A panoramic view of cell population dynamics in mammalian aging

• 成果类型: Article
• 署名作者: Zhang, Zehao; Schaefer, Chloe; Jiang, Weirong; Lu, Ziyu; Lee, Jasper; Sziraki, Andras; Abdulraouf, Abdulraouf; Wick, Brittney; Haeussler, Maximilian; Li, Zhuoyan; Molla, Gesmira; Satija, Rahul; Zhou, Wei; Cao, Junyue
• 署名单位: Rockefeller University; Rockefeller University; University of California System; University of California Santa Cruz; New York University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11976
• DOI: 10.1126/science.adn3949
• 发表日期: 2025-01-17
• 页码: 262-+
• 关键词: atlas; mice; healthy

摘要

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our cell-omics strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.