6733期

最新文章

• Randomizing the human genome by engineering recombination between repeat elements AI翻译
  作者：Koeppel, Jonas; Ferreira, Raphael; Vanderstichele, Thomas; Riedmayr, Lisa Maria; Peets, Elin Madli; Girling, Gareth; Weller, Juliane; Murat, Pierre; Liberante, Fabio Giuseppe; Ellis, Tom; Church, George McDonald; Parts, Leopold
  作者单位：Wellcome Trust Sanger Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Imperial College London; Harvard University; Harvard Medical School
  摘要：We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which enables generating large-scale deletions, inversions, translocations, and circular DNA. Recombinase induction produced more than 100 stochastic megabase-sized rearrangements in each cell. We tracked these rearrangements over time to measure selec...
• Learning the language of life with AI AI翻译
  作者：Topol, Eric J.
  作者单位：Scripps Research Institute
• Rising seas endanger maritime heritage AI翻译
  作者：Erlandson, Jon M.; Fitzpatrick, Scott M.; Gill, Kristina M.; Kirch, Patrick V.; Ruiz, John T.; Thompson, Victor D.; Younker, Jason
  作者单位：University of Oregon; University of Oregon; University of Hawaii System; University of Hawaii Manoa; University System of Georgia; University of Georgia
• Irregular mowing helps insects AI翻译
  作者：Brainard, Jeffrey
• Ancient genomics and the origin, dispersal, and development of domestic sheep AI翻译
  作者：Daly, Kevin G.; Mullin, Victoria E.; Hare, Andrew J.; Halpin, Aine; Mattiangeli, Valeria; Teasdale, Matthew D.; Rossi, Conor; Geiger, Sheila; Krebs, Stefan; Medugorac, Ivica; Sandoval-Castellanos, Edson; Ozbasaran, Mihriban; Duru, Gunes; Gulcur, Sevil; Poellath, Nadja; Collins, Matthew; Frantz, Laurent; Vila, Emmanuelle; Zidarov, Peter; Stoddart, Simon; Boldgiv, Bazartseren; Orlando, Ludovic; Pearson, Mike Parker; Mullville, Jacqui; Askeyev, Igor V.; Askeyev, Arthur O.; Askeyev, Oleg V.; Shaymuratova, Dilyara N.; Van den Hurk, Youri; Zeeb-Lanz, Andrea; Arbogast, Rose-Marie; Hemmer, Helmut; Davoudi, Hossein; Amiri, Sarieh; Doost, Sanaz Beizaee; Decruyenaere, Delphine; Fathi, Homa; Khazaeli, Roya; Hassanzadeh, Yousef; Sardari, Alireza; Lhuillier, Johanna; Abdolahi, Mostafa; Summers, Geoffrey D.; Marro, Catherine; Bahshaliyev, Veli; Berthon, Remi; Cakirlar, Canan; Benecke, Norbert; Scheu, Amelie; Burger, Joachim; Sauer, Eberhard; Horwitz, Liora Kolska; Arbuckle, Benjamin; Buitenhuis, Hijlke; Gourichon, Lionel; Bulatovic, Jelena; O'Connor, Terry; Orton, David; Jalabadze, Mindia; Rhodes, Stephen; Chazan, Michael; Ozkaya, Vecihi; Zeder, Melinda; Atici, Levent; Mashkour, Marjan; Peters, Joris; Bradley, Daniel G.
  作者单位：Trinity College Dublin; University College Dublin; Newcastle University - UK; University of Munich; University of Munich; University of Munich; University of Munich; Istanbul University; Mimar Sinan Guzel Sanatlar University; University of Copenhagen; University of Cambridge; University of London; Queen Mary University London; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Lyon 2; Eberhard Karls University of Tubingen; University of Cambridge; National University of Mongolia; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of London; University College London; Cardiff University; University of Groningen; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); University of Tehran; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Islamic Azad University; Nantes Universite; Azerbaijan National Academy of Sciences (ANAS); Johannes Gutenberg University of Mainz; University of Edinburgh; Hebrew University of Jerusalem; University of North Carolina; University of North Carolina Chapel Hill; Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); University of Gothenburg; University of York - UK; University of Toronto; University of Witwatersrand; Dicle University; Smithsonian Institution; North Carolina State University
  摘要：The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this, we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central Turkiye similar to 8000 BCE are genetically proximal to the domestic origins of sheep but do not fully explain the ancestry of later populations, suggesting a mosaic of wild ancestries. Genomic signatures indicate selection by ancient herders for pigmentation patterns, hornednes...
• Genome recombination on demand AI翻译
  作者：Seczynska, Marta; Steinmetz, Lars M.
  作者单位：Stanford University; Stanford University; European Molecular Biology Laboratory (EMBL)
• Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation AI翻译
  作者：Liu, Andrew W.; Zhang, Youran R.; Chen, Chien-Sin; Edwards, Tara N.; Ozyaman, Sumeyye; Ramcke, Torben; McKendrick, Lindsay M.; Weiss, Eric S.; Gillis, Jacob E.; Laughlin, Colin R.; Randhawa, Simran K.; Phelps, Catherine M.; Kurihara, Kazuo; Kang, Hannah M.; Nguyen, Sydney-Lam N.; Kim, Jiwon; Sheahan, Tayler D.; Ross, Sarah E.; Meisel, Marlies; Sumpter, Tina L.; Kaplan, Daniel H.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Istanbul Medipol University; Yale University; Medical College of Wisconsin
  摘要：Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and whether scratching provides benefit to the host are largely unknown. We found that scratching was required for skin inflammation in mouse models dependent on Fc epsilon RI-mediated mast cell activation. Scratching-induced inflammation required pain-sensing nociceptors, the neuropeptide substance P, and...
• Trump gender order upends federal surveys AI翻译
  作者：Mervis, Jeffrey
  摘要：Move would ban data collection on transgender and nonbinary people
• Invoking Asilomar The historic meeting's legacy resists simple lessons AI翻译
  作者：Campos, Luis A.
  作者单位：Rice University; Rice University
• Hippocampal coding of identity, sex, hierarchy, and affiliation in a social group of wild fruit bats AI翻译
  作者：Ray, Saikat; Yona, Itay; Elami, Nadav; Palgi, Shaked; Latimer, Kenneth W.; Jacobsen, Bente; Witter, Menno P.; Las, Liora; Ulanovsky, Nachum
  作者单位：Weizmann Institute of Science; University of Chicago; Norwegian University of Science & Technology (NTNU)
  摘要：Social animals live in groups and interact volitionally in complex ways. However, little is known about neural responses under such natural conditions. Here, we investigated hippocampal CA1 neurons in a mixed-sex group of five to 10 freely behaving wild Egyptian fruit bats that lived continuously in a laboratory-based cave and formed a stable social network. In-flight, most hippocampal place cells were socially modulated and represented the identity and sex of conspecifics. Upon social interac...