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作者：Voloshina, Alexandra S.
作者单位：University of California System; University of California Irvine
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作者：Li, Ning; Yan, Kexin; Rukkijakan, Thanya; Liang, Jiefeng; Liu, Yuting; Wang, Zhipeng; Nie, Heran; Muangmeesri, Suthawan; Castiella-Ona, Gonzalo; Pan, Xuejun; Zhou, Qunfang; Jiang, Guibin; Zhou, Guangyuan; Ralph, John; Samec, Joseph S. M.; Wang, Feng
作者单位：Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Stockholm University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Shandong University; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Lignocellulose is mainly composed of hydrophobic lignin and hydrophilic polysaccharide polymers, contributing to an indispensable carbon resource for green biorefineries(1,2). When chemically treated, lignin is compromised owing to detrimental intra- and intermolecular crosslinking that hampers downstream process(3,4). The current valorization paradigms aim to avoid the formation of new C-C bonds, referred to as condensation, by blocking or stabilizing the vulnerable moieties of lignin(5-7). A...
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作者：Ledford, Heidi
摘要：Researchers in India fought to develop what could have been the first therapy to use gene-editing to halt a rare neurodegenerative disease. The efforts hold lessons for the messy state of modern drug development.
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作者：Aguade-Gorgorio, Julia; Jami-Alahmadi, Yasaman; Calvanese, Vincenzo; Kardouh, Maya; Fares, Iman; Johnson, Haley; Rezek, Valerie; Ma, Feiyang; Magnusson, Mattias; Wang, Yanling; Shin, Juliana E.; Nance, Karina J.; Goodridge, Helen S.; Liebscher, Simone; Schenke-Layland, Katja; Crooks, Gay M.; Wohlschlegel, James A.; Mikkola, Hanna K. A.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of London; University College London; Institut de Recerca Contra la Leucemia Josep Carreras (IJC); University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Lund University; Cedars Sinai Medical Center; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Pfizer; Pfizer USA; Oakland University; University of California System; University of California San Francisco; Amgen
摘要：The processes that govern human haematopoietic stem cell (HSC) self-renewal and engraftment are poorly understood and challenging to recapitulate in culture to reliably expand functional HSCs1-3. Here we identify MYC target1 (MYCT1; also known as MTLC) as a crucial human HSC regulator that moderates endocytosis and environmental sensing in HSCs. MYCT1 is selectively expressed in undifferentiated human haematopoietic stem and progenitor cells (HSPCs) and endothelial cells but becomes markedly d...
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作者：Alexander, Denis R.; White, Robert S.
作者单位：University of Cambridge
摘要：Letter to the Editor
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作者：Willemart, Rodrigo Hirata; Marques, Antonio Carlos
作者单位：Universidade de Sao Paulo
摘要：Letter to the Editor
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作者：Leenders, R. A.; Afanasiev, D.; Kimel, A. V.; Mikhaylovskiy, R. V.
作者单位：Lancaster University; Radboud University Nijmegen
摘要：Traditionally, magnetic solids are divided into two main classes-ferromagnets and antiferromagnets with parallel and antiparallel spin orders, respectively. Although normally the antiferromagnets have zero magnetization, in some of them an additional antisymmetric spin-spin interaction arises owing to a strong spin-orbit coupling and results in canting of the spins, thereby producing net magnetization. The canted antiferromagnets combine antiferromagnetic order with phenomena typical of ferrom...
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作者：Ding, S.; Garofalo, A. M.; Wang, H. Q.; Weisberg, D. B.; Li, Z. Y.; Jian, X.; Eldon, D.; Victor, B. S.; Marinoni, A.; Hu, Q. M.; Carvalho, I. S.; Odstrcil, T.; Wang, L.; Hyatt, A. W.; Osborne, T. H.; Gong, X. Z.; Qian, J. P.; Huang, J.; McClenaghan, J.; Holcomb, C. T.; Hanson, J. M.
作者单位：General Atomics & Affiliated Companies; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of California System; University of California San Diego; Massachusetts Institute of Technology (MIT); Princeton University; United States Department of Energy (DOE); Princeton Plasma Physics Laboratory; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Columbia University
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作者：Abramson, Josh; Adler, Jonas; Dunger, Jack; Evans, Richard; Green, Tim; Pritzel, Alexander; Ronneberger, Olaf; Willmore, Lindsay; Ballard, Andrew J.; Bambrick, Joshua; Bodenstein, Sebastian W.; Evans, David A.; Hung, Chia-Chun; O'Neill, Michael; Reiman, David; Tunyasuvunakool, Kathryn; Wu, Zachary; Zemgulyte, Akvile; Arvaniti, Eirini; Beattie, Charles; Bertolli, Ottavia; Bridgland, Alex; Cherepanov, Alexey; Congreve, Miles; Cowen-Rivers, Alexander I.; Cowie, Andrew; Figurnov, Michael; Fuchs, Fabian B.; Gladman, Hannah; Jain, Rishub; Khan, Yousuf A.; Low, Caroline M. R.; Perlin, Kuba; Potapenko, Anna; Savy, Pascal; Singh, Sukhdeep; Stecula, Adrian; Thillaisundaram, Ashok; Tong, Catherine; Yakneen, Sergei; Zhong, Ellen D.; Zielinski, Michal; Zidek, Augustin; Bapst, Victor; Kohli, Pushmeet; Jaderberg, Max; Hassabis, Demis; Jumper, John M.
作者单位：Alphabet Inc.; DeepMind; Google Incorporated; Alphabet Inc.; DeepMind; Google Incorporated; Stanford University; Princeton University
摘要：The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design 2-6 . Here we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues. The new AlphaFold model demonstrates substantially improved ...
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作者：Lenharo, Mariana
摘要：Delegates were at an impasse over key issues, but agreements on other public-health emergency measures spark cautious optimism.
