; Akana, Michelle E.; Sanders, Kyana M.; Weix, Daniel J.
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：The myriad nickel-catalyzed cross-coupling reactions rely on the formation of an organonickel intermediate, but limitations in forming monoalkylnickel species have limited options for C(sp(3)) cross-coupling. The formation of monoalkylnickel(II) species from abundant carboxylic acid esters would be valuable, but carboxylic acid derivatives are primarily decarboxylated to form alkyl radicals that lack the correct reactivity. In this work, we disclose a facile oxidative addition and decarbonylat...
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作者：Wadman, Meredith
摘要：Fearmongering guidelines ignore wealth of scientific evidence, critics say
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作者：Davidson, Ian J.
作者单位：Concordia University of Edmonton
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作者：Zare, Richard N.
作者单位：Stanford University
摘要：Groundbreaking physical organic chemist
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作者：McPherson, Rebecca Adam; Wekerle, Claudia; Kanzow, Torsten; Ionita, Monica; Heukamp, Finn Ole; Zeising, Ole; Humbert, Angelika
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Bremen; Stefan cel Mare University of Suceava; University of Bremen
摘要：Mass loss from the Greenland ice sheet has contributed to global sea-level rise over the past 20 years. Yet direct observations from the 79 North Glacier (79NG) calving front reveal decreasing Atlantic Intermediate Water (AIW) temperatures below the ice tongue from 2018 to 2021, leading to reduced ocean heat transport. This is linked to a concurrent decrease in basal melt and thinning rates at the grounding line. The origin of this AIW cooling is traced to a slowdown of the large-scale ocean c...
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作者：Ryan-Anderson, C.; Brown, N. C.; Baldwin, C. H.; Dreiling, J. M.; Foltz, C.; Gaebler, J. P.; Gatterman, T. M.; Hewitt, N.; Holliman, C.; Horst, C. V.; Johansen, J.; Lucchetti, D.; Mengle, T.; Matheny, M.; Matsuoka, Y.; Mayer, K.; Mills, M.; Moses, S. A.; Neyenhuis, B.; Pino, J.; Siegfried, P.; Stutz, R. P.; Walker, J.; Hayes, D.
摘要：Quantum state teleportation is commonly used in designs for large-scale quantum computers. Using Quantinuum's H2 trapped-ion quantum processor, we demonstrate fault-tolerant state teleportation circuits for a quantum error correction code-specifically the Steane code. The circuits use up to 30 qubits at the physical level and employ real-time quantum error correction. We conducted experiments on several variations of logical teleportation circuits using both transversal gates and lattice surge...
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作者：Zhao, Jiantao; Yu, Huacheng; Jin, Xingchen; Qin, Bo; Mei, Shan; Xu, Jiang-Fei; Zhang, Xi
作者单位：Tsinghua University
摘要：Click reactions, which are characterized by rapid, high-yielding, and highly selective coupling of two reaction partners, are powerful tools in synthesis but are rarely reversible. Innovative strategies that reverse such couplings in a precise and on-demand manner, enabling a click-clip sequence, would greatly expand the technique's versatility. Herein, a click and clip reaction pair is demonstrated by manipulation of a sulfilimine linkage. Phenothiazines and amines are rapidly and quantitativ...
