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作者：Zhang, Shouyue; Sun, Ao; Qian, Jing-Mei; Lin, Shuo; Xing, Wenjing; Yang, Yun; Zhu, Han-Zhou; Zhou, Xin-Yi; Guo, Yan-Shuo; Liu, Yun; Meng, Yu; Jin, Shu-Lin; Song, Wenhao; Li, Cheng-Ping; Li, Zhaofu; Jin, Shuai; Wang, Jian-Hua; Dong, Meng-Qiu; Gao, Caixia; Chen, Chunlai; Bai, Yang; Liu, Jun-Jie Gogo
作者单位：Tsinghua University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; National Institute of Biological Sciences, Beijing; Tsinghua University; Peking University
摘要：The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA(1). As part of the ongoing struggle between phages and the bacterial immune system, the CRISPR system has evolved into various types, each with distinct functionalities(2). Type II Cas9 is the most extensively studied of these systems and has diverse subtypes. It remains uncertain whether members of this family can evolve additional mechanisms to counter viral invasio...
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作者：Brown, Jane
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作者：Munoz, Kristen A.; Ulrich, Rebecca J.; Vasan, Archit K.; Sinclair, Matt; Wen, Po-Chao; Holmes, Jessica R.; Lee, Hyang Yeon; Hung, Chien-Che; Fields, Christopher J.; Tajkhorshid, Emad; Lau, Gee W.; Hergenrother, Paul J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Infections caused by Gram-negative pathogens are increasingly prevalent and are typically treated with broad-spectrum antibiotics, resulting in disruption of the gut microbiome and susceptibility to secondary infections(1-3). There is a critical need for antibiotics that are selective both for Gram-negative bacteria over Gram-positive bacteria, as well as for pathogenic bacteria over commensal bacteria. Here we report the design and discovery of lolamicin, a Gram-negative-specific antibiotic t...
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作者：Yamada-Hunter, Sean A.; Theruvath, Johanna; McIntosh, Brianna J.; Freitas, Katherine A.; Lin, Frank; Radosevich, Molly T.; Leruste, Amaury; Dhingra, Shaurya; Martinez-Velez, Naiara; Xu, Peng; Huang, Jing; Delaidelli, Alberto; Desai, Moksha H.; Good, Zinaida; Polak, Roel; May, Audre; Labanieh, Louai; Bjelajac, Jeremy; Murty, Tara; Ehlinger, Zach; Mount, Christopher W.; Chen, Yiyun; Heitzeneder, Sabine; Marjon, Kristopher D.; Banuelos, Allison; Khan, Omair; Wasserman, Savannah L.; Spiegel, Jay Y.; Fernandez-Pol, Sebastian; Kuo, Calvin J.; Sorensen, Poul H.; Monje, Michelle; Majzner, Robbie G.; Weissman, Irving L.; Sahaf, Bita; Sotillo, Elena; Cochran, Jennifer R.; Mackall, Crystal L.
作者单位：Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; British Columbia Cancer Agency; Stanford University; Stanford University; Princess Maxima Center; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; University of Miami; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Adoptively transferred T cells and agents designed to block the CD47-SIRP alpha axis are promising cancer therapeutics that activate distinct arms of the immune system(1,2). Here we administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing chimeric antigen receptors (CARs) or engineered T cell receptors. Anti-CD47-...
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作者：Kozlov, Max; Wolf, Lauren
摘要：Long-awaited testimony ends in fireworks as US lawmakers spar over the former infectious-disease official's pandemic actions.
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作者：Kulkarni, Sumeet
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作者：Luo, Shuzhen; Jiang, Menghan; Zhang, Sainan; Zhu, Junxi; Yu, Shuangyue; Silva, Israel Dominguez; Wang, Tian; Rouse, Elliott; Zhou, Bolei; Yuk, Hyunwoo; Zhou, Xianlian; Su, Hao
作者单位：North Carolina State University; Embry-Riddle Aeronautical University; University of Michigan System; University of Michigan; University of California System; University of California Los Angeles; Korea Advanced Institute of Science & Technology (KAIST); New Jersey Institute of Technology; North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Exoskeletons have enormous potential to improve human locomotive performance1-3. However, their development and broad dissemination are limited by the requirement for lengthy human tests and handcrafted control laws2. Here we show an experiment-free method to learn a versatile control policy in simulation. Our learning-in-simulation framework leverages dynamics-aware musculoskeletal and exoskeleton models and data-driven reinforcement learning to bridge the gap between simulation and reality w...
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作者：Yalcin, Belgin; Monje, Michelle
作者单位：Stanford University
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作者：Hannah, Lee; Irvine, Amy; Brito-Morales, Isaac; Fuller, Susanna; Davies, Tammy; Tittensor, Derek; Reville, Grace; Shackell, Nancy; Hennicke, Janos; Stanley, Ryan
作者单位：Conservation International; BirdLife International; Dalhousie University; Fisheries & Oceans Canada; Bedford Institute of Oceanography; Fisheries & Oceans Canada; Bedford Institute of Oceanography
摘要：Species are already on the move as waters warm. Conservation plans need to take this into account.
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作者：Leeming, Jack; Elman, Robyn
