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作者：Zhang, Qinghao; Dang, Weiwei; Wang, Meng C.
作者单位：Baylor College of Medicine; Howard Hughes Medical Institute
摘要：The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in Caenorhabditis elegans. Activation of lysosomal lipid signaling and lysosomal adenosine monophosphate-activated protein kinase (AMPK) or reduction of lysosomal mechanistic target of rapamycin (mTOR) signaling increased the expres...
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作者：Atterholt, James; McGuire, Jeffrey J.; Barbour, Andrew J.; Stewart, Connie; Moschetti, Morgan P.
作者单位：United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; California State University System; California State Polytechnic University Pomona
摘要：Fault structure and rupture physics are deeply intertwined, and observations of this coupling are critical for understanding earthquake behavior. Rupture propagation is observable at fine scales using dense seismic networks. Fiber-optic sensing allows for long-term deployments of ultradense arrays that enable high-resolution measurements of infrequent, large earthquakes. We recorded the 2024 moment magnitude (Mw) 7 Mendocino Fault earthquake with a nearby fiber-optic array and imaged its behav...
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作者：Drake, John M.
作者单位：University System of Georgia; University of Georgia; University of Oxford
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作者：Vogel, Gretchen
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作者：Zik, Justin J.; Price, Morgan N.; Mayra, Keisha Hanifa Alma; Santoso, Audrey A.; Arkin, Adam P.; Deutschbauer, Adam M.; Sham, Lok-To
作者单位：National University of Singapore; National University of Singapore; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform for assaying the fitness of a comprehensive double mutant pool in parallel. Dual Tn-seq couples random barcode transposon site sequencing with the Cre-lox system, enabling deep sampling of 73% of the 1.3 million possible double gene deletions in Streptococcus pneumoniae. The genetic interactions ...
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作者：Donnelly, Jane M.; Neff, Ryan A.; Sedlack, Andrew J. H.; Juska, Vuslat B.; Ayala-Cardona, Luis Fernando; Bass, Joseph; Mcnally, Elizabeth M.; Shah, Sanjiv J.; Alshurafa, Nabil; Kimchi, Eyal Y.; Budinger, G. R. Scott; Kelley, Shana O.
作者单位：Northwestern University; Northwestern University; Chan Zuckerberg Initiative (CZI); University College Cork; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University
摘要：Continuous biomarker monitoring is revolutionizing chronic disease management, with glucose monitoring for diabetes as the primary example. Given the success of this approach, a transition to continuous protein monitoring (CPM, a real-time, implantable or wearable technology) could similarly advance precision medicine. In this work, we review state-of-the-art CPM platforms and their prospective clinical impact across both chronic disorders-metabolic, cardiovascular, autoimmune, and neurodegene...
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作者：Mervis, Jeffrey
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作者：Zhang, Chen; Zhou, Jun; Xie, Pei-Pei; Rivera, Silvia M.; Alturaifi, Turki M.; Finnigan, James; Charnock, Simon; Liu, Peng; Yang, Yang
作者单位：University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Santa Barbara
摘要：Enzymatic multicomponent carbon-carbon (C-C) bond-forming reactions for diversity-oriented synthesis remain rare. Using cooperative photobiocatalysis, we developed a stereoselective three-component radical-mediated C-C coupling previously unknown in both organic chemistry and biochemistry. Directed evolution of repurposed pyridoxal decarboxylases enabled full fragment variability in this three-component coupling, giving rise to six classes of valuable products, many of which were inaccessible ...
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作者：Panchal, Aanchal; Sen, Ruchira; Agarwal, Renuka; Rana, Anjali; Raychoudhury, Rhitoban
作者单位：Indian Institute of Science Education & Research (IISER) - Mohali; Ashoka University
摘要：The symbiotic agriculture of fungus-farming termites can collapse if they fail to prevent invading weeds. Previous studies suggest a role for symbiotic fungistatic microbes in bringing about weed control. However, how termites employ these microbes to suppress fungal weeds without affecting the fungal cultivar remains unknown. We show that the fungus-farming termite Odontotermes obesus uses specific behaviors to remove, isolate, and suppress the growth of the fungal weed Pseudoxylaria, primari...
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作者：Medina, Iliana; Exnerova, Alice; Dankova, Klara; Penacchio, Olivier; Sherratt, Tom N.; Albrecht, Tomas; Baidya, Sarika; Bosque, Renan Janke; Brown, Heloise; Burdfield-Steel, Emily; Cain, Kristal E.; Cezario, Rodrigo Roucourt; Chiari, Ylenia; Esquivel, Carolina; Ferreira, Rhainer Guillermo; Franklin, Amanda M.; Garvey, Aloise; Guchu, Samuel; Hastings, Brandon T.; Hotova-Svadova, Katerina; Hwang, Yerin; Kang, Changku; Kasaya, John; Kelley, Jennifer; Kim, Yongsu; Kunte, Krushnamegh; Daetto-Liberato, Felipe; Loeffler-Henry, Karl; Lopez, Vinicius Marques; MacKay-Dietrich, Claire; Mappes, Johanna; De Marsico, Maria Cecilia; Nawge, Viraj; Njoroge, Peter; Nokelainen, Ossi; Pal, Arka; Paul, Archan; Posont, Robert; Raska, Jan; Reboreda, Juan Carlos; Rojas Ripari, Juan Manuel; Rowland, Hannah M.; Sabio, Maria de las Nieves; Salazar, Camilo; Salgado-Roa, Fabian C.; Stephens-Cardenas, Steve A.; Szabo, Anita; Mongui Torres, Juan Pablo; Troscianko, Jolyon; Truhlarova, Marie; Umbers, Kate D. L.; Venton, Molly; Vitasovich, Makenzie; Wang, Lu-Yi; Weil, Sarah-Sophie; Allen, William L.
作者单位：University of Melbourne; Charles University Prague; University of St Andrews; Centre de Visio per Computador (CVC); Autonomous University of Barcelona; Carleton University; Czech Academy of Sciences; Institute of Vertebrate Biology of the Czech Academy of Sciences; Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Swansea University; University of Amsterdam; University of Auckland; Universidade de Sao Paulo; George Mason University; University of Nottingham; Universidad Nacional Costa Rica; Universidade Federal do Triangulo Mineiro; Mokpo National University; Seoul National University (SNU); Seoul National University (SNU); University of Western Australia; University of Helsinki; University of Buenos Aires; University of Jyvaskyla; Czech University of Life Sciences Prague; Max Planck Society; Universidad del Rosario; Universidad Costa Rica; University of Exeter; Western Sydney University
摘要：Natural selection has repeatedly led to the evolution of two alternative antipredator color strategies-camouflage to avoid detection and aposematism to advertise unprofitability-but we lack understanding of how ecological context favors one strategy over the other. We conducted a globally replicated predation experiment at 21 sites on six continents to test how predator community, prey community, and visual environment influenced the predation risk of 15,018 artificial paper moth prey with cry...
