Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation

• 成果类型: Article
• 署名作者: Blumer, L. M.; Burskaia, V.; Artiushin, I.; Saha, J.; Garcia, J. Camacho; Jimenez, F. Campuzano; Hooft van der Huysdynen, A.; Elkin, J.; Fischer, B.; Van Houtte, N.; Zhou, C.; Gresham, S.; Malinsky, M.; Linderoth, T.; Sawasawa, W.; Vernaz, G.; Bista, I.; Hickey, A.; Kucka, M.; Louzada, S.; Zatha, R.; Yang, F.; Rusuwa, B.; Santos, M. E.; Chan, Y. F.; Joyce, D. A.; Boehne, A.; Miska, E. A.; Ngochera, M.; Turner, G. F.; Durbin, R.; Svardal, H.
• 署名单位: University of Cambridge; University of Antwerp; University of Cambridge; Wellcome Trust Sanger Institute; University of Bern; Michigan State University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Max Planck Society; Eberhard Karls University of Tubingen; University of Malawi; Shandong University of Technology; University of Groningen; University of Hull; University of Cambridge; Bangor University; Naturalis Biodiversity Center; University of Basel; University of Cologne; University of Tras-os-Montes & Alto Douro; BIOISI; Universidade de Lisboa
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13562
• DOI: 10.1126/science.adr9961
• 发表日期: 2025-06-12
• 关键词: local adaptation; reproductive isolation; genomic basis; EVOLUTION; diversification; recombination; speciation; selection

摘要

Chromosomal inversions can contribute to adaptive speciation by linking coadapted alleles. By querying 1375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large inversions segregating in the benthic subradiation that each suppress recombination over more than half a chromosome. Two inversions were transferred from deepwater pelagic Diplotaxodon through admixture, whereas the others established early in the deep benthic clade. Introgression of haplotypes from lineages inside and outside the Malawi radiation coincided with bursts of species diversification. Inversions show evidence for transient sex linkage, and a notable excess of protein changing substitutions points toward selection on neurosensory, physiological, and reproductive genes. These results indicate that repeated interplay between depth adaptation and sex-specific selection on large inversions has been central to the evolution of this iconic system.