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作者：Charles, Dan
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作者：Servick, Kelly
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作者：Bishop, Janice L.; Lane, Melissa D.
作者单位：SETI Institute
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作者：Cook, Annan S. I.; Chen, Minghao; Nguyen, Thanh N.; Cabezudo, Ainara Claveras; Khuu, Grace; Rao, Shanlin; Garcia, Samantha N.; Yang, Mingxuan; Iavarone, Anthony T.; Ren, Xuefeng; Lazarou, Michael; Hummer, Gerhard; Hurley, James H.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Walter & Eliza Hall Institute; University of Melbourne; Monash University; Max Planck Society; Max Planck Society; Goethe University Frankfurt; University of California System; University of California Berkeley
摘要：The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and PI3KC3-C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzyme activation through cryo-electron microscopy analysis of PI3KC3-C1. The inactive conformation of the VPS15 pseudokinase stabilizes the inactive conformation, sequestering its N-myristate in the N-lobe of the pseudokinase. Upon activation, the myristate is liberated such that the VPS34 lipi...
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作者：Jobin, Katarzyna; Seetharama, Deeksha; Ruettger, Lennart; Fenton, Chloe; Kharybina, Ekaterina; Wirsching, Annerose; Huang, Anfei; Knoepper, Konrad; Kaisho, Tsuneyasu; Busch, Dirk H.; Vaeth, Martin; Saliba, Antoine-Emmanuel; Graw, Frederik; Pulfer, Alain; Gonzalez, Santiago F.; Zehn, Dietmar; Liang, Yinming; Ugur, Milas; Gasteiger, Georg; Kastenmueller, Wolfgang
作者单位：University of Wurzburg; Max Planck Society; Wakayama Medical University; Technical University of Munich; Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Universita della Svizzera Italiana; Technical University of Munich; Henan Medical University
摘要：T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed their migration has been unclear. We identified a distinct priming phase that favors CD8 T cells expressing receptors with high affinity for antigen. CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs i...
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作者：Li, Xuan; Fu, Qizi; Wang, Qilin
作者单位：University of Technology Sydney
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作者：Servick, Kelly
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作者：Midavaine, Elora; Moraes, Beatriz C.; Benitez, Jorge; Rodriguez, Sian R.; Braz, Joao M.; Kochhar, Nathan P.; Eckalbar, Walter L.; Tian, Lin; Domingos, Ana I.; Pintar, John E.; Basbaum, Allan I.; Kashem, Sakeen W.
作者单位：University of California System; University of California San Francisco; Max Planck Society; University of Oxford; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA)
摘要：T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (T-reg cells) could inhibit nociception through a mechanism that was not dependent on their ability to regulate immune activation and tissue repair. Site-specific depletion or expansion of meningeal T-reg cells (mT(reg) cells) in mice led to female-specific and sex hormone-dependent modulation of mechanical sensitivity. Specific...
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作者：Servais, Bram
作者单位：University of Melbourne
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作者：Zhang, Hao
作者单位：Massachusetts Institute of Technology (MIT)
