作者：Kirby, Georgina
作者单位：University of Gottingen
作者：Lee, Sang Soo; Liu, Qiang; Cheng, Alexandra H. R.; Kim, Dong Won; Boudreau, Daphne M.; Mehta, Anuradha; Keles, Mehmet F.; Fejfer, Rafal; Palmer, Isabelle; Park, Kristen H.; Muenzberg, Heike; Harris, Timothy D.; Graves, Austin R.; Blackshaw, Seth; Wu, Mark N.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; Howard Hughes Medical Institute; Johns Hopkins University; Aarhus University
摘要：Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of thalamic nucleus reuniens (RE) neurons activated during sleep deprivation (SD) and required for sleep homeostasis. Optogenetic activation of RE neurons leads to an unusual phenotype: presleep behaviors (grooming and nest organizing) followed by prolonged, intense sleep that resembles RS. Inhibiting ...
作者：Peche, Vivek; Gottschalk, Stephen
作者单位：St Jude Children's Research Hospital
作者：Shi, Fu-Dong; Yong, V. Wee
作者单位：Capital Medical University; Tianjin Medical University; University of Calgary; University of Calgary
摘要：The brain's response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the flame of the brain. Although details differ and matter, neuroinflammation exacerbating neurodegeneration has similarities across multiple sclerosis and other neurological disorders, such as stroke and neurodegenerative diseases. Thus, lessons from successful disease-modifying therapies in multiple sclerosis may provide insights into strate...
作者：Michaels, David; Wagner, Wendy
作者单位：George Washington University; University of Texas System; University of Texas Austin
