The Silene latifolia genome and its giant Y chromosome

• 成果类型: Article
• 署名作者: Moraga, Carol; Branco, Catarina; Rougemont, Quentin; Jedlicka, Pavel; Mendoza-Galindo, Eddy; Veltsos, Paris; Hanique, Melissa; Rodriguez de la Vega, Ricardo C.; Tannier, Eric; Liu, Xiaodong; Lemaitre, Claire; Fields, Peter D.; Cruaud, Corinne; Labadie, Karine; Belser, Caroline; Briolay, Jerome; Santoni, Sylvain; Cegan, Radim; Linheiro, Raquel; Adam, Gabriele; El Filali, Adil; Mossion, Vinciane; Boualem, Adnane; Tavares, Raquel; Chebbi, Amine; Cordaux, Richard; Fruchard, Cecile; Prentout, Djivan; Velt, Amandine; Spataro, Bruno; Delmotte, Stephane; Weingartner, Laura; Toegelova, Helena; Tulpova, Zuzana; Capal, Petr; Simkova, Hana; Storchova, Helena; Krueger, Manuela; Abeyawardana, Oushadee A. J.; Taylor, Douglas R.; Olson, Matthew S.; Sloan, Daniel B.; Karrenberg, Sophie; Delph, Lynda F.; Charlesworth, Deborah; Muyle, Aline; Giraud, Tatiana; Bendahmane, Abdelhafid; Di Genova, Alex; Madoui, Mohammed-Amin; Hobza, Roman; Marais, Gabriel A. B.
• 署名单位: Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); VetAgro Sup; Universidad de O'Higgins; Universidad de O'Higgins; Universidade do Porto; Universidade do Porto; Universidade do Porto; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); AgroParisTech; Universite Paris Saclay; Czech Academy of Sciences; Institute of Biophysics of the Czech Academy of Sciences; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Vrije Universiteit Brussel; Universite Paris Cite; INRAE; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); Inria; Colorado State University System; Colorado State University Fort Collins; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; CIRAD; INRAE; Universite de Montpellier; Uppsala University; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paris Saclay; Columbia University; INRAE; University of Louisville; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; University of Virginia; Texas Tech University System; Texas Tech University; Uppsala University; Indiana University System; Indiana University Bloomington; University of Edinburgh; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Mathematical Sciences (INSMI); Universite Paris Saclay; CEA; Universidade do Porto
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13793
• DOI: 10.1126/science.adj7430
• 发表日期: 2025-02-07
• 页码: 630-636
• 关键词: sex-chromosomes; evolutionary history; dosage compensation; white campion; MODEL; degeneration; dimorphism; reveals; gene

摘要

In many species with sex chromosomes, the Y is a tiny chromosome. However, the dioecious plant Silene latifolia has a giant similar to 550-megabase Y chromosome, which has remained unsequenced so far. We used a long- and short-read hybrid approach to obtain a high-quality male genome. Comparative analysis of the sex chromosomes with their homologs in outgroups showed that the Y is highly rearranged and degenerated. Recombination suppression between X and Y extended in several steps and triggered a massive accumulation of repeats on the Y as well as in the nonrecombining pericentromeric region of the X, leading to giant sex chromosomes. Using sex phenotype mutants, we identified candidate sex-determining genes on the Y in locations consistent with their favoring recombination suppression events 11 and 5 million years ago.