6731期

最新文章

• Navigating the complexity of touch AI翻译
  作者：Marasco, Paul D.
  作者单位：Cleveland Clinic Foundation
• Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes AI翻译
  作者：Zhang, Xuchen; Chen, Xudong; Matus, Daniel; Sudhof, Thomas C.
  作者单位：Stanford University; Howard Hughes Medical Institute
  摘要：Synapses are organized by trans-synaptic adhesion molecules that coordinate assembly of pre- and postsynaptic specializations, which, in turn, are composed of scaffolding proteins forming liquid-liquid phase-separated condensates. Presynaptic teneurins mediate excitatory synapse organization by binding to postsynaptic latrophilins; however, the mechanism of action of teneurins, driven by extracellular domains evolutionarily derived from bacterial toxins, remains unclear. In this work, we show ...
• Deep drilling opens longest view of climate history AI翻译
  作者：Brainard, Jeffrey
• Australopithecus at Sterkfontein did not consume substantial mammalian meat AI翻译
  作者：Luedecke, Tina; Leichliter, Jennifer N.; Stratford, Dominic; Sigman, Daniel M.; Vonhof, Hubert; Haug, Gerald H.; Bamford, Marion K.; Martinez-Garcia, Alfredo
  作者单位：Max Planck Society; Max Planck Society; University of Witwatersrand; University of Witwatersrand; State University of New York (SUNY) System; Stony Brook University; Princeton University; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Incorporation of animal-based foods into early hominin diets has been hypothesized to be a major catalyst of many important evolutionary events, including brain expansion. However, direct evidence of the onset and evolution of animal resource consumption in hominins remains elusive. The nitrogen-15 to nitrogen-14 ratio of collagen provides trophic information about individuals in modern and geologically recent ecosystems (<200,000 years ago), but diagenetic loss of this organic matter preclude...
• Myostatin's flex on the reproductive hormone axis AI翻译
  作者：Steenwinkel, Tessa E.; Pangas, Stephanie A.
  作者单位：Baylor College of Medicine; Baylor College of Medicine
• A panoramic view of cell population dynamics in mammalian aging AI翻译
  作者：Zhang, Zehao; Schaefer, Chloe; Jiang, Weirong; Lu, Ziyu; Lee, Jasper; Sziraki, Andras; Abdulraouf, Abdulraouf; Wick, Brittney; Haeussler, Maximilian; Li, Zhuoyan; Molla, Gesmira; Satija, Rahul; Zhou, Wei; Cao, Junyue
  作者单位：Rockefeller University; Rockefeller University; University of California System; University of California Santa Cruz; New York University
  摘要：To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and org...
• African health fellowships debut AI翻译
  作者：Brainard, Jeffrey
• INFECTIOUS DISEASES Why the 'Ferrari of viruses' is surging AI翻译
  作者：Cohen, Jon
• BIOMEDICINE 'Safe harbor' gene therapy approach may have first success AI翻译
  作者：Kaiser, Jocelyn
• Don't pretend COVID-19 didn't happen AI翻译
  作者：Van Kerkhove, Maria D.
  作者单位：World Health Organization