2025

最新文章

• Microcanonical kinetics of water-mediated proton transfer in microhydrated 4-aminobenzoic acid AI翻译
  作者：Rana, Abhijit; Harville, Payten A.; Khuu, Thien; Johnson, Mark A.
  作者单位：Yale University
  摘要：Isolated cluster systems can help to elucidate the molecular level description of water-mediated proton transfer. Protonation of neutral 4-aminobenzoic acid (4ABA) occurs at the acid (O-protomer) and amine (N-protomer) functionalities, yielding two distinct species with relative energies dependent on the degree of hydration. Here, we measured the rates of intramolecular proton transfer in 4ABAH+(H2O)6 ions upon protomer-selective vibrational excitation of initially cold (6 K) cluster ions isol...
• INSIDE AN ACADEMIC SCANDAL AI翻译
  作者：Fanelli, Daniele
  作者单位：Heriot Watt University
• My lucky detour AI翻译
  作者：Henson, Henry C.
  作者单位：Aarhus University
• Genomic signatures indicate biodiversity loss in an endemic island ant fauna AI翻译
  作者：Liu, Cong; Sarnat, Eli; Tan, Jo Ann; Janicki, Julia; Deyrup, John; Ogasawara, Masako; Grau, Miquel L.; Qiu, Lijun; Hita Garcia, Francisco; Fischer, Georg; Caginitoba, Akanisi; Narula, Nitish; Darwell, Clive T.; Kubota, Yasuhiro; Pierce, Naomi E.; Mikheyev, Alexander S.; Economo, Evan P.
  作者单位：Okinawa Institute of Science & Technology Graduate University; University of the Ryukyus; Harvard University; Okinawa Institute of Science & Technology Graduate University; Leibniz Institut fur Evolutions und Biodiversitatsforschung; Australian National University; University System of Maryland; University of Maryland College Park
  摘要：Insect populations have declined worldwide, but the extent and drivers of these declines are debated. Most studies rely on field surveys performed in the past century, leaving gaps in our understanding of longer-term trends. Using a community genomics approach, we estimated community assembly over millions of years and more recent demographic trends of ant species in the Fijian archipelago. We found that 79% of endemic species are in decline, starting after the arrival of humans approximately ...
• Science Under Siege AI翻译
  作者：Ranney, Megan L.
  作者单位：Yale University
• E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism AI翻译
  作者：Parisutham, Vinuselvi; Guharajan, Sunil; Lian, Melina; Ali, Md Zulfikar; Rogers, Hannah; Joyce, Shannon; Noto Guillen, Mariana; Brewster, Robert C.
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of Southern California
  摘要：Transcription factors (TFs) may activate or repress gene expression through an interplay of different mechanisms, including RNA polymerase (RNAP) recruitment, exclusion, and initiation. However, depending on the regulated promoter identity, TF function can vary, and the principles underlying this context dependence remain unclear. We demonstrate an inverse scaling relationship between the promoter's basal activity and its regulation by a given TF. Specifically, activation is weaker and repress...
• Cries into ties AI翻译
  作者：Bellone, Camilla
  作者单位：University of Geneva
• Structural basis for LZTR1 recognition of RAS GTPases for degradation AI翻译
  作者：Dharmaiah, Srisathiyanarayanan; Bonsor, Daniel A.; Mo, Stephanie P.; Fernandez-Cabrera, Alvaro; Chan, Albert H.; Messing, Simon; Drew, Matthew; Vega, Martha; Nissley, Dwight V.; Esposito, Dominic; Castel, Pau; Simanshu, Dhirendra K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：The RAS family of small guanosine triphosphatases (GTPases) are tightly regulated signaling molecules that are further modulated by ubiquitination and proteolysis. Leucine Zipper-like Transcription Regulator 1 (LZTR1), a substrate adapter of the Cullin-3 RING E3 ubiquitin ligase, binds specific RAS GTPases and promotes their ubiquitination and proteasomal degradation. We present structures of LZTR1 Kelch domains bound to RIT1, MRAS, and KRAS, revealing interfaces that govern RAS isoform select...
• Noncanonical circuits, states, and computations of the hippocampus AI翻译
  作者：Farrell, Jordan S.; Soltesz, Ivan
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Stanford University; Stanford University
  摘要：Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop-comprising the dentate gyrus and cornu ammonis regions CA3 and CA1-and back to cortex, where the hippocampus plays an important role in transforming relevant information into a usable storage system. This classic circuit has inspired current thinking on hippocampal functions related to learning, memory, and spatial navigation, but the potentia...
• The precarious future of consumer genetic privacy AI翻译
  作者：Ram, Natalie; Prince, Anya E. R.; Roberts, Jessica L.; Fox, Dov; Spector-Bagdady, Kayte
  作者单位：University System of Maryland; University of Maryland Baltimore; Johns Hopkins University; University of Iowa; Emory University; University of San Diego; University of Michigan System; University of Michigan