2025

最新文章

• Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus AI翻译
  作者：Meneu, Lea; Chapard, Christophe; Serizay, Jacques; Westbrook, Alex; Routhier, Etienne; Ruault, Myriam; Perrot, Manon; Minakakis, Alexandros; Girard, Fabien; Bignaud, Amaury; Even, Antoine; Gourgues, Geraldine; Libri, Domenico; Lartigue, Carole; Piazza, Aurele; Thierry, Agnes; Taddei, Angela; Beckouet, Frederic; Mozziconacci, Julien; Koszul, Romain
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Sorbonne Universite; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; INRAE; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN)
  摘要：In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated into Saccharomyces cerevisiae, which diverged from yeast more than 2 billion years ago, we show that nucleosomes, cohesins, and associated transcriptional machinery can lead to the formation of two di...
• Not just monkey business AI翻译
  作者：Moon, Robert W.; Bushell, Ellen S. C.
  作者单位：University of London; London School of Hygiene & Tropical Medicine; Umea University; Umea University
• Ends of the Earth: Journeys to the Polar Regions in Search of Life, the Cosmos, and Our Future AI翻译
  作者：Boon, Sarah
• The Silene latifolia genome and its giant Y chromosome AI翻译
  作者：Moraga, Carol; Branco, Catarina; Rougemont, Quentin; Jedlicka, Pavel; Mendoza-Galindo, Eddy; Veltsos, Paris; Hanique, Melissa; Rodriguez de la Vega, Ricardo C.; Tannier, Eric; Liu, Xiaodong; Lemaitre, Claire; Fields, Peter D.; Cruaud, Corinne; Labadie, Karine; Belser, Caroline; Briolay, Jerome; Santoni, Sylvain; Cegan, Radim; Linheiro, Raquel; Adam, Gabriele; El Filali, Adil; Mossion, Vinciane; Boualem, Adnane; Tavares, Raquel; Chebbi, Amine; Cordaux, Richard; Fruchard, Cecile; Prentout, Djivan; Velt, Amandine; Spataro, Bruno; Delmotte, Stephane; Weingartner, Laura; Toegelova, Helena; Tulpova, Zuzana; Capal, Petr; Simkova, Hana; Storchova, Helena; Krueger, Manuela; Abeyawardana, Oushadee A. J.; Taylor, Douglas R.; Olson, Matthew S.; Sloan, Daniel B.; Karrenberg, Sophie; Delph, Lynda F.; Charlesworth, Deborah; Muyle, Aline; Giraud, Tatiana; Bendahmane, Abdelhafid; Di Genova, Alex; Madoui, Mohammed-Amin; Hobza, Roman; Marais, Gabriel A. B.
  作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); VetAgro Sup; Universidad de O'Higgins; Universidad de O'Higgins; Universidade do Porto; Universidade do Porto; Universidade do Porto; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); AgroParisTech; Universite Paris Saclay; Czech Academy of Sciences; Institute of Biophysics of the Czech Academy of Sciences; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Vrije Universiteit Brussel; Universite Paris Cite; INRAE; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); Inria; Colorado State University System; Colorado State University Fort Collins; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; CIRAD; INRAE; Universite de Montpellier; Uppsala University; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paris Saclay; Columbia University; INRAE; University of Louisville; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; University of Virginia; Texas Tech University System; Texas Tech University; Uppsala University; Indiana University System; Indiana University Bloomington; University of Edinburgh; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Mathematical Sciences (INSMI); Universite Paris Saclay; CEA; Universidade do Porto
  摘要：In many species with sex chromosomes, the Y is a tiny chromosome. However, the dioecious plant Silene latifolia has a giant similar to 550-megabase Y chromosome, which has remained unsequenced so far. We used a long- and short-read hybrid approach to obtain a high-quality male genome. Comparative analysis of the sex chromosomes with their homologs in outgroups showed that the Y is highly rearranged and degenerated. Recombination suppression between X and Y extended in several steps and trigger...
• Does the mantis shrimp pack a phononic shield? AI翻译
  作者：Alderete, N. A.; Sandeep, S.; Raetz, S.; Asgari, M.; Abi Ghanem, M.; Espinosa, H. D.
  作者单位：Northwestern University; Le Mans Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS)
  摘要：The powerful strikes generated by the smasher mantis shrimp require it to possess a robust protection mechanism to withstand the resultant forces. Although recent studies have suggested that phononic bandgaps complement the mantis shrimp's defensive suite, direct experimental evidence for this mechanism has remained elusive. In this work, we explored the phononic properties of the mantis shrimp's dactyl club using laser ultrasonic techniques and numerical simulations. Our results demonstrate t...
• Randomizing the human genome by engineering recombination between repeat elements AI翻译
  作者：Koeppel, Jonas; Ferreira, Raphael; Vanderstichele, Thomas; Riedmayr, Lisa Maria; Peets, Elin Madli; Girling, Gareth; Weller, Juliane; Murat, Pierre; Liberante, Fabio Giuseppe; Ellis, Tom; Church, George McDonald; Parts, Leopold
  作者单位：Wellcome Trust Sanger Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Imperial College London; Harvard University; Harvard Medical School
  摘要：We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which enables generating large-scale deletions, inversions, translocations, and circular DNA. Recombinase induction produced more than 100 stochastic megabase-sized rearrangements in each cell. We tracked these rearrangements over time to measure selec...
• Learning the language of life with AI AI翻译
  作者：Topol, Eric J.
  作者单位：Scripps Research Institute
• Rising seas endanger maritime heritage AI翻译
  作者：Erlandson, Jon M.; Fitzpatrick, Scott M.; Gill, Kristina M.; Kirch, Patrick V.; Ruiz, John T.; Thompson, Victor D.; Younker, Jason
  作者单位：University of Oregon; University of Oregon; University of Hawaii System; University of Hawaii Manoa; University System of Georgia; University of Georgia
• Irregular mowing helps insects AI翻译
  作者：Brainard, Jeffrey
• Ancient genomics and the origin, dispersal, and development of domestic sheep AI翻译
  作者：Daly, Kevin G.; Mullin, Victoria E.; Hare, Andrew J.; Halpin, Aine; Mattiangeli, Valeria; Teasdale, Matthew D.; Rossi, Conor; Geiger, Sheila; Krebs, Stefan; Medugorac, Ivica; Sandoval-Castellanos, Edson; Ozbasaran, Mihriban; Duru, Gunes; Gulcur, Sevil; Poellath, Nadja; Collins, Matthew; Frantz, Laurent; Vila, Emmanuelle; Zidarov, Peter; Stoddart, Simon; Boldgiv, Bazartseren; Orlando, Ludovic; Pearson, Mike Parker; Mullville, Jacqui; Askeyev, Igor V.; Askeyev, Arthur O.; Askeyev, Oleg V.; Shaymuratova, Dilyara N.; Van den Hurk, Youri; Zeeb-Lanz, Andrea; Arbogast, Rose-Marie; Hemmer, Helmut; Davoudi, Hossein; Amiri, Sarieh; Doost, Sanaz Beizaee; Decruyenaere, Delphine; Fathi, Homa; Khazaeli, Roya; Hassanzadeh, Yousef; Sardari, Alireza; Lhuillier, Johanna; Abdolahi, Mostafa; Summers, Geoffrey D.; Marro, Catherine; Bahshaliyev, Veli; Berthon, Remi; Cakirlar, Canan; Benecke, Norbert; Scheu, Amelie; Burger, Joachim; Sauer, Eberhard; Horwitz, Liora Kolska; Arbuckle, Benjamin; Buitenhuis, Hijlke; Gourichon, Lionel; Bulatovic, Jelena; O'Connor, Terry; Orton, David; Jalabadze, Mindia; Rhodes, Stephen; Chazan, Michael; Ozkaya, Vecihi; Zeder, Melinda; Atici, Levent; Mashkour, Marjan; Peters, Joris; Bradley, Daniel G.
  作者单位：Trinity College Dublin; University College Dublin; Newcastle University - UK; University of Munich; University of Munich; University of Munich; University of Munich; Istanbul University; Mimar Sinan Guzel Sanatlar University; University of Copenhagen; University of Cambridge; University of London; Queen Mary University London; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Lyon 2; Eberhard Karls University of Tubingen; University of Cambridge; National University of Mongolia; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of London; University College London; Cardiff University; University of Groningen; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); University of Tehran; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Islamic Azad University; Nantes Universite; Azerbaijan National Academy of Sciences (ANAS); Johannes Gutenberg University of Mainz; University of Edinburgh; Hebrew University of Jerusalem; University of North Carolina; University of North Carolina Chapel Hill; Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); University of Gothenburg; University of York - UK; University of Toronto; University of Witwatersrand; Dicle University; Smithsonian Institution; North Carolina State University
  摘要：The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this, we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central Turkiye similar to 8000 BCE are genetically proximal to the domestic origins of sheep but do not fully explain the ancestry of later populations, suggesting a mosaic of wild ancestries. Genomic signatures indicate selection by ancient herders for pigmentation patterns, hornednes...