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作者：Jackson, Christina; Cherry, Christopher; Bom, Sadhana; Dykema, Arbor G.; Wang, Rulin; Thompson, Elizabeth; Zhang, Ming; Li, Runzhe; Ji, Zhicheng; Hou, Wenpin; Zhan, Wentao; Zhang, Hao; Choi, John; Vaghasia, Ajay; Hansen, Landon; Wang, William; Bergsneider, Brandon; Jones, Kate M.; Rodriguez, Fausto; Weingart, Jon; Lucas, Calixto-Hope; Powell, Jonathan; Elisseeff, Jennifer; Yegnasubramanian, Srinivasan; Lim, Michael; Bettegowda, Chetan; Ji, Hongkai; Pardoll, Drew
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Medicine; Stanford University; Stanford Medicine; Johns Hopkins University; Johns Hopkins Medicine
摘要：The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two distinct myeloid-derived suppressor cell (MDSC) populations in isocitrate dehydrogenase-wild-type (IDT-WT) glioblastoma: an early progenitor MDSC (E-MDSC) population with up-regulation of metabolic and hypoxia pathways and a monocytic MDSC (M-MDSC) population. Spatial transcriptomics demonstr...
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作者：Naegele, Kathrin
作者单位：Max Planck Society
摘要：Narratives that invoke ancient DNA must be crafted with care, argues an archaeologist
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作者：Brainard, Jeffrey
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作者：Ferrante, Lucas
作者单位：Universidade de Sao Paulo; Universidade Federal de Amazonas
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作者：Sestan, Marko -; Raposo, Bruno; Rendas, Miguel; Brea, David; Pirzgalska, Roksana; Rasteiro, Ana; Aliseychik, Maria; Godinho, Ines; Ribeiro, Helder; Carvalho, Tania; Wueest, Stephan; Konrad, Daniel; Veiga-Fernandes, Henrique
作者单位：University of Rijeka; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas de Barcelona (IIBB); University Children's Hospital Zurich; University of Zurich; University of Zurich; University Children's Hospital Zurich; University of Zurich; Zurich Center Integrative Human Physiology (ZIHP)
摘要：The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions orchestrate endocrine system functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid cells (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, and inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the panc...
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作者：Wadman, Meredith
摘要：Climate change may be driving an expansion of Valley fever, a deadly fungal infection spread by airborne spores
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作者：Bardot, Madison I.; Weyhrich, Cody W.; Shi, Zixiao; Traxler, Michael; Stern, Charlotte L.; Cui, Jinlei; Muller, David A.; Becker, Matthew L.; Dichtel, William R.
作者单位：Northwestern University; Duke University; Cornell University; Cornell University; Cornell University; Duke University; Duke University
摘要：Mechanical bonds arise between molecules that contain interlocked subunits, such as one macrocycle threaded through another. Within polymers, these linkages will confer distinctive mechanical properties and other emergent behaviors, but polymerizations that form mechanical bonds efficiently and use simple monomeric building blocks are rare. In this work, we introduce a solid-state polymerization in which one monomer infiltrates crystals of another to form a macrocycle and mechanical bond at ea...
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作者：Pande, Rohini
作者单位：Yale University
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作者：Zhou, Wenjie; Nadarajah, Sujeeka; Li, Liuchi; Izard, Anna Guell; Yan, Hujie; Prachet, Aashutosh K.; Patel, Payal; Xia, Xiaoxing; Daraio, Chiara
作者单位：California Institute of Technology; Princeton University; Johns Hopkins University; United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：Architected materials derive their properties from the geometric arrangement of their internal structural elements. Their designs rely on continuous networks of members to control the global mechanical behavior of the bulk. In this study, we introduce a class of materials that consist of discrete concatenated rings or cage particles interlocked in three-dimensional networks, forming polycatenated architected materials (PAMs). We propose a general design framework that translates arbitrary crys...
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作者：He, Yifan; Czaplicki Cabezas, Stasiek; Maillard, Oswaldo; Mueller, Robert; Romero-Munoz, Alfredo; Romero Pimentel, Laurenz Feliciano; Vadillo, Alcides; Vos, Vincent Antoine
作者单位：University of California System; University of California Santa Barbara; Humboldt University of Berlin
