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作者：[Anonymous]
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作者：Brainard, Jeffrey
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作者：Hurlbut, J. Benjamin
作者单位：Arizona State University; Arizona State University-Tempe
摘要：In February 1975, leading molecular biologists gathered at the Asilomar conference center on the California coast to evaluate risks of the emerging technology of recombinant DNA and to establish guidelines to govern research. The meeting is remembered as a defining moment in the making of molecular biology. Yet its legacy lies not in specific rules it developed but in the approach to scientific self-regulation that it crystallized. Five decades later, this near-mythic meeting that changed the ...
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作者：Parthasarathy, Shobita
作者单位：University of Michigan System; University of Michigan
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作者：Jhala, Yadvendradev V.; Mungi, Ninad Avinash; Gopal, Rajesh; Qureshi, Qamar
作者单位：Wildlife Institute of India; Aarhus University; National Tiger Conservation Authority, Government of India; Indian National Science Academy (INSA); Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS)
摘要：Recovery of large yet ecologically important carnivores poses a formidable global challenge. Tiger (Panthera tigris) recovery in India, the world's most populated region, offers a distinct opportunity to evaluate the socio-ecological drivers of megafauna recovery. Tiger occupancy increased by 30% (at 2929 square kilometers per year) over the past two decades, leading to the largest global population occupying similar to 138,200 square kilometers. Tigers persistently occupied human-free, prey-r...
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作者：Kemp, R. Scott; Lyman, Edwin S.; Deinert, Mark R.; Garwin, Richard L.; von Hippel, Frank N.
作者单位：Massachusetts Institute of Technology (MIT); Colorado School of Mines; International Business Machines (IBM); IBM USA; Princeton University
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作者：Mallory, Caitlin S.; Widloski, John; Foster, David J.
作者单位：University of California System; University of California Berkeley
摘要：The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content is strictly organized over multiple timescales and governed by self-avoidance. After movement cessation, replays avoided the animal's previous path for 3 seconds. Chains of replays avoided self-repetition over a shorter timescale. We used a continuous attractor model of neural activity to demonstra...
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作者：Markert, Jonathan W.; Soffers, Jelly H.; Farnung, Lucas
作者单位：Harvard University; Harvard Medical School; University of Missouri System; University of Missouri Kansas City
摘要：During transcription, RNA polymerase II traverses through chromatin, and posttranslational modifications including histone methylations mark regions of active transcription. Histone protein H3 lysine 36 trimethylation (H3K36me3), which is established by the histone methyltransferase SET domain containing 2 (SETD2), suppresses cryptic transcription, regulates splicing, and serves as a binding site for transcription elongation factors. The mechanism by which the transcription machinery coordinat...
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作者：Marshall, Lisa
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作者：Pinglay, Sudarshan; Lalanne, Jean-Benoit; Daza, Riza M.; Kottapalli, Sanjay; Quaisar, Faaiz; Koeppel, Jonas; Garge, Riddhiman K.; Li, Xiaoyi; Lee, David S.; Shendure, Jay
作者单位：University of Washington; University of Washington Seattle; Wellcome Trust Sanger Institute; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) methods to generate, map, and characterize SVs in model systems are underdeveloped. To address these challenges, we developed Genome-Shuffle-seq, a method that enables the multiplex generation and mapping of thousands of SVs (deletions, inversions, translocations, and extrachromosomal circles) thr...
