作者：Lau, Andy M.; Bordin, Nicola; Kandathil, Shaun M.; Sillitoe, Ian; Waman, Vaishali P.; Wells, Jude; Orengo, Christine A.; Jones, David T.
作者单位：University of London; University College London; University of London; University College London; Birkbeck University London; University of London; University College London
摘要：The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and functional contexts. Identifying domains can enable many functional and evolutionary analyses but has remained challenging because of the sheer scale of the data. Using deep learning methods, we have detected and classified every domain in the AFDB, producing The Encyclopedia of Domains. We detect...
作者：Barron, Jerika J.; Mroz, Nicholas M.; Taloma, Sunrae E.; Dahlgren, Madelene W.; Ortiz-Carpena, Jorge F.; Keefe, Matthew G.; Escoubas, Caroline C.; Dorman, Leah C.; Vainchtein, Ilia D.; Chiaranunt, Pailin; Kotas, Maya E.; Nowakowski, Tomasz J.; Bender, Kevin J.; Molofsky, Ari B.; Molofsky, Anna V.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Lund University; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. In this work, we found that group 2 innate lymphoid cells (ILC2s) and their cytokine interleukin-13 (IL-13) signaled directly to inhibitory interneurons to increase inhibitory synapse density in the developing mouse brain. ILC2s expanded and produced IL-13 in the developing brain meninges. Loss of ...
作者：Green, Miranda; Foster, Jane A.
作者单位：McMaster University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
作者：Kraft, Florian; Rodriguez-Aliaga, Piere; Yuan, Weimin; Franken, Lena; Zajt, Kamil; Hasan, Dimah; Lee, Ting-Ting; Flex, Elisabetta; Hentschel, Andreas; Innes, A. Micheil; Zheng, Bixia; Suh, Dong Sun Julia; Knopp, Cordula; Lausberg, Eva; Krause, Jeremias; Zhang, Xiaomeng; Trapane, Pamela; Carroll, Riley; Mcclatchey, Martin; Fry, Andrew E.; Wang, Lisa; Giesselmann, Sebastian; Hoang, Hieu; Baldridge, Dustin; Silverman, Gary A.; Radio, Francesca Clementina; Bertini, Enrico; Ciolfi, Andrea; Blood, Katherine A.; Agathe, Jean-Madeleine de Sainte; Charles, Perrine; Bergant, Gaber; Cuturilo, Goran; Peterlin, Borut; Diderich, Karin; Streff, Haley; Robak, Laurie; Oegema, Renske; van Binsbergen, Ellen; Herriges, John; Saunders, Carol J.; Maier, Andrea; Wolking, Stefan; Weber, Yvonne; Lochmuller, Hanns; Meyer, Stefanie; Aleman, Alberto; Polavarapu, Kiran; Nicolas, Gael; Goldenberg, Alice; Guyant, Lucie; Pope, Kathleen; Hehmeyer, Katherine N.; Monaghan, Kristin G.; Quade, Annegret; Smol, Thomas; Caumes, Roseline; Duerinckx, Sarah; Depondt, Chantal; Van Paesschen, Wim; Rieubland, Claudine; Poloni, Claudia; Guipponi, Michel; Arcioni, Severine; Meuwissen, Marije; Jansen, Anna C.; Rosenblum, Jessica; Haack, Tobias B.; Bertrand, Miriam; Gerstner, Lea; Magg, Janine; Riess, Olaf; Schulz, Joerg B.; Wagner, Norbert; Wiesmann, Martin; Weis, Joachim; Eggermann, Thomas; Begemann, Matthias; Roos, Andreas; Haeusler, Martin; Schedl, Tim; Tartaglia, Marco; Bremer, Juliane; Pak, Stephen C.; Frydman, Judith; Elbracht, Miriam; Kurth, Ingo
作者单位：RWTH Aachen University; Stanford University; Washington University (WUSTL); RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Calgary; University of Calgary; Nanjing Medical University; State University System of Florida; University of Florida; Cardiff University; Cardiff University; IRCCS Bambino Gesu; IRCCS Bambino Gesu; University of British Columbia; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Sorbonne Universite; University Medical Centre Ljubljana; University of Belgrade; University of Belgrade; Erasmus University Rotterdam; Erasmus MC; Baylor College of Medicine; Utrecht University; Utrecht University Medical Center; Children's Mercy Hospital; University of Missouri System; University of Missouri Kansas City; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; University of Ottawa; Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario; University of Ottawa; National Institute of Mental Health & Neurosciences - India; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Rouen Normandie; Universite de Rouen Normandie; CHU de Rouen; State University System of Florida; University of South Florida; RWTH Aachen University; RWTH Aachen University Hospital; Universite de Lille; CHU Lille; Universite Libre de Bruxelles; Universite Libre de Bruxelles; KU Leuven; KU Leuven; University Hospital Leuven; University of Geneva; University of Geneva; University of Antwerp; University of Antwerp; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; TUBINGEN UNIVERSITY CHILDRENS HOSPITAL; RWTH Aachen University; RWTH Aachen University Hospital; University of Duisburg Essen; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Washington University (WUSTL)
摘要：Malformations of the brain are common and vary in severity, from negligible to potentially fatal. Their causes have not been fully elucidated. Here, we report pathogenic variants in the core protein-folding machinery TRiC/CCT in individuals with brain malformations, intellectual disability, and seizures. The chaperonin TRiC is an obligate hetero-oligomer, and we identify variants in seven of its eight subunits, all of which impair function or assembly through different mechanisms. Transcriptom...
作者：Li, Ziqiang P.; Moreau, Hortense; Petit, Jules D.; Moraes, Tatiana S.; Smokvarska, Marija; Perez-Sancho, Jessica; Petrel, Melina; Decoeur, Fanny; Brocard, Lysiane; Chambaud, Clement; Grison, Magali S.; Paterlini, Andrea; Glavier, Marie; Hoornaert, Lucie; Joshi, Amit S.; Gontier, Etienne; Prinz, William A.; Jaillais, Yvon; Taly, Antoine; Campelo, Felix; Caillaud, Marie-Cecile; Bayer, Emmanuelle M.
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Bordeaux; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); INRAE; University of Tennessee System; University of Tennessee Knoxville; University of Texas System; University of Texas Dallas; University of Texas Southwestern Medical Center; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite Paris Cite; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); University of Edinburgh
摘要：Diverging from conventional cell division models, plant cells undergo incomplete division to generate plasmodesmata communication bridges between daughter cells. Although fundamental for plant multicellularity, the molecular events leading to bridge stabilization, as opposed to severing, remain unknown. Using electron tomography, we mapped the transition from cell plate fenestrae to plasmodesmata. We show that the endoplasmic reticulum (ER) connects daughter cells across fenestrae, and as the ...
