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作者：Eroglu, C.
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作者：Bub, Sascha; Petschick, Lara L.; Stehle, Sebastian; Wolfram, Jakob; Schulz, Ralf
摘要：Macroscale evaluations of chemical monitoring data require the integration of chemical, spatial, and temporal dimensions. Here, we linked 64 million US surface water monitoring records (1900 chemicals, date range 1958 to 2019, 310,000 sites) and 37 million analytical limits and in vivo and in silico toxicity thresholds. We found that the exposure data required for retrospective risk assessment were available for less than 1% of chemicals with potential environmental concern (n approximate to 2...
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作者：Hunter, Theresa L.; Bao, Yanjie; Zhang, Yan; Matsuda, Daiki; Riener, Romina; Wang, Annabel; Li, John J.; Soldevila, Ferran; Chu, David S. H.; Nguyen, Duy P.; Yong, Qian-Chen; Ross, Brittany; Nguyen, Michelle; Vestal, James; Roberts, Scott; Galvan, Diana; Vega, Jerel Boyd; Jhung, Donald; Butcher, Matthew; Nguyen, Josephine; Zhang, Stanley; Fernandez, Claudia; Chen, Jeffrey; Herrera, Carolina; Kuo, Yi; Pica, E. Michael; Mondal, Goutam; Mammen, Andrew L.; Scholler, John; Tanis, Steven P.; Sievers, Stuart A.; Frantz, Aric M.; Adams, Gregor B.; Shawver, Laura; Farzaneh-Far, Ramin; Rosenzweig, Michael; Karmali, Priya P.; Bot, Adrian I.; June, Carl H.; Aghajanian, Haig
作者单位：National Institutes of Health (NIH) - USA; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restricting patient accessibility. We present an in vivo engineering strategy using targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets. These tLNPs reprogrammed CD8(+) T cells in both healthy donor and autoimmune patient samp...
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作者：Kirby, Georgina
作者单位：University of Gottingen
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作者：Kudela, Raphael M.
作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz
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作者：Charles, Dan
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作者：Song, Xin-Yi; Xia, Yushan; Zhang, Jun-Tao; Liu, Yu-Jun; Qi, Hua; Wei, Xin-Yang; Hu, Hailiang; Xia, Yu; Liu, Xue; Ma, Ying-Fei; Jia, Ning
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Shenzhen University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Southern University of Science & Technology; Southern University of Science & Technology
摘要：Prokaryotic defense-associated reverse transcriptases (DRTs) were recently identified with antiviral functions; however, their functional mechanisms remain largely unexplored. Here we show that DRT9 forms a hexameric complex with its upstream noncoding RNA (ncRNA) to mediate antiphage defense by inducing cell growth arrest through abortive infection. Upon phage infection, the phage-encoded ribonucleotide reductase NrdAB complex increases intracellular deoxyadenosine triphosphate levels, activa...
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作者：Clery, Daniel
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作者：Chen, Fu
作者单位：Hohai University
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作者：Large, Christopher R. L.; Khanal, Rupa; Hillier, LaDeana; Huynh, Chau; Kubo, Connor; Kim, Junhyong; Waterston, Robert H.; Murray, John I.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Washington; University of Washington Seattle
摘要：The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous cells. The conserved invariant embryonic lineage of Caenorhabditis elegans and C. briggsae makes them ideal for comparing cell type gene expression across evolution. Measuring the spatiotemporal divergence of gene expression across embryogenesis, we find a high level of similarity in gene expressi...
