8013期

最新文章

• Complete biosynthesis of QS-21 in engineered yeast AI翻译
  作者：Liu, Yuzhong; Zhao, Xixi; Gan, Fei; Chen, Xiaoyue; Deng, Kai; Crowe, Samantha A.; Hudson, Graham A.; Belcher, Michael S.; Schmidt, Matthias; Astolfi, Maria C. T.; Kosina, Suzanne M.; Pang, Bo; Shao, Minglong; Yin, Jing; Sirirungruang, Sasilada; Iavarone, Anthony T.; Reed, James; Martin, Laetitia B. B.; El-Demerdash, Amr; Kikuchi, Shingo; Misra, Rajesh Chandra; Liang, Xiaomeng; Cronce, Michael J.; Chen, Xiulai; Zhan, Chunjun; Kakumanu, Ramu; Baidoo, Edward E. K.; Chen, Yan; Petzold, Christopher J.; Northen, Trent R.; Osbourn, Anne; Scheller, Henrik; Keasling, Jay D.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Joint BioEnergy Institute - JBEI; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Suranaree University of Technology; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Egyptian Knowledge Bank (EKB); Mansoura University; Technical University of Denmark
  摘要：QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans(1,2). However, owing to the complex structure of QS-21, its availability is limited. Today, the supply depends on laborious extraction from the Chilean soapbark tree or on low-yielding total chemical synthesis(3,4). Here we demonstrate the complete biosynthesis of QS-21 and its precursors, as well as structural derivatives, in engineered yeast strains. The successf...
• Computationally restoring the potency of a clinical antibody against Omicron AI翻译
  作者：Desautels, Thomas A.; Arrildt, Kathryn T.; Zemla, Adam T.; Lau, Edmond Y.; Zhu, Fangqiang; Ricci, Dante; Cronin, Stephanie; Zost, Seth J.; Binshtein, Elad; Scheaffer, Suzanne M.; Dadonaite, Bernadeta; Petersen, Brenden K.; Engdahl, Taylor B.; Chen, Elaine; Handal, Laura S.; Hall, Lynn; Goforth, John W.; Vashchenko, Denis; Nguyen, Sam; Weilhammer, Dina R.; Lo, Jacky Kai-Yin; Rubinfeld, Bonnee; Saada, Edwin A.; Weisenberger, Tracy; Lee, Tek-Hyung; Whitener, Bradley; Case, James B.; Ladd, Alexander; Silva, Mary S.; Haluska, Rebecca M.; Grzesiak, Emilia A.; Earnhart, Christopher G.; Hopkins, Svetlana; Bates, Thomas W.; Thackray, Larissa B.; Segelke, Brent W.; Lillo, Antonietta Maria; Sundaram, Shivshankar; Bloom, Jesse D.; Diamond, Michael S.; Crowe, James E., Jr.; Carnahan, Robert H.; Faissol, Daniel M.; Lyon, Emily Z. Alipio; Anderson, Penelope S.; Avila-Herrera, Aram; Bennett, William F.; Bourguet, Feliza A.; Chen, Julian C.; Coleman, Matthew A.; Collette, Nicole M.; Davis, Anastasiia; Vannest, Byron D.; Fong, Erika J.; Gilmore, Sean; Goncalves, Andre R.; Hall, Sara B.; Harmon, Brooke; He, Wei; Hoang-Phou, Steven A.; Landajuela, Mikel; Laurence, Ted A.; Lee, Tek Hyung; Da Silva, Felipe Leno; Liu, Chao; Mundhenk, Terrel N.; Mohagheghi, Mariam V.; McIlroy, Peter R.; Le Thanh Mai Pham; Sanchez, Joseph C.; Sinha, Anupama; Solomon, Emilia A.; Watkins, Nicholas; Yang, Jiachen; Ye, Congwang; Zhang, Boya
  作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Vanderbilt University; Washington University (WUSTL); Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Defense; United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Howard Hughes Medical Institute; Washington University (WUSTL); Washington University (WUSTL); Vanderbilt University; Alphabet Inc.; Google Incorporated; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories
  摘要：The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs(1-3) and revealed how quickly viral escape can curtail effective options(4,5). When the SARS-CoV-2 Omicron variant emerged in 2021, many antibody drug products lost potency, including Evusheld and its constituent, cilgavimab(4-6). Cilgavimab, like its progenitor COV2-2130, is a class 3 antibody that is compatible with other antibodies in combination(4) and is challenging to replace wit...
• High carrier mobility along the [111] orientation in Cu2O photoelectrodes (vol 628, pg 765, 2024) AI翻译
  作者：Pan, Linfeng; Dai, Linjie; Burton, Oliver J.; Chen, Lu; Andrei, Virgil; Zhang, Youcheng; Ren, Dan; Cheng, Jinshui; Wu, Linxiao; Frohna, Kyle; Abfalterer, Anna; Yang, Terry Chien-Jen; Niu, Wenzhe; Xia, Meng; Hofmann, Stephan; Dyson, Paul J.; Reisner, Erwin; Sirringhaus, Henning; Luo, Jingshan; Hagfeldt, Anders; Graetzel, Michael; Stranks, Samuel D.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Nankai University; Uppsala University
• Global sites for mutations of unknown origins AI翻译
  作者：Franco, Irene; Supek, Fran
  作者单位：Vita-Salute San Raffaele University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Copenhagen; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona
  摘要：Genetic sequencing of human kidney cancers worldwide has revealed associations between geographical locations and specific mutation patterns, indicating exposure to known and unknown mutation-promoting agents.
• Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase (Expression of Concern of Vol 415, Pg 339, 2002) AI翻译
  作者：Minokoshi, Yasuhiko; Kim, Young-Bum; Peroni, Odile D.; Fryer, Lee G. D.; Mueller, Corinna; Carling, David; Kahn, Barbara B.
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard Medical School; Imperial College London
• Internet use and teen mental health: its about more than just screen time AI翻译
  作者：Zhang, Linxiao
  作者单位：University of Toronto
  摘要：Letter to the Editor
• Full-colour 3D holographic augmented-reality displays with metasurface waveguides AI翻译
  作者：Gopakumar, Manu; Lee, Gun-Yeal; Choi, Suyeon; Chao, Brian; Peng, Yifan; Kim, Jonghyun; Wetzstein, Gordon
  作者单位：Stanford University; University of Hong Kong; Nvidia Corporation
  摘要：Emerging spatial computing systems seamlessly superimpose digital information on the physical environment observed by a user, enabling transformative experiences across various domains, such as entertainment, education, communication and training(1-3). However, the widespread adoption of augmented-reality (AR) displays has been limited due to the bulky projection optics of their light engines and their inability to accurately portray three-dimensional (3D) depth cues for virtual content, among...
• HARASSMENT OF SCIENTISTS IS SURGING. HOW SHOULD INSTITUTIONS RESPOND? AI翻译
  作者：Nogrady, Bianca
  摘要：As researchers increasingly face many kinds of attack over their work, there is debate about how to support and protect them.
• Measurement of the superfluid fraction of a supersolid by Josephson effect AI翻译
  作者：Biagioni, G.; Antolini, N.; Donelli, B.; Pezze, L.; Smerzi, A.; Fattori, M.; Fioretti, A.; Gabbanini, C.; Inguscio, M.; Tanzi, L.; Modugno, G.
  作者单位：University of Florence; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); University of Florence; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); Istituto Nazionale Astrofisica (INAF); University of Naples Federico II; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); University Campus Bio-Medico - Rome Italy
  摘要：A new class of superfluids and superconductors with spatially periodic modulation of the superfluid density is arising(1-12). It might be related to the supersolid phase of matter, in which the spontaneous breaking of gauge and translational symmetries leads to a spatially modulated macroscopic wavefunction(13-16). This relation was recognized only in some cases(1,2,5-9) and there is the need for a universal property quantifying the differences between supersolids and ordinary matter, such as ...
• The High Seas: Ambition, Power and Greed on the Unclaimed Ocean AI翻译
  作者：Amon, Diva; Palacios Abrantes, Juliano