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作者:Gilette, Nicole M.; Lipton, Jonathan O.
作者单位:Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School
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作者:Sinnott-Armstrong, Nasa; Forsythe, Desiree; Benoit, Jane M.; Chappell, Callie R.; Coe, Lisa S. Y.; de Oliveira, Bruno Francesco Rodrigues; Evans, Natalya; Fagre, Anna C.; Gilligan, Jonathan M.; Hamilton, Maria; Henneberry, Colin Moran; Ishaq, Suzanne L.; Johnston, Juliet; Krichilsky, Erin; Lopez, Jamie Alcira; McMonigal, Kay; de la Campa, Melanie Ortiz Alvarez; Rahman, Rahmeen; Schwartz, Nicole E.; Talluto, Lauren; Taylor, Eric J.; Vargas-Muniz, Jose M.; Weissman, J. L.
作者单位:Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Santa Clara University; State University System of Florida; Florida State University; Stanford University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Universidade Federal Fluminense; University of California System; University of California Santa Barbara; Colorado State University System; Colorado State University Fort Collins; Vanderbilt University; Vanderbilt University; University System of Georgia; University of Georgia; State University of New York (SUNY) System; Stony Brook University; University of Maine System; University of Maine Orono; Columbia University; Stanford University; Stanford University; University of Alaska System; University of Alaska Fairbanks; Brown University; Imperial College London; Chapman University System; Chapman University; University of Innsbruck; University of Arizona; Virginia Polytechnic Institute & State University; State University of New York (SUNY) System; Stony Brook University
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作者:Allen, Karen; Armentrout, Peter B.; Berkman, Clifford; Boxer, Steven G.; Burkart, Michael; Canary, James W.; Castellano, Ronald K.; Columbus, Linda; DeRose, Victoria J.; Fairbrother, Howard; Ferguson, Gregory S.; Foley, Joe; Haynes, Christy; Heemstra, Jennifer M.; Jaekle, Frieder; Knappenberger, Kenneth; Kong, Wei; Kaufman, Laura J.; Lambert, Tristan H.; Lin, Yu-Shan; Liu, Haitao; Metz, Ricardo; Morris, Amanda; Murphy, Catherine J.; Peczuh, Mark; Pennington, William; Pojman, John A.; Reisman, Sarah; Shores, Matthew; Spokoyny, Alexander M.; Szulczewski, Greg; Van Voorhis, Troy; Warren, Timothy H.; Wang, Lai-Sheng; Wysocki, Vicki; Zhang, Jin
作者单位:Boston University; Utah System of Higher Education; University of Utah; Washington State University; Stanford University; University of California System; University of California San Diego; New York University; State University System of Florida; University of Florida; University of Virginia; University of Oregon; Johns Hopkins University; Lehigh University; Drexel University; University of Minnesota System; University of Minnesota Twin Cities; Washington University (WUSTL); Rutgers University System; Rutgers University Newark; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Oregon State University; Columbia University; Cornell University; Tufts University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Massachusetts System; University of Massachusetts Amherst; Virginia Polytechnic Institute & State University; University of Illinois System; University of Illinois Urbana-Champaign; University of Connecticut; Clemson University; Louisiana State University System; Louisiana State University; California Institute of Technology; Colorado State University System; Colorado State University Fort Collins; University of California System; University of California Los Angeles; University of Alabama System; University of Alabama Tuscaloosa; Massachusetts Institute of Technology (MIT); Michigan State University; Brown University; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Santa Cruz
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作者:Brown, Taylor Mitchell; Hersher, Monica
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作者:Clery, Daniel
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作者:Michaels, David; Wagner, Wendy
作者单位:George Washington University; University of Texas System; University of Texas Austin
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作者:Aleksandrova, Elena V.; Syroegin, Egor A.; Basu, Ritwika S.; Vassilevski, Alexander A.; Gagnon, Matthieu G.; Polikanov, Yury S.
作者单位:University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Texas System; University of Texas Medical Branch Galveston; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要:Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factors (RFs) that recognize stop codons and catalyze the hydrolysis of peptidyl transfer RNA (peptidyl-tRNA) on the ribosome, presumably by activating a water molecule. We report structures of the bacterial ribosome in complex with peptidyl-tRNA and RFs in the prepeptide release state. No hydrolytic wa...
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作者:Bains, Amreen K.; Sau, Arindam; Portela, Brandon S.; Kajal, Kajal; Green, Alexander R.; Wolff, Anna M.; Patin, Ludovic F.; Paton, Robert S.; Damrauer, Niels H.; Miyake, Garret M.
作者单位:Colorado State University System; Colorado State University Fort Collins; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要:Photoredox catalysis driven by visible light has improved chemical synthesis by enabling milder reaction conditions and unlocking distinct reaction mechanisms. Despite the transformative impact, visible-light photoredox catalysis remains constrained by the thermodynamic limits of photon energy and inefficiencies arising from unproductive back electron transfer, both of which become particularly pronounced in thermodynamically demanding reactions. In this work, we introduce an organic photoredo...
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作者:Thompson, Valerie
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作者:Espey, Jessica M.; Tatem, Andrew J.; Thomson, Dana R.
作者单位:University of Southampton; Columbia University