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作者：Mullard, Asher
摘要：Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
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作者：Kumar, Kaavya Krishna; Wang, Haoqing; Habrian, Chris; Latorraca, Naomi R.; Xu, Jun; O'Brien, Evan S.; Zhang, Chensong; Montabana, Elizabeth; Koehl, Antoine; Marqusee, Susan; Isacoff, Ehud Y.; Kobilka, Brian K.
作者单位：Stanford University; Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
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作者：Senkin, Sergey; Moody, Sarah; Diaz-Gay, Marcos; Abedi-Ardekani, Behnoush; Cattiaux, Thomas; Ferreiro-Iglesias, Aida; Wang, Jingwei; Fitzgerald, Stephen; Kazachkova, Mariya; Vangara, Raviteja; Anh Phuong Le; Bergstrom, Erik N.; Khandekar, Azhar; Otlu, Burcak; Cheema, Saamin; Latimer, Calli; Thomas, Emily; Atkins, Joshua Ronald; Smith-Byrne, Karl; Cardoso Penha, Ricardo Cortez; Carreira, Christine; Chopard, Priscilia; Gaborieau, Valerie; Keski-Rahkonen, Pekka; Jones, David; Teague, Jon W.; Ferlicot, Sophie; Asgari, Mojgan; Sangkhathat, Surasak; Attawettayanon, Worapat; Swiatkowska, Beata; Jarmalaite, Sonata; Sabaliauskaite, Rasa; Shibata, Tatsuhiro; Fukagawa, Akihiko; Mates, Dana; Jinga, Viorel; Rascu, Stefan; Mijuskovic, Mirjana; Savic, Slavisa; Milosavljevic, Sasa; Bartlett, John M. S.; Albert, Monique; Phouthavongsy, Larry; Ashton-Prolla, Patricia; Botton, Mariana R.; Neto, Brasil Silva; Bezerra, Stephania Martins; Curado, Maria Paula; Zequi, Stenio de Cassio; Reis, Rui Manuel; Faria, Eliney Ferreira; de Menezes, Nei Soares; Ferrari, Renata Spagnoli; Banks, Rosamonde E.; Vasudev, Naveen S.; Zaridze, David; Mukeriya, Anush; Shangina, Oxana; Matveev, Vsevolod; Foretova, Lenka; Navratilova, Marie; Holcatova, Ivana; Hornakova, Anna; Janout, Vladimir; Purdue, Mark P.; Rothman, Nathaniel; Chanock, Stephen J.; Ueland, Per Magne; Johansson, Mattias; McKay, James; Scelo, Ghislaine; Chanudet, Estelle; Humphreys, Laura; de Carvalho, Ana Carolina; Perdomo, Sandra; Alexandrov, Ludmil B.; Stratton, Michael R.; Brennan, Paul
作者单位：World Health Organization; International Agency for Research on Cancer (IARC); Wellcome Trust Sanger Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Middle East Technical University; University of Oxford; World Health Organization; International Agency for Research on Cancer (IARC); World Health Organization; International Agency for Research on Cancer (IARC); Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Iran University of Medical Sciences; Iran University of Medical Sciences; Prince of Songkla University; Prince of Songkla University; Nofer Institute of Occupational Medicine; National Cancer Institute - Lithuania; Vilnius University; University of Tokyo; National Cancer Center - Japan; University of Tokyo; Carol Davila University of Medicine & Pharmacy; University of Belgrade; University of Edinburgh; University of Guelph; University of Toronto; Ontario Institute for Cancer Research; Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto Alegre; Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande do Sul; A.C.Camargo Cancer Center; A.C.Camargo Cancer Center; A.C.Camargo Cancer Center; A.C.Camargo Cancer Center; Universidade Federal de Sao Paulo (UNIFESP); Hospital de Cancer de Barretos; Universidade do Minho; Hospital de Cancer de Barretos; Hospital de Cancer de Barretos; University of Leeds; Masaryk Memorial Cancer Institute; Charles University Prague; Motol University Hospital; Charles University Prague; Motol University Hospital; Motol University Hospital; Charles University Prague; Palacky University Olomouc; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics; Radboud University Nijmegen
摘要：International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden(1). In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence(2). Underlying causes can be inferred by sequencing the genomes of cancers from populations with different ...
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作者：Miyamoto, Yu; Kikuta, Junichi; Matsui, Takahiro; Hasegawa, Tetsuo; Fujii, Kentaro; Okuzaki, Daisuke; Liu, Yu-chen; Yoshioka, Takuya; Seno, Shigeto; Motooka, Daisuke; Uchida, Yutaka; Yamashita, Erika; Kobayashi, Shogo; Eguchi, Hidetoshi; Morii, Eiichi; Tryggvason, Karl; Shichita, Takashi; Kayama, Hisako; Atarashi, Koji; Kunisawa, Jun; Honda, Kenya; Takeda, Kiyoshi; Ishii, Masaru
作者单位：University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka; National University of Singapore; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); University of Osaka; Keio University
摘要：The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal to central veins constitutes heterogenous zones, including the periportal vein (PV) and the pericentral vein zones(1-5). However, functional differences in the immune system in each zone remain poorly understood. Here intravital imaging revealed that inflammatory responses are suppressed in PV zones. Zone-specific single-cell transcriptomics detected a subset of immunosuppressive macrophages enriched...
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作者：Madhusoodanan, Jyoti
摘要：Mackenzie and Alexander Mathis were still early in their careers when their software created a sensation. Now they're using it to support other young scientists.
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作者：[Anonymous]
摘要：Millions of people died of COVID-19 because the fundamental principle of equity between nations was ignored during the outbreak. That must not be allowed to happen again.
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作者：Mahon, Michael B.; Sack, Alexandra; Aleuy, O. Alejandro; Barbera, Carly; Brown, Ethan; Buelow, Heather; Civitello, David J.; Cohen, Jeremy M.; de Wit, Luz A.; Forstchen, Meghan; Halliday, Fletcher W.; Heffernan, Patrick; Knutie, Sarah A.; Korotasz, Alexis; Larson, Joanna G.; Rumschlag, Samantha L.; Selland, Emily; Shepack, Alexander; Vincent, Nitin; Rohr, Jason R.
作者单位：University of Notre Dame; University of Notre Dame; University of Notre Dame; Emory University; Yale University; Oregon State University; University of Connecticut
摘要：Anthropogenic change is contributing to the rise in emerging infectious diseases, which are significantly correlated with socioeconomic, environmental and ecological factors(1). Studies have shown that infectious disease risk is modified by changes to biodiversity(2-6), climate change(7-11), chemical pollution(12-14), landscape transformations(15-20) and species introductions(21). However, it remains unclear which global change drivers most increase disease and under what contexts. Here we ama...
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作者：Cheema, Suraj S.; Shanker, Nirmaan; Hsu, Shang-Lin; Schaadt, Joseph; Ellis, Nathan M.; Cook, Matthew; Rastogi, Ravi; Pilawa-Podgurski, Robert C. N.; Ciston, Jim; Mohamed, Mohamed; Salahuddin, Sayeef
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Lincoln Laboratory; Massachusetts Institute of Technology (MIT); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Massachusetts Institute of Technology (MIT)
摘要：Dielectric electrostatic capacitors(1), because of their ultrafast charge-discharge, are desirable for high-power energy storage applications. Along with ultrafast operation, on-chip integration can enable miniaturized energy storage devices for emerging autonomous microelectronics and microsystems(2-5). Moreover, state-of-the-art miniaturized electrochemical energy storage systems-microsupercapacitors and microbatteries-currently face safety, packaging, materials and microfabrication challeng...
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作者：Zhang, Linxiao
作者单位：University of Toronto
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作者：Longwitz, Lars; Leveson-Gower, Reuben B.; Rozeboom, Henriette J.; Thunnissen, Andy-Mark W. H.; Roelfes, Gerard
作者单位：University of Groningen; University of Groningen
摘要：Enzymes play an increasingly important role in improving the benignity and efficiency of chemical production, yet the diversity of their applications lags heavily behind chemical catalysts as a result of the relatively narrow range of reaction mechanisms of enzymes. The creation of enzymes containing non-biological functionalities facilitates reaction mechanisms outside nature's canon and paves the way towards fully programmable biocatalysis1-3. Here we present a completely genetically encoded...
