6752期

最新文章

• Warming threatens fragile pact over Indus River waters AI翻译
  作者：Pathak, Sushmita
• An American research crisis with real human consequences AI翻译
  作者：Parlange, Marc B.
  作者单位：University of Rhode Island
• A liability framework for high-risk neural devices AI翻译
  作者：Rotenberg, A.; Gunning, M.; Nadler, R. Magistro; Kiss, Z. H. T.; Illes, J.
  作者单位：University of British Columbia; University of British Columbia; University of British Columbia; University of Calgary
• Plant microbiomes feel the heat AI翻译
  作者：Laine, Anna-Liisa; Leino, Sara
  作者单位：University of Helsinki
• Strangling intellectual independence AI翻译
  作者：Harris, Michael S.
  作者单位：Southern Methodist University
• Trump budget proposes killing nursing research institute AI翻译
  作者：Wadman, Meredith
• Safeguarding crop photosynthesis in a rapidly warming world AI翻译
  作者：Bernacchi, Carl J.; Long, Stephen P.; Ort, Donald R.
  作者单位：United States Department of Agriculture (USDA); University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Continued greenhouse gas emissions will accelerate global warming and intensity of heat waves, which already harm crop productivity. From the stability of key enzymes to canopy processes, photosynthesis is affected by temperature. All crops suffer declines in photosynthetic rate when temperatures cross critical thresholds, with irreversible losses typically occurring above 40 degrees to 45 degrees C. Protective measures within plants can be induced by growth at elevated temperatures but not fr...
• Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation AI翻译
  作者：Blumer, L. M.; Burskaia, V.; Artiushin, I.; Saha, J.; Garcia, J. Camacho; Jimenez, F. Campuzano; Hooft van der Huysdynen, A.; Elkin, J.; Fischer, B.; Van Houtte, N.; Zhou, C.; Gresham, S.; Malinsky, M.; Linderoth, T.; Sawasawa, W.; Vernaz, G.; Bista, I.; Hickey, A.; Kucka, M.; Louzada, S.; Zatha, R.; Yang, F.; Rusuwa, B.; Santos, M. E.; Chan, Y. F.; Joyce, D. A.; Boehne, A.; Miska, E. A.; Ngochera, M.; Turner, G. F.; Durbin, R.; Svardal, H.
  作者单位：University of Cambridge; University of Antwerp; University of Cambridge; Wellcome Trust Sanger Institute; University of Bern; Michigan State University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Max Planck Society; Eberhard Karls University of Tubingen; University of Malawi; Shandong University of Technology; University of Groningen; University of Hull; University of Cambridge; Bangor University; Naturalis Biodiversity Center; University of Basel; University of Cologne; University of Tras-os-Montes & Alto Douro; BIOISI; Universidade de Lisboa
  摘要：Chromosomal inversions can contribute to adaptive speciation by linking coadapted alleles. By querying 1375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large inversions segregating in the benthic subradiation that each suppress recombination over more than half a chromosome. Two inversions were transferred from deepwater pelagic Diplotaxodon through admixture, whereas the others established early in the deep benthic clade. Introgression of haplotypes from line...
• Aberrant basal cell clonal dynamics shape early lung carcinogenesis AI翻译
  作者：Gomez-Lopez, Sandra; Alhendi, Ahmed S. N.; Przybilla, Moritz J.; Bordeu, Ignacio; Whiteman, Zoe E.; Butler, Timothy; Rouhani, Maral J.; Kalinke, Lukas; Uddin, Imran; Otter, Kate E. J.; Chandrasekharan, Deepak P.; Lebrusant-Fernandez, Marta; Shurr, Abigail Y. L.; Durrenberger, Pascal F.; Moore, David A.; Falzon, Mary; Reading, James L.; Martincorena, Inigo; Simons, Benjamin D.; Campbell, Peter J.; Janes, Sam M.
  作者单位：University of London; University College London; Wellcome Trust Sanger Institute; Universidad de Chile; University of London; University College London; University of London; University College London; University of London; University College London; Cancer Research UK; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; University College London; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of London; University College London; University College London Hospitals NHS Foundation Trust
  摘要：Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we found that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions developed from a few highly mutated clones that dominate most of the...
• Rethinking jaundice A buildup of unconjugated bilirubin may be a protective response to malaria AI翻译
  作者：Kloehn, Joachim; Soldati-Favre, Dominique
  作者单位：University of Geneva