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作者：Del Pace, Giulia; Hernandez-Rajkov, Diego; Singh, Vijay Pal; Grani, Nicola; Fernandez, Marcia Frometa; Nesti, Giulio; Seman, Jorge Amin; Inguscio, Massimo; Amico, Luigi; Roati, Giacomo
作者单位：University of Florence; University of Florence; Technology Innovation Institute; Universidad Nacional Autonoma de Mexico; University Campus Bio-Medico - Rome Italy; Istituto Nazionale di Fisica Nucleare (INFN); University of Catania
摘要：Driven many-body systems exhibit diverse and complex dynamical behaviors. Here, we report the observation of Shapiro steps in periodically driven Josephson junctions between strongly interacting Fermi superfluids of ultracold atoms. The height and the width of the observed quantized plateaus in the current-potential characteristics mirror the external drive frequency and the junction nonlinear response. Direct measurements of the current-phase relationship showcase how Shapiro steps arise from...
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作者：Ittner, A.
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作者：Leslie, Matthew S.; Roman, Joe; Sonne, Christian
作者单位：University of Vermont; Aarhus University
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作者：Zhou, Huabin; Huertas, Jan; Maristany, M. Julia; Russell, Kieran; Hwang, June Ho; Yao, Run-Wen; Samanta, Nirnay; Hutchings, Joshua; Billur, Ramya; Shiozaki, Momoko; Zhao, Xiaowei; Doolittle, Lynda K.; Gibson, Bryan A.; Soranno, Andrea; Riggi, Margot; Espinosa, Jorge R.; Yu, Zhiheng; Villa, Elizabeth; Collepardo-Guevara, Rosana; Rosen, Michael K.
作者单位：University of Texas System; Howard Hughes Medical Institute; University of Texas Southwestern Medical Center; Marine Biological Laboratory - Woods Hole; University of Cambridge; University of Cambridge; University of Cambridge; Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Diego; St Jude Children's Research Hospital; Howard Hughes Medical Institute; Max Planck Society; Howard Hughes Medical Institute; University of California System; University of California San Diego
摘要：The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo-electron tomography and molecular dynamics simulations, we elucidated the structure of phase-separated chromatin condensates across scales, from individual amino acids to network architecture. We found that internucleosomal DNA linker length controls nucleosome arrangement and histone tail interactions, shaping the structure of individual chromatin molecules within and outside ...
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作者：Cushing, Victoria I.; McGeoch, Amy J. S.; Williams, Sophie L.; Roumeliotis, Theodoros I.; Feng, Junjie; Dan, Lucy M.; Choudhary, Jyoti S.; Davey, Norman E.; Greber, Basil J.
作者单位：University of London; Royal Marsden NHS Foundation Trust; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of London; Royal Marsden NHS Foundation Trust; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Imperial College London; Francis Crick Institute
摘要：Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation of CDKs on a conserved threonine residue within the regulatory T-loop. However, structural data illuminating the mechanism by which the CAK recognizes and activates CDKs have remained elusive. In this study, we determined high-resolution structures of the CAK in complex with CDK2 and CDK2-cyclin A2...
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作者：Thorp, H. Holden
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作者：Kumar, Justin P.
作者单位：Indiana University System; Indiana University Bloomington
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作者：Evans, James; Duede, Eamon
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作者：Maire, Amandine; Bikard, David
作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; CNRS - National Institute for Biology (INSB)
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作者：Normile, Dennis
