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作者：Brito, Claudia; Serna, Marina; Guerra, Pablo; Llorca, Oscar; Surrey, Thomas
作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Centro Nacional de Investigaciones Oncologicas (CNIO); Pompeu Fabra University; ICREA
摘要：Microtubules are essential for intracellular organization and chromosome segregation. They are nucleated by the gamma-tubulin ring complex (gamma TuRC). However, isolated vertebrate gamma TuRC adopts an open conformation that deviates from the microtubule structure, raising the question of the nucleation mechanism. In this study, we determined cryo-electron microscopy structures of human gamma TuRC bound to a nascent microtubule. Structural changes of the complex into a closed conformation ens...
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作者：Wai, Jonathan
作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
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作者：Yang, Yi; Yang, Biao; Ma, Guancong; Li, Jensen; Zhang, Shuang; Chan, C. T.
作者单位：University of Hong Kong; University of Hong Kong; National University of Defense Technology - China; National University of Defense Technology - China; National University of Defense Technology - China; Hong Kong Baptist University; Hong Kong University of Science & Technology; University of Hong Kong; University of Hong Kong
摘要：Non-Abelian phenomena arise when the sequence of operations on physical systems influences their behaviors. By possessing internal degrees of freedom such as polarization, light and sound can be subjected to various manipulations, including constituent materials, structured environments, and tailored source conditions. These manipulations enable the creation of a great variety of Hamiltonians, through which rich non-Abelian phenomena can be explored and observed. Recent developments have const...
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作者：[Anonymous]
摘要：Awards recognize contributions to science diplomacy, mentoring, public engagement, and more
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Huppertz, Magnus-Carsten; Wilhelm, Jonas; Grenier, Vincent; Schneider, Martin W.; Falt, Tjalda; Porzberg, Nicola; Hausmann, David; Hoffmann, Dirk C.; Hai, Ling; Tarnawski, Miroslaw; Pino, Gabriela; Slanchev, Krasimir; Kolb, Ilya; Acuna, Claudio; Fenk, Lisa M.; Baier, Herwig; Hiblot, Julien; Johnsson, Kai
作者单位：Max Planck Society; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; National Center for Tumor Diseases; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Max Planck Society; Ruprecht Karls University Heidelberg; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins that become labeled in the presence of both a specific cellular activity and a fluorescent substrate. The recording period is set by the presence of the substrate, whereas the cellular activity controls the degree of the labeling. The use of d...
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作者：Hoge, Carla; de Manuel, Marc; Mahgoub, Mohamed; Okami, Naima; Fuller, Zachary; Banerjee, Shreya; Baker, Zachary; Mcnulty, Morgan; Andolfatto, Peter; Macfarlan, Todd S.; Schumer, Molly; Tzika, Athanasia C.; Przeworski, Molly
作者单位：Columbia University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Stanford University; Columbia University; Howard Hughes Medical Institute; University of Geneva; Washington University (WUSTL); University of California System; University of California Davis; 23andMe, Inc.; University of Cambridge
摘要：In some mammals, notably humans, recombination occurs almost exclusively where the protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and canids, recombination rates are elevated near promoter-like features. To determine whether PRDM9 directs recombination in nonmammalian vertebrates, we focused on an exemplar species with a single, intact PRDM9 ortholog, the corn snake (Pantherophis guttatus). Analyzing historical recombination rates along the genome and crosso...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
