8013期

最新文章

• Why role-playing games can spur climate action AI翻译
  作者：Illingworth, Sam
  作者单位：Edinburgh Napier University
  摘要：Solving problems in a safe, collaborative environment can help us think out of the box and build empathy - crucial skills in a warming world.
• Promethium bound: fundamental chemistry of an elusive element finally observed AI翻译
  作者：Kvashnina, Kristina O.
  作者单位：Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
  摘要：The chemistry of promethium, a rare radioactive element, has been clouded in mystery, owing to its scarcity and the difficulties involved in working with it. The synthesis of a complex of promethium plugs this knowledge gap.
• FIRE POSES GROWING THREAT TO AFRICA'S TROPICAL FORESTS AI翻译
  作者：[Anonymous]
• Observation of a promethium complex in solution AI翻译
  作者：Driscoll, Darren M.; White, Frankie D.; Pramanik, Subhamay; Einkauf, Jeffrey D.; Ravel, Bruce; Bykov, Dmytro; Roy, Santanu; Mayes, Richard T.; Delmau, Laetitia H.; Cary, Samantha K.; Dyke, Thomas; Miller, April; Silveira, Matt; Vancleve, Shelley M.; Davern, Sandra M.; Jansone-Popova, Santa; Popovs, Ilja; Ivanov, Alexander S.
  作者单位：United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Oak Ridge National Laboratory
  摘要：Lanthanide rare-earth metals are ubiquitous in modern technologies 1-5 , but we know little about chemistry of the 61st element, promethium (Pm) 6 , a lanthanide that is highly radioactive and inaccessible. Despite its importance 7,8 , Pm has been conspicuously absent from the experimental studies of lanthanides, impeding our full comprehension of the so-called lanthanide contraction phenomenon: a fundamental aspect of the periodic table that is quoted in general chemistry textbooks. Here we d...
• Why the European Space Agency should join the US mission to Uranus AI翻译
  作者：Mousis, Olivier; Canup, Robin M.
  作者单位：Aix-Marseille Universite; Aix-Marseille Universite; Southwest Research Institute
  摘要：Without international partnerships, NASA's groundbreaking mission could fail to be ready in time for its optimal launch window.
• The phenomenon of genomic imprinting was discovered 40 years ago AI翻译
  作者：Ferguson-Smith, Anne C.; Bartolomei, Marisa S.
  作者单位：University of Cambridge; University of Pennsylvania
  摘要：Some genes carry an 'imprint' on either the maternal or the paternal copy, which determines whether or not that copy is expressed. This 1984 discovery changed how scientists think about gene regulation and inheritance.
• Resilience lessons from ancient societies are still relevant today AI翻译
  作者：Haldon, John
  作者单位：Princeton University
  摘要：What lessons can we learn from the factors that govern the resilience of human populations? A large-scale analysis examining ancient societies around the world provides a detailed look at what drives sustainability.
• Airway hillocks are injury-resistant reservoirs of unique plastic stem cells AI翻译
  作者：Lin, Brian; Shah, Viral S.; Chernoff, Chaim; Sun, Jiawei; Shipkovenska, Gergana G.; Vinarsky, Vladimir; Waghray, Avinash; Xu, Jiajie; Leduc, Andrew D.; Hintschich, Constantin A.; Surve, Manalee Vishnu; Xu, Yanxin; Capen, Diane E.; Villoria, Jorge; Dou, Zhixun; Hariri, Lida P.; Rajagopal, Jayaraj
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Tufts University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Northeastern University; University of Regensburg; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Airway hillocks are stratified epithelial structures of unknown function1. Hillocks persist for months and have a unique population of basal stem cells that express genes associated with barrier function and cell adhesion. Hillock basal stem cells continually replenish overlying squamous barrier cells. They exhibit dramatically higher turnover than the abundant, largely quiescent classic pseudostratified airway epithelium. Hillocks resist a remarkably broad spectrum of injuries, including toxi...
• Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer AI翻译
  作者：Wasko, Urszula N.; Jiang, Jingjing; Dalton, Tanner C.; Curiel-Garcia, Alvaro; Edwards, A. Cole; Wang, Yingyun; Lee, Bianca; Orlen, Margo; Tian, Sha; Stalnecker, Clint A.; Drizyte-Miller, Kristina; Menard, Marie; Dilly, Julien; Sastra, Stephen A.; Palermo, Carmine F.; Hasselluhn, Marie C.; Decker-Farrell, Amanda R.; Chang, Stephanie; Jiang, Lingyan; Wei, Xing; Yang, Yu C.; Helland, Ciara; Courtney, Haley; Gindin, Yevgeniy; Muonio, Karl; Zhao, Ruiping; Kemp, Samantha B.; Clendenin, Cynthia; Sor, Rina; Vostrejs, William P.; Hibshman, Priya S.; Amparo, Amber M.; Hennessey, Connor; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Brodbeck, Jens; Tomassoni, Lorenzo; Bakir, Basil; Socci, Nicholas D.; Herring, Laura E.; Barker, Natalie K.; Wang, Junning; Cleary, James M.; Wolpin, Brian M.; Chabot, John A.; Kluger, Michael D.; Manji, Gulam A.; Tsai, Kenneth Y.; Sekulic, Miroslav; Lagana, Stephen M.; Califano, Andrea; Quintana, Elsa; Wang, Zhengping; Smith, Jacqueline A. M.; Holderfield, Matthew; Wildes, David; Lowe, Scott W.; Badgley, Michael A.; Aguirre, Andrew J.; Vonderheide, Robert H.; Stanger, Ben Z.; Baslan, Timour; Der, Channing J.; Singh, Mallika; Olive, Kenneth P.
  作者单位：NewYork-Presbyterian Hospital; Columbia University; Columbia University; NewYork-Presbyterian Hospital; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Memorial Sloan Kettering Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of Pennsylvania; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Columbia University; NewYork-Presbyterian Hospital; Memorial Sloan Kettering Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; NewYork-Presbyterian Hospital; Columbia University; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; NewYork-Presbyterian Hospital; Columbia University; Johns Hopkins University; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Columbia University; NewYork-Presbyterian Hospital; Chan Zuckerberg Initiative (CZI); Howard Hughes Medical Institute; Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Pennsylvania
  摘要：Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations 1,2 . RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS and NRAS, with affinity for both mutant and wild-type variants 3 . More than 90% of cases of human pancreatic ductal adenocarcinoma (PDAC) are driven by activating mutations in KRAS 4 . Here we assessed the therapeutic potential of RMC-7977 in a comprehensiv...
• Stepwise activation of a metabotropic glutamate receptor AI翻译
  作者：Kumar, Kaavya Krishna; Wang, Haoqing; Habrian, Chris; Latorraca, Naomi R.; Xu, Jun; O'Brien, Evan S.; Zhang, Chensong; Montabana, Elizabeth; Koehl, Antoine; Marqusee, Susan; Isacoff, Ehud Y.; Kobilka, Brian K.
  作者单位：Stanford University; Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding domain that is linked via a cysteine-rich domain to their 7-transmembrane domain(1). Upon activation, these receptors undergo a large conformational change to transmit the ligand binding signal from the extracellular ligand-binding domain to the G protein-coupling 7-transmembrane domain(2). In this manuscript, we propose a model for a sequ...