6716期

最新文章

• The microbiome and human cancer (Sep, 10.1126/science.adt2260, 2024) AI翻译
  作者：Sepich-Poore, G. D.
• Pronouns reactivate conceptual representations in human hippocampal neurons AI翻译
  作者：Dijksterhuis, D. E.; Self, M. W.; Possel, J. K.; Peters, J. C.; van Straaten, E. C. W.; Idema, S.; Baaijen, J. C.; van der Salm, S. M. A.; Aarnoutse, E. J.; van Klink, N. C. E.; van Eijsden, P.; Hanslmayr, S.; Chelvarajah, R.; Roux, F.; Kolibius, L. D.; Sawlani, V.; Rollings, D. T.; Dehaene, S.; Roelfsema, P. R.
  作者单位：Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); Maastricht University; Maastricht University; Eindhoven University of Technology; Utrecht University; Utrecht University Medical Center; University of Glasgow; University of Birmingham; University of Birmingham; Columbia University; Universite Paris Saclay; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; College de France; Vrije Universiteit Amsterdam; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition and utterance length, languages use pronouns, like the word she, to refer to nouns and phrases that were previously introduced. It has been suggested that language comprehension requires that pronouns activate the same neuronal representations as the nouns themselves. We recorded from individual neurons in...
• How wet must a wetland be to have federal protections in post-Sackett US? AI翻译
  作者：Gold, Adam C.
  作者单位：Environmental Defense Fund
  摘要：In 2023, the US Supreme Court's majority ruled in Sackett v. Environmental Protection Agency that only wetlands that are indistinguishable from federally protected waters due to a continuous surface connection are federally protected. This study estimates the potential impact of interpretations of the ruling on federal wetlands protections, using a qualitative measure of wetland wetness as a proxy for the new requirement. An estimated area ranging from similar to 17 million acres (19%) to near...
• A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency AI翻译
  作者：Lu, Qiuhe; Hitch, Thomas C. A.; Zhou, Julie Y.; Dwidar, Mohammed; Sangwan, Naseer; Lawrence, Dylan; Nolan, Lila S.; Espenschied, Scott T.; Newhall, Kevin P.; Han, Yi; Karell, Paul E.; Salazar, Vanessa; Baldridge, Megan T.; Clavel, Thomas; Stappenbeck, Thaddeus S.
  作者单位：Cleveland Clinic Foundation; RWTH Aachen University; RWTH Aachen University Hospital; Cleveland Clinic Foundation; Cleveland Clinic Foundation; Washington University (WUSTL)
  摘要：Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as Tomasiella immunophila, that induces and degrades IgA in the mouse intestine. Mice harboring T. immunophila are susceptible to infect...
• Rewiring movements: A single neuronal population in the spinal cord is crucial to restore walking after paralysis AI翻译
  作者：Kathe, Claudia
  作者单位：University of Lausanne
  摘要：Walking is seemingly effortless for most of us. We walk, run, and climb stairs without consciously thinking about each step. However, these simple movements require a highly complex interplay of muscle activations that consists of left-right leg alternation, coordinated muscle co-contractions, and inhibition of antagonistic muscle contractions. Even more fascinating is that stepping can be generated without any communication between the brain and the spinal cord. This property was demonstrated...
• Photochemical phosphorus-enabled scaffold remodeling of carboxylic acids AI翻译
  作者：Peng, Qiupeng; Hwang, Meemie U.; Renteria-Gomez, Angel; Mukherjee, Poulami; Young, Ryan M.; Qiu, Yunfan; Wasielewski, Michael R.; Gutierrez, Osvaldo; Scheidt, Karl A.
  作者单位：Northwestern University; Texas A&M University System; Texas A&M University College Station; Northwestern University
  摘要：The excitation of carbonyl compounds by light to generate radical intermediates has historically been restricted to ketones and aldehydes; carboxylic acids have been overlooked because of high energy requirements and low quantum efficiency. A successful activation strategy would necessitate a bathochromic shift in the absorbance profile, an increase in triplet diradical lifetime, and ease of further functionalization. We present a single-flask transformation of carboxylic acids to acyl phospho...
• Gut microbe may ward off altitude sickness: Finding adds to evidence that one set of gut bacteria has diverse benefits AI翻译
  作者：Pennisi, Elizabeth
• Food for thought: The molecular basis of nutrient uptake into the brain AI翻译
  作者：Cater, Rosemary J.
  作者单位：University of Queensland
  摘要：The brain is our most important and sophisticated organ. To develop this organ-all the way from an embryo to an adult brain, with its hundreds of billions of neurons and glial cells and 400 miles of vasculature-is no small task. Each mammalian cell contains more than one billion phospholipids. More than half of these lipids are phosphatidylcholine. The sheer density of cells in the brain endows it with an immense hunger for this critical cellular component. In 1956, Eugene P. Kennedy discovere...
• Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex AI翻译
  作者：Hao, Shijie; Zhu, Xiaojia; Huang, Zhi; Yang, Qianqian; Liu, Hean; Wu, Yan; Zhan, Yafeng; Dong, Yu; Li, Chao; Wang, He; Haasdijk, Elize; Wu, Zihan; Li, Shenglong; Yan, Haotian; Zhu, Lijing; Guo, Shiyong; Wang, Zefang; Ye, Aojun; Lin, Youning; Cui, Luman; Tan, Xing; Liu, Huanlin; Wang, Mingli; Chen, Jing; Zhong, Yanqing; Du, Wensi; Wang, Guangling; Lai, Tingting; Cao, Mengdi; Yang, Tao; Xu, Yuanfang; Li, Ling; Yu, Qian; Zhuang, Zhenkun; Xia, Ying; Lei, Ying; An, Yingjie; Cheng, Mengnan; Zhao, Yun; Han, Lei; Yuan, Yue; Song, Xinxiang; Song, Yumo; Gu, Liqin; Liu, Chang; Lin, Xiumei; Wang, Ruiqi; Wang, Zhifeng; Wang, Yang; Li, Shenyu; Li, Huanhuan; Song, Jingjing; Chen, Mengni; Zhou, Wanqiu; Yuan, Nini; Sun, Suhong; Wang, Shiwen; Chen, Yu; Zheng, Mingyuan; Fang, Jiao; Zhang, Ruiyi; Zhang, Shuzhen; Chai, Qinwen; Liu, Jiabing; Wei, Wu; He, Jie; Zhou, Haibo; Sun, Yangang; Liu, Zhen; Liu, Chuanyu; Yao, Jianhua; Liang, Zhifeng; Xu, Xun; Poo, Muming; Li, Chengyu; De Zeeuw, Chris I.; Shen, Zhiming; Liu, Zhiyong; Liu, Longqi; Liu, Shiping; Sun, Yidi; Liu, Cirong
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Beijing Genomics Institute (BGI); South China University of Technology; Lingang Laboratory; Erasmus University Rotterdam; Erasmus MC; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); Tencent; Beijing Genomics Institute (BGI); Shanxi Medical University; Shanghai Center for Brain Science & Brain-Inspired Technology
  摘要：The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 (GRID2) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in a...
• Picture imperfect AI翻译
  作者：Piller, Charles