作者：Song, Wenhao; Rao, Mingyi; Li, Yunning; Li, Can; Zhuo, Ye; Cai, Fuxi; Wu, Mingche; Yin, Wenbo; Li, Zongze; Wei, Qiang; Lee, Sangsoo; Zhu, Hengfang; Gong, Lei; Barnell, Mark; Wu, Qing; Beerel, Peter A.; Chen, Mike Shuo-Wei; Ge, Ning; Hu, Miao; Xia, Qiangfei; Yang, J. Joshua
作者单位：University of Southern California; University of Massachusetts System; University of Massachusetts Amherst
摘要：In-memory computing represents an effective method for modeling complex physical systems that are typically challenging for conventional computing architectures but has been hindered by issues such as reading noise and writing variability that restrict scalability, accuracy, and precision in high-performance computations. We propose and demonstrate a circuit architecture and programming protocol that converts the analog computing result to digital at the last step and enables low-precision ana...
作者：Krishna, Chirag; Tervi, Anniina; Saffern, Miriam; Wilson, Eric A.; Yoo, Seong-Keun; Mars, Nina; Roudko, Vladimir; Cho, Byuri Angela; Jones, Samuel Edward; Vaninov, Natalie; Selvan, Myvizhi Esai; Gumus, Zeynep H.; Lenz, Tobias L.; Merad, Miriam; Boffetta, Paolo; Martinez-Jimenez, Francisco; Ollila, Hanna M.; Samstein, Robert M.; Chowell, Diego
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Helsinki; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Hamburg; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Bologna; State University of New York (SUNY) System; Stony Brook University; Vall d'Hebron Institut d'Oncologia (VHIO); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Icahn School of Medicine at Mount Sinai
摘要：Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in immunosurveillance on cancer risk is not well understood. Leveraging population-level data from the UK Biobank and FinnGen, we show that heterozygosity at the human leukocyte antigen (HLA)-II loci is associated with reduced lung cancer risk in smokers. Fine-mapping implicated amino acid heterozygosity in the HLA-II peptide binding groove in reduced...
作者：Irannezhad, Masoud; Sadeqi, Amin; Liu, Junguo; Chen, Deliang
作者单位：University of Oulu; University of Turku; North China University of Water Resources & Electric Power; University of Gothenburg
