作者：Najam, Adil
作者单位：Boston University
摘要：The International Court of Justice is set to clarify the responsibilities of states to act on global warming. Governments must step up in support - before it's too late.
作者：Ludwig, Alexander
作者单位：Nanyang Technological University; Nanyang Technological University
摘要：Cells that form tissue barriers rely on cell-cell contacts called tight junctions. These structures assemble from protein condensates that spread along the cell membrane like a water droplet spreading over glass. Step-by-step formation of tight junctions between epithelial cells.
作者：Park, Juhyung; Wu, Jibo; Szkop, Krzysztof J.; Jeong, Jinho; Jovanovic, Predrag; Husmann, Dylan; Flores, Natasha M.; Francis, Joel W.; Chen, Ying-Jiun C.; Benitez, Ana Morales; Zahn, Emily; Song, Shumei; Ajani, Jaffer A.; Wang, Linghua; Singh, Kamini; Larsson, Ola; Garcia, Benjamin A.; Topisirovic, Ivan; Gozani, Or; Mazur, Pawel K.
作者单位：Stanford University; University of Texas System; UTMD Anderson Cancer Center; Karolinska Institutet; Lady Davis Institute; McGill University; McGill University; Washington University (WUSTL); University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; University of Texas System; UTMD Anderson Cancer Center
摘要：Dysregulated transcription due to disruption in histone lysine methylation dynamics is an established contributor to tumorigenesis(1,2). However, whether analogous pathologic epigenetic mechanisms act directly on the ribosome to advance oncogenesis is unclear. Here we find that trimethylation of the core ribosomal protein L40 (rpL40) at lysine 22 (rpL40K22me3) by the lysine methyltransferase SMYD5 regulates mRNA translation output to promote malignant progression of gastric adenocarcinoma (GAC...
