6733期

最新文章

• Pre-exposure antibody prophylaxis protects macaques from severe influenza AI翻译
  作者：Kanekiyo, Masaru; Gillespie, Rebecca A.; Cooper, Kristine; Canedo, Vanessa Guerra; Castanha, Priscila M. S.; Pegu, Amarendra; Yang, Eun Sung; Treaster, Luke; Yun, Gabin; Wallace, Megan; Kettenburg, Gwenddolen; Williams, Connor; Lundy, Jeneveve; Barrick, Stacey; O'Malley, Katherine; Midgett, Morgan; Marti, Michelle M.; Chavva, Hasitha; Corry, Jacqueline; Treat, Benjamin R.; Lipinski, Abby; Batsche, Lucia Ortiz; Creanga, Adrian; Ritter, Isabella; Walker, Reagan; Olsen, Emily; Laughlin, Amanda; Perez, Daniel R.; Mascola, John R.; Boritz, Eli A.; Loo, Yueh-Ming; Blair, Wade; Esser, Mark; Graham, Barney S.; Reed, Douglas S.; Barratt-Boyes, Simon M.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; AstraZeneca; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Chicago; University System of Ohio; Ohio State University; St Jude Children's Research Hospital; Baylor College of Medicine; Emory University; Tulane University; University of Hawaii System; Morehouse School of Medicine
  摘要：Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasures. In this study, we show that pre-exposure prophylaxis with broadly neutralizing antibody (bnAb) MEDI8852 is highly effective in protecting cynomolgus macaques from severe disease caused by aerosolized highly pathogenic avian influenza H5N1 virus infection. Protection was antibody dose-dependen...
• Replaying off the beaten path AI翻译
  作者：Takigawa, Masahiro; Bendor, Daniel
  作者单位：University of London; University College London
• Climate deja vu AI翻译
  作者：Thorp, H. Holden
• Addressing interconnect challenges for enhanced computing performance (vol 386, eadk6189, 2024) AI翻译
  作者：[Anonymous]
• Laser-powered accelerators, compact and cheap, get real AI翻译
  作者：Cho, Adrian
  摘要：Encouraging lab results bolster plans to harness a new kind of particle accelerator in x-ray sources
• Conformational dynamics of a multienzyme complex in anaerobic carbon fixation AI翻译
  作者：Yin, Max Dongsheng; Lemaire, Olivier N.; Jimenez, Jose Guadalupe Rosas; Belhamri, Melissa; Shevchenko, Anna; Hummer, Gerhard; Wagner, Tristan; Murphy, Bonnie J.
  作者单位：Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS)
  摘要：In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO2) is fixed in a multistep process that ends with acetyl-coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In this work, we present structural snapshots of the CODH/ACS from the gas-converting acetogen Clostridium autoethanogenum, characterizing the molecular choreography of the overall reaction, including electron transfer to the CODH for CO2 reduction, ...
• In India, a debate over the benefits of gas stoves AI翻译
  作者：Chandrashekhar, Vaishnavi
  摘要：Surprise finding of few health payoffs complicates push to replace biomass fuel
• Global study shows species are losing diversity AI翻译
  作者：Pennisi, Elizabeth
  摘要：Even in some common species, the genetic variation key to resilience is slipping away
• Banished from CERN, Russian physicists regroup AI翻译
  作者：[Anonymous]
  摘要：Breakdown in collaboration leads many scientists to look to domestic projects-and to China
• TIR signaling activates caspase-like immunity in bacteria AI翻译
  作者：Rousset, Francois; Osterman, Ilya; Scherf, Tali; Falkovich, Alla H.; Leavitt, Azita; Amitai, Gil; Shir, Sapir; Malitsky, Sergey; Itkin, Maxim; Savidor, Alon; Sorek, Rotem
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Ecole Normale Superieure de Lyon (ENS de LYON)
  摘要：Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5-diphosphate-cyclo[N7:1 '']-ribose (N7-cADPR). This molecule specifically activates the bacterial caspase-...