6721期

最新文章

• Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome AI翻译
  作者：Rogalska, Malgorzata E.; Mancini, Estefania; Bonnal, Sophie; Gohr, Andre; Dunyak, Bryan M.; Arecco, Niccolo; Smith, Peter G.; Vaillancourt, Frederic H.; Valcarcel, Juan
  作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; ICREA; Max Planck Society
  摘要：The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process altered in numerous pathologies. We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks that govern different classes of alternative splicing decisions. The results d...
• Keeping outbreaks at bay An epidemiologist interrogates the often unseen work of mitigating disease spread AI翻译
  作者：Long, Kanya
  作者单位：University of California System; University of California San Diego
• Secure ancient animal remains from permafrost AI翻译
  作者：Ramos, Raul; Plotnikov, Valerii; Cheprasov, Maksim Y.; Plikus, Maksim V.
  作者单位：University of California System; University of California Irvine; North-Eastern Federal University in Yakutsk
• Can Islam and science coexist? AI翻译
  作者：[Anonymous]
• Policy evaluation and the causal analysis of public support AI翻译
  作者：Carattini, Stefano; Dur, Robert; List, John
  作者单位：University System of Georgia; Georgia State University; Erasmus University Rotterdam; Erasmus University Rotterdam - Excl Erasmus MC; University of Chicago
• You won't believe this AI翻译
  作者：Kupferschmidt, Kai
• A self-regenerative heat pump based on a dual-functional relaxor ferroelectric polymer AI翻译
  作者：Wu, Hanxiang; Zhu, Yuan; Yan, Wenzhong; Zhang, Siyu; Budiman, William; Liu, Kede; Wu, Jianghan; Meng, Yuan; Zhao, Xun; Mehta, Ankur; Kaur, Sumanjeet; Pei, Qibing
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Electrocaloric (EC) cooling presents a promising approach to efficient and compact solid-state heat pumps. However, reported EC coolers have complex architectures and limited cooling temperature lift. In this work, we introduce a self-regenerative heat pump (SRHP) using a cascade of EC polymer film stacks, which have electrostrictive actuations in response to an electric field that are directed to realize efficient heat transfer, eliminating the need for additional transportive or regenerative...
• Age effects challenge psychiatric research AI翻译
  作者：Chen, Ke; Sun, Yu; Ni, Tong; Zhu, Li; Gui, Hongsheng; Guan, Fanglin
  作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; Shandong University; Henry Ford Health System; Michigan State University
• Risks of Morocco's green hydrogen plans AI翻译
  作者：Hussein, Hussam; Schuetze, Benjamin
  作者单位：University of Oxford; University of Freiburg
• Latin America sets out to end neglect of rare diseases Network aims to raise awareness and bolster testing and treatment for rare genetic conditions AI翻译
  作者：Valero, Myriam Vidal