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作者：Zheng, Yu; Cai, Ruyi; Wang, Kui; Zhang, Junwei; Zhuo, Yizhou; Dong, Hui; Zhang, Yuqi; Wang, Yifan; Deng, Fei; Ji, En; Cui, Yiwen; Fang, Shilin; Zhang, Xinxin; Huang, Haiyun; Zhang, Kecheng; Wang, Jinxu; Li, Guochuan; Miao, Xiaolei; Wang, Zhenghua; Yang, Yuqing; Li, Shaochuang; Grimm, Jonathan B.; Johnsson, Kai; Schreiter, Eric R.; Lavis, Luke D.; Chen, Zhixing; Mu, Yu; Li, Yulong
作者单位：Peking University; Peking University; Peking University; Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Peking University; Max Planck Society; NYU Langone Medical Center; New York University; Capital Medical University; Howard Hughes Medical Institute; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex networks has been hindered by the challenge of detecting multiple neurochemicals in vivo simultaneously. To overcome this limitation, we developed a single-protein chemigenetic DA sensor, HaloDA1.0, which combines a cpHaloTag-chemical dye approach with the G protein-coupled receptor activation-based (G...
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作者：Phelan, Meagan; Ranney, Megan
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作者：Zhang, Han; Wang, Han; Wright, Ian J.; Prentice, I. Colin; Harrison, Sandy P.; Smith, Nicholas G.; Westerband, Andrea C.; Rowland, Lucy; Plavcova, Lenka; Morris, Hugh; Reich, Peter B.; Jansen, Steven; Keenan, Trevor; Nguyen, Ngoc Bao
作者单位：Tsinghua University; Western Sydney University; Macquarie University; Western Sydney University; Imperial College London; University of Reading; Texas Tech University System; Texas Tech University; University of Louisiana Lafayette; University of Exeter; Czech University of Life Sciences Prague; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Minnesota System; University of Minnesota Twin Cities; Ulm University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：The efflux of carbon dioxide (CO2) from woody stems, a proxy for stem respiration, is a critical carbon flux from ecosystems to the atmosphere, which increases with temperature on short timescales. However, plants acclimate their respiratory response to temperature on longer timescales, potentially weakening the carbon-climate feedback. The magnitude of this acclimation is uncertain despite its importance for predicting future climate change. We develop an optimality-based theory dynamically l...
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作者：Farrell, Shane P.; Petras, Daniel; Stincone, Paolo; Yiu, Dara S.; Burns, John A.; Shah, Abzer Kelminal Pakkir; Hartmann, Aaron C.; Brady, Damian C.; Rasher, Douglas B.
作者单位：Bigelow Laboratory for Ocean Sciences; University of Maine System; University of Maine Orono; University of California System; University of California Riverside; Eberhard Karls University of Tubingen; Harvard University
摘要：In temperate regions experiencing rapid ocean warming, kelp forests are being replaced by chemically rich turf algae. However, the extent to which these turf algae alter the surrounding chemical environment or affect the rebound potential of kelp forests (through chemically mediated interactions) remains unknown. Here, we used underwater visual surveys, comprehensive chemical profiling, and laboratory experiments to reveal that turf algae release bioactive compounds into the water that fundame...
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作者：O'Grady, Cathleen
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作者：Cornwall, Warren
摘要：Politics and lawsuits imperil plans to divert the Mississippi River to build new land
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作者：Hou, Kaipeng; Huang, Wei; Qi, Miao; Tugwell, Thomas H.; Alturaifi, Turki M.; Chen, Yuda; Zhang, Xingjie; Lu, Lei; Mann, Samuel I.; Liu, Peng; Yang, Yang; DeGrado, William F.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Riverside; University of California System; University of California Santa Barbara
摘要：De novo design of protein catalysts with high efficiency and stereoselectivity provides an attractive approach toward the design of environmentally benign catalysts. Here, we design proteins that incorporate histidine-ligated synthetic porphyrin and heme ligands. Four of 10 designed proteins catalyzed cyclopropanation with an enantiomeric ratio greater than 99:1. A second class of proteins were designed to catalyze a silicon-hydrogen insertion and were optimized by directed evolution in whole ...
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作者：Malakoff, David
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作者：Zhu, Xin; Bennett, Timothy J. D.; Zouboulis, Konstantin C.; Soulias, Dimitrios; Grzybek, Michal; Benesch, Justin L. P.; El-Sagheer, Afaf H.; Coskun, Uenal; Krishnan, Madhavi
作者单位：University of Oxford; University of Oxford; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Southampton; University of Southampton; Technische Universitat Dresden; Carl Gustav Carus University Hospital; German Center for Diabetes Research (DZD); Max Planck Society
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作者：Funk, Michael
