作者：Joyce, William; He, Kai; Zhang, Mengdie; Ogunsola, Samuel; Wu, Xini; Joseph, Kelvin T.; Bogomolny, David; Yu, Wenhua; Springer, Mark S.; Xie, Jiuyong; Signore, Anthony V.; Campbell, Kevin L.
作者单位：Aarhus University; University of Manchester; Guangzhou University; University of Manitoba; University of Manitoba; University of California System; University of California Riverside; Centro Nacional de Investigaciones Cardiovasculares (CNIC)
摘要：Mammalian cardiac troponin I (cTnI) contains a highly conserved amino-terminal extension harboring protein kinase A targets [serine-23 and -24 (Ser(23/24))] that are phosphorylated during beta-adrenergic stimulation to defend diastolic filling by means of an increased cardiomyocyte relaxation rate. In this work, we show that the Ser(23/24)-encoding exon 3 of TNNI3 was pseudoexonized multiple times in shrews and moles to mimic Ser(23/24) phosphorylation without adrenergic stimulation, facilitat...
作者：Darling, Seth B.
作者单位：United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago
作者：Landim-Vieira, Maicon; Pinto, Jose Renato
作者单位：State University System of Florida; Florida State University
